Duan Xingxing,Peng Ya,Liu Lingping,et al. Value of shear wave elastography in differentiating biliary atresia from cholestatic hepatitis in infants.[J].Journal of Clinical Pediatric Surgery,,17():821-825.
Value of shear wave elastography in differentiating biliary atresia from cholestatic hepatitis in infants.
Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R]
volume:
第17卷
Number:
2018 11
Page:
821-825
Column:
专题讨论
Date of publication:
2018-11-20
- Keywords:
- ; Biliary Atresia; Ultrasonography; Elastography; Infant
- Document code:
- A
- Abstract:
- ObjectiveTo explore the value of shear wave elastography (SWE) in differentiating biliary atresia (BA) from cholestatic hepatitis in infants aged under 90 days.MethodsSWE was employed for detecting hepatic Youngs modulus of 138 infants aged under 90 days with suspected cholestatic hepatitis.They were classified as BA and nonBA groups by surgical or pathological standard.The sensitivity,specificity,positive predictive value,negative predictive value,accuracy of different liver Youngs modulus in the diagnosis of BA were calculated by receiver operating characteristic curve (ROC).ResultsAmong them,51 cases were diagnosed as BA and another 87 cases nonBA.ROC analysis showed a cutoff value of 12.35 kPa for differentiating two groups.The area under ROC (AUROC) curve was 0.936 with the values of sensitivity,specificity,positive predictive value,negative predictive value and accuracy at 84.3%,89.7%,82.7%,90.7% and 87.7% respectively.Using the same cutoff value of 12.35 kPa,the sensitivity for diagnosing BA was 65.0%,94.7% and 100% in ≤30,31-60 and 61-90 day groups and the specificity 97.9%,89.3% and 54.5% respectively.ConclusionMeasuring hepatic stiffness in pediatric patients with jaundice by SWE is helpful to identify BA and SWE may be more sensitive for infants aged ＞30 days than those ≤30 days.
Last Update:
2018-11-23