Wang Fei,Yu Ling.Analysis of endocrine evaluation and surgical value of congenital micropenis[J].Journal of Clinical Pediatric Surgery,,18():849-853.[doi:10.3969/j.issn.1671-6353.2019.10.010]
Analysis of endocrine evaluation and surgical value of congenital micropenis
- Keywords:
- Micropenis; Endocrine; Penile Correction; Treatment Outcome
- CLC:
- R726.9;R697+.1;R58
- Abstract:
- Objective To elucidate the etiology of congenital micropenis in children,evaluate endocrine functions and explore the value of surgical treatments.Methods A total of 14 children with micropenis were recruited for karyotypic analysis and endocrine hormonal assessment.The gene mutations of 5α-reductase gene (SRD5A2),androgen receptor gene (AR) and steroid producing factor 1 (SF1) were detected selectively.Eleven of them underwent penile correction.Results Among them,chromosomal mutation was SRD5A2 (n=1) and SF1 (n=1).All provocation tests of gonadotropin-releasing hormone (GnRH) were normal,suggesting normal pituitary function.And provocation test of human chorionic gonadotropin (HCG) indicated testicular dysfunction (n=2).Among 11 cases of penile correction,the preoperative and postoperative penile lengths were (1.80±0.60) and (1.94±0.66) cm respectively and the difference was statistically significant (t=4.4,P<0.01); penile length was (1.81±0.64) cm at 1 year post-operation.As compared with pre-operation,the difference was not statistically significant (t=1,P=0.34).And the preoperative and postoperative glan sizes were (0.45±0.12) and (0.62±0.16) cm3 respectively and the difference was statistically significant (t=6.19,P=0.03); The postoperative glan size at 1 year post-operation was (0.61±0.11) cm3.As compared with pre-operation,the difference was statistically significant (t=8.25,P=0.01).Conclusion Endocrine assessment plays an important role in understanding the pathogenesis of micropenis and penile correction is necessary for normal penile development.And the long-term outcomes of penile correction for pediatric micropenis require further follow-ups.
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Memo
收稿日期:2018-10-08。
基金项目:上海市科学技术委员会医学引导计划（编号：15411966900）；上海市卫生健康委员会重要薄弱学科建设项目（编号：2016ZB0102）
通讯作者:余玲,Email:adele yuling@163.com