Shu Ye,Huang Wenya,Luo Yongqi,et al.Summary of clinical features and treatment protocols of 10 infants with Kasabach-Merritt syndrome[J].Journal of Clinical Pediatric Surgery,,18():775-778.[doi:10.3969/j.issn.1671-6353.2019.09.014]
Summary of clinical features and treatment protocols of 10 infants with Kasabach-Merritt syndrome
- Keywords:
- Kasabach-Merritt Syndrome; Hemangioma; Pathological Conditions; Signs and Symptoms; Therapy; Infant
- CLC:
- R726;R732.2
- Abstract:
- Objective To summarize the clinical treatments of infantile Kasabach-Merritt syndrome.Methods The clinical data were retrospectively analyzed for 10 hospitalized children with Kamei syndrome from January 2014 to September 2018.The treatment and treatment outcomes were summarized.Results All 10 cases fulfilled the diagnostic criteria of Kamei syndrome and occurred within 1 year post-birth,including 2 newborns.There were 5 boys and 5 girls.Hemangioma was located at head & face (n=6),trunk (n=2) and buttocks & vulva (n=2).In 4 cases,2 cases improved after treating with methylprednisolone while 2 cases were unhealed; 4 cases were treated with methylprednisolone and bleomycin embolization; 2 cases received methylprednisolone and vincristine.Conclusion With a young age of onset,Kasabach-Merritt syndrome has an aggressive course.Glucocorticoids are preferred for drug therapy and some patients with steroid resistance may be treated with steroid combined vincristine or bleomycin embolizayim.
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Memo
收稿日期:2018-10-19。
基金项目:湖南省医药卫生科研计划项目（编号：B2016039）
通讯作者:汤建萍,Email:jpingtang@126.com