Cheng Yingjie,Shan Ci,Shi Hanhan,et al.Research advances of MicroRNAs in the diagnosis,differential diagnosis and prognostic evaluation of hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,18():660-663.[doi:10.3969/j.issn.1671-6353.2019.08.009]
Research advances of MicroRNAs in the diagnosis,differential diagnosis and prognostic evaluation of hepatoblastoma
- Keywords:
- Hepatoblastoma; MicroRNAs; Biomarker; Molecular classification; Diagnosis; Prognostic Evaluation
- CLC:
- R735.7;R730.45;R730.7
- Abstract:
- As an extremely rare type of pediatric malignant carcinoma,hepatoblastoma (HB) is commonly found in boys aged under 5 years.It accounts for proximately 80% of primary malignant hepatic tumors in children.An abnormal elevation of α-fetoprotein (AFP) occurred only in 95% of HB children.And it was not significantly correlated with pathological type or tumor staging.There is some limitation for making the diagnosis,differential diagnosis and prognostic evaluation of hepatoblastoma merely through an abnormal elevation of AFP level.As demonstrated by many studies,playing important roles in the occurrence and development of HB,miRNAs had high levels of tissue specificity,conservatism and sequence and were specifically expressed in different pathological types of HB.Thus hopefully a combined biomarker of AFP and microRNAs may be utilized for molecular typing of HB.And HB fingerprint shall provide vital references for the diagnosis,differential diagnosis and prognostic evaluation of HB.
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Memo
收稿日期:2018-03-28。
基金项目:国家临床重点专科建设项目（编号：国卫办医函[2013]544号）；上海市科学技术委员会医学引导（编号：134119a7600）；上海交通大学"医工交叉研究基金"（编号：YG2015MS36）
通讯作者:顾松,Email:gusongscmc@163.com