Zheng Baijun,Cheng Jiwen,Gao Ya,et al.Safety,feasibility and short-term outcome of laparoscopic liver resection versus open liver resection for hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,18():935-940.[doi:10.3969/j.issn.1671—6353.2019.11.008]
Safety,feasibility and short-term outcome of laparoscopic liver resection versus open liver resection for hepatoblastoma
- Keywords:
- Liver Neoplasms; Laparoscopy; Laparotomy; Hepatectomy; Treatment Outcome
- CLC:
- R735.7;R726.1
- Abstract:
- Objective To explore the safety,feasibility and short-term outcome of laparoscopic versus open liver resection (LLR vs OLR) for hepatoblastoma (HB).Methods The perioperative and follow-up data of LLR (n=17) and OLR (n=26) for HB operations at the same period were analyzed respectively from January 2012 to May 2019.Results No significant inter-group differences existed in age,gender,hemoglobin concentration,liver function,alpha fetoprotein (AFP) level and size/number/location/PRETEXT stage of tumor (P>0.05).As compared with OLR group,estimated blood loss was less and mean operative time longer in LLR group (P<0.01).No perioperative mortality occurred in neither groups and all of them underwent R0 resection.After operation,liver function recovered more quickly (Day 7 post-operation,AST:LLR 64.7;20.5 vs OLR 77.8±17.6 IU/L,P<0.05; ALT:LLR 72.2±16.3 vs OLR 86.4±23.2 IU/L,P<0.05).Fasting time and length of stay were much shorter (P<0.01) in LLR group with less sedatives or painkillers needed(P<0.01).No inter-group difference existed in the incidence of severe complications(P>0.05).The 3-year event-free survival was 75.0% for LLR and 76.9% for OLR.No inter-group difference existed.The reoperative rate was 5.9% for LLR and 3.8% for OLR respectively (P>0.05).Conclusion As a safe and feasible option for pediatric HB,LLR offers the advantages of minimal intraoperative trauma,faster recovery and no higher incidence of postoperative complications.And its short-term outcome is similar to that of OLR.However,long-term outcomes should be further evaluated.
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Memo
收稿日期:2019-09-01。
基金项目:创新人才推进计划-青年科技新星项目（编号：2018KJXX-050）
通讯作者:高亚,Email:ygao@mail.xjtu.edu.cn