Yang Xiuzhen,Ye Jingjing,Li Xiaoying,et al.Value of ultrasonography in the diagnosis of skull lesions of Langerhans cell histiocytosis in children[J].Journal of Clinical Pediatric Surgery,,18():315-318.[doi:10.3969/j.issn.1671-6353.2019.04.013]
Value of ultrasonography in the diagnosis of skull lesions of Langerhans cell histiocytosis in children
- Keywords:
- Langerhans Cell Histiocytosis; Diagnosis; Ultrasonography; Child
- CLC:
- R729;R445.1;R593
- Abstract:
- Objective To explore the features and value of ultrasonography in diagnosing skull lesions of Langerhans cell histiocytosis in children.Methods The ultrasonographic findings of 19 cases of skull lesions of Langerhans cell histiocytosis were analyzed retrospectively.The ultrasonographic features were summarized and compared with the findings of computed tomography (CT) and magnetic resonance imaging (MRI).Results Twenty-five lesions in 19 cases were revealed by ultrasound.Four cases had multiple lesions.The sites were temporal (n=12),parietal (n=7),occipital (n=5) and buccal (n=1); Ultrasound revealed skull lesions involving inner and outer tables with sharp edge and irregular shape.The edge was ladder-like.Bone pieces could be visualized in 3 lesions.All lesions were accompanied by hypoechoic soft tissue mass and two had an echoless zone.Abundant blood flow signal could be visualized in masses; CT & MRI:19 cases underwent CT examination while 4 cases received MRI examination.Skull lesions were detected with soft tissue masses.One horacic lesion was detected by CT.Conclusion The skull lesions of Langerhans cell histiocytosis had characteristic ultrasonographic features.Ultrasonography may be helpful and preferred for initial evaluations of suspected skull lesions of Langerhans cell histiocytosis as it is non-invasive,radiation-free and inexpensive.
References:
1 Bakry OA,Samaka RM,Kandil MA,et al.Indeterminate cell histiocytosis with naive cells[J].Rare Tumors,2013,5(1):e13.DOI:10.4081/rt.2013.e13.
2 Shinsaku I,Naoko K,Akinobu M,et al.Langerhans cell histiocytosis with multifocal bone lesions:comparative clinical features between single and multi-systems[J].Int J Hematol,2009,90(14):506-512.DOI:10.1007/s12185-009-0420-4.
3 Wang HX,Nie P,Dong C,et al.Computed tomography and magnetic resonance imaging features of solitary Langerhans cell histiocytosis in calvaria[J].Int J Clin Exp Med,2017,2(10):3139-3146.
4 张斯佳,皇甫幼田,弓莉.颅骨郎格罕斯细胞组织细胞增生症的CT和MRI诊断[J].临床放射学杂志,2010,29(3):320-322.DOI:10.13437/j.cnki.jcr.2010.03.013. Zhang SJ,Huangfu YT,Gong Li.CT and MRI diagnosis of Langerhans’ cell histocytosis in skull[J].J Clin Radiol,2010,29(3):320-322.DOI:10.13437/j.cnki.jcr.2010.03.013.
5 Zhang LH,Jiang L,Yuan HS,et al.Atlantoaxial Langerhans cell histiocytosis radiographic characteristics and corresponding prognosis analysis[J].J Craniovert Jun Spine,2017,8(3):199-204.DOI:10.4103/jcvjs.JCVJS_21_16.
6 Lan ZG,Richard SA,Lei CF,et al.Thoracolumbar Langerhans cell histiocytosis in a toddler[J].JPS Case Reprots,2018,28(1):62-67.DOI:10.1016/j.epsc.2017.09.024.
7 Wojciech K,Maceij P,Dominik S,et al.Sonographic diagnosis and monitoring of localized Langerhans cell histiocytosis of the skull[J].J Clic Ultrasound,2013,41(3):134-139.DOI:10.1002/jcu.21988.
8 葛莉,冀园琦,齐翔,等.婴幼儿肌纤维瘤病复发1例[J].临床小儿外科杂志,2007,6(4):78.DOI:10.3969/j.issn.1671-6353.2007.04.035. Ge L,Ji YQ,Qi X,et al.Reucrrence of myofibromatosis in infants and toddlers[J].J Clin Ped Sur,2007,6(4):78.DOI:10.3969/j.issn.1671-6353.2007.04.035.
9 陈利军,陈士新,赵志友,等.儿童颅面骨转移性神经母细胞瘤的CT和MRI诊断[J].临床放射学杂志,2013,32(3):399-402.DOI:10.13437/j.cnki.jcr.2013.03.030. Chen LJ,Chen SX,Zhao ZY,et al.CT and MRI diagnosis of craniofacial bone metastases of neuroblastoma in children[J].J Clin Radiol,2013,32(3):399-402.DOI:10.13437/j.cnki.jcr.2013.03.030.
10 杜艳生.儿童神经母细胞瘤颅面骨转移的CT与磁共振成像表现分析[J].实用医学影像杂志,2016,17(5):450-451.DOI:10.16106/j.cnki.enl4-1281/r.2016.05.031. Du YS.CT and MRI manifestations of craniofacial bone metastases of neuroblastoma in children[J].JPMI,2016,17(5):450-451.DOI:10.16106/j.cnki.enl4-1281/r.2016.05.031.
Memo
收稿日期:2018-02-23。
基金项目:浙江省教育厅一般科研项目(编号:Y201737735)
通讯作者:叶菁菁,Email:6195005@zju.edu.cn