Hu JJ,Wang HM,Han W..Clinical diagnosis and treatment of focal nodular hyperplasia of liver in children.[J].Journal of Clinical Pediatric Surgery,,18():112-117.
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Clinical diagnosis and treatment of focal nodular hyperplasia of liver in children.

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第18卷 Number: 2019 02 Page: 112-117 Column: 论著 Date of publication: 2019-02-25
Author(s):
Hu JJ; Wang HM; Han W.
Department of Pediatric Oncological Surgery,National Center for Children’s Health;Beijing Children’s Hospital,Capital Medical University,Beijing 100045,China.
Keywords:
Children;  Surgery;  Liver Disease;  Radiology
CLC:
R729 R735.7 R857.3
Document code:
A
Abstract:
ObjectiveTo review the clinical features and management experiences of children with focal nodular hyperplasia (FNH) of liver.MethodsA review of medical records was conducted for 22 children pathologically diagnosed as FNH between January 2006 and January 2018.There were 9 boys and 13 girls with a median age of 54(7~133) months.All lesions were single and surgical resections performed.ResultsClinical manifestations included abdominal pain (n=7),abdominal bulge or mass (n=4) and detection by physical examination (n=11).And laboratory findings of abnormal liver function (n=8) and elevated alpha fetoprotein (AFP,n=3) were both restored postoperatively.Ultrasonography confirmed the diagnosis of FNH (n=10) with a correct rate of 45.5%.The misdiagnoses were hepatic hemangioma (n=5),hepatoblastoma (n=1) and mesenchymal hamartoma (n=1).Plain and enhanced computed tomography (CT) revealed 11/20 cases of FNH with a correct rate of proposed diagnosis at 55%.Three cases received preoperative magnetic resonance imaging (MRI).One case was diagnosed definitely as FNH while another two were diagnosed nondefinitely.The longest diameters of tumor were 5 to 15 cm with a median length of 8 cm.The maximal diameter of tumor was >10 cm (n=5) and the volume of the largest mass 15 cm×10 cm×8 cm.Central fibrovascular scar was found (n=11,50%).After a followup period of 0.5 to 10.8 years,all cases survived without recurrence or serious complications.ConclusionThe clinical and imaging features of FNH in children have some characteristics.The combined application of imaging methods,AFP and liver function test may improve the diagnostic accuracy.A definite diagnosis is dependent upon postoperative pathology examination and surgical resection can effectively remove the lesion.
Last Update: 2019-02-26