Lv Zhibao,Sheng Qingfeng.Advances in the etiology, diagnosis and treatment of neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,,18():352-355.[doi:10.3969/j.issn.1671-6353.2019.05.003]
Advances in the etiology, diagnosis and treatment of neonatal necrotizing enterocolitis
- Keywords:
- Enterocolitis; Necrotizing/ET; Enterocolitis; Necrotizing/PC; Enterocolitis; Necrotizing/TH; Genomics; Infant; Newborn
- CLC:
- R722.1;R393
- Abstract:
- Necrotizing enterocolitis (NEC) is a leading cause of death from gastrointestinal disease in premature and low-birth-weight infants.Early detection of severely ischemic or necrotic bowel before perforation is rather difficult.New techniques including multi-omics contribute to better understanding its underlying mechanisms and discovering different categories of biomarkers.Combination of clinical metrics such as seven components of metabolic derangement (CMD) may provide accurate assessment of its severity.Implementation of quality improvement initiatives including breast milk feeding actually lowers its incidence.
References:
1 Qian T,Zhang R,Zhu L,et al.Chinese Collaborative Study Group for Neonatal Necrotizing Enterocolitis.Necrotizing enterocolitis in low birth weight infants in China:Mortality risk factors expressed by birth weight categories[J].Pediatr Neonatol,2017,58(6):509-515.DOI:10.1016/j.pedneo.2016.10.004.
2 Sheng Q,Lv Z,Xu W,et al.Short-term surgical outcomes of preterm infants with necrotizing enterocolitis:A single-center experience[J].Medicine (Baltimore),2016,95(30):e4379.DOI:10.1097/MD.0000000000004379.
3 王敏,沈淳.婴幼儿肠内营养物质吸收机制的研究进展[J].临床小儿外科杂志,2018,17(4):301-306.DOI:10.3969/j.issn.1671-6353.2018.04.014.Wang M,Shen C.Recent advance of enteral nutrition absorption mechanism for infants[J].J Clin Ped Surg,2018,17(4):301-306.DOI:10.3969/j.issn.1671-6353.2018.04.014.
4 Ng PC.An update on biomarkers of necrotizing enterocolitis[J].Semin Fetal Neonatal Med,2018,23(6):380-386.DOI:10.1016/j.siny.2018.07.006.
5 Shah BA,Migliori A,Kurihara I,et al.Blood level of inter-alpha inhibitor proteins distinguishes necrotizing enterocolitis from spontaneous intestinal perforation[J].J Pediatr,2017,180(2):135-140.e1.DOI:10.1016/j.jpeds.2016.09.016.
6 Ng EW,Poon TC,Lam HS,et al.Gut-associated biomarkers L-FABP,I-FABP,and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants[J].Ann Surg,2013,258(6):1111-1118.DOI:10.1097/SLA.0b013e318288ea96.
7 Ng PC,Chan KYY,Yuen TP,et al.Plasma miR-1290 is a novel and specific biomarker for early diagnosis of necrotizing enterocolitis-biomarker discovery with prospective cohort evaluation[J].J Pediatr,2019,205(1):83-90.e10.DOI:10.1016/j.jpeds.2018.09.031.
8 Chen S,Hu Y,Liu Q,et al.Comparison of abdominal radiographs and sonography in prognostic prediction of infants with necrotizing enterocolitis[J].Pediatr Surg Int,2018,34(5):535-541.DOI:10.1007/s00383-018-4256-y.
9 Goldstein SD,Beaulieu RJ,Niño DF,et al.Early detection of necrotizing enterocolitis using broadband optical spectroscopy[J].J Pediatr Surg,2018,53(6):1192-1196.DOI:10.1016/j.jpedsurg.2018.02.083.
10 Tepas JJ 3rd,Sharma R,Leaphart CL,et al.Timing of surgical intervention in necrotizing enterocolitis can be determined by trajectory of metabolic derangement[J].J Pediatr Surg,2010,45(2):310-313;discussion313-314.DOI:10.1016/j.jpedsurg.2009.10.069.
11 Gephart SM,Spitzer AR,Effken JA,et al.Discrimination of GutCheck(NEC):a clinical risk index for necrotizing enterocolitis[J].J Perinatol,2014,34(6):468-475.DOI:10.1038/jp.2014.37.
12 Arni D,Karam O,Vidal I,et al.Are Scores Reliable in Predicting the Need for Surgery and Mortality in Necrotizing Enterocolitis[J]? Eur J Pediatr Surg,2017,27(4):330-335.DOI:10.1055/s-0036-1593382.
13 Chan KY,Leung KT,Tam YH,et al.Genome-wide expression profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in human intestinal tissues:dysregulation of functional pathways[J].Ann Surg,2014,260(6):1128-1137.DOI:10.1097/SLA.0000000000000374.
14 Jung K,Koh I,Kim JH,et al.RNA-Seq for gene expression profiling of human necrotizing enterocolitis:a pilot study[J].J Korean Med Sci,2017,32(5):817-824.DOI:10.3346/jkms.2017.32.5.817.
15 Chatziioannou AC,Wolters JC,Sarafidis K,et al.Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis[J].Anal Bioanal Chem,2018,410(27):7163-7175.DOI:10.1007/s00216-018-1320-3.
16 Sylvester KG,Kastenberg ZJ,Moss RL,et al.Acylcarnitine profiles reflect metabolic vulnerability for necrotizing enterocolitis in newborns born premature[J].J Pediatr,2017,181(1):80-85.e1.DOI:10.1016/j.jpeds.2016.10.019.
17 Hair AB,Peluso AM,Hawthorne KM,et al.Beyond necrotizing enterocolitis prevention:improving outcomes with an exclusive human milk-based diet[J].Breastfeed Med,2016,11(2):70-74.DOI:10.1089/bfm.2015.0134.
18 Costeloe K,Hardy P,Juszczak E,et al.Bifidobacterium breve BBG-001 in very preterm infants:a randomised controlled phase 3 trial[J].Lancet,2016,387(10019):649-660.DOI:10.1016/S0140-6736(15)01027-2.
19 史婧奕,吕志宝.双歧杆菌三联活菌散预防早产儿坏死性小肠结肠炎的初步探讨[J].临床小儿外科杂志,2016,(1):72-75,87.DOI:10.3969/j.issn.1671-6353.2016.01.021.Shi JY,Lv ZB.Clinical study of preventing necrotizing enterocolitis in premature infants by bifido triple viable powder supplementation[J].J Clin Ped Surg,2016,15(1):72-75,87.DOI:10.3969/j.issn.1671-6353.2016.01.021.
20 Talavera MM,Bixler G,Cozzi C,et al.Quality improvement initiative to reduce the necrotizing enterocolitis rate in premature infants[J].Pediatrics,2016,137(5):e20151119.DOI:10.1542/peds.2015-1119.
21 Sheng Q,Lv Z,Cai W,et al.Human β-defensin-3 promotes intestinal epithelial cell migration and reduces the development of necrotizing enterocolitis in a neonatal rat model[J].Pediatr Res,2014,76(3):269-279.DOI:10.1038/pr.2014.93.
22 Sheng Q,Lv Z,Cai W,et al.Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats[J].J Pediatr Surg,2013,48(8):1697-1706.DOI:10.1016/j.jpedsurg.2012.11.038.
Memo
收稿日期:2019-02-23。
基金项目:国家自然科学基金资助项目（编号：81871194，81601322）
通讯作者:吕志宝,Email:lvzhibao@sohu.com