hao Sijun,Zhang Mengping,Huang Min,et al.Clinical study of auditory function for children with obstructive sleep apnea-hypopnea syndrome before and after adenotonsillectomy[J].Journal of Clinical Pediatric Surgery,,17():677-683.
Clinical study of auditory function for children with obstructive sleep apnea-hypopnea syndrome before and after adenotonsillectomy
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- Abstract:
- Objective To explore the changes of auditory function in children aged from 4 to 7 years with obstructive sleep apnea hypopnea syndrome (OSAHS) and examine the influence of auditory function on children with medium-severe OSAHS after bilateral amygdala resection plus adenoidectomy under endoscopic ablation. Methods Children of varying degrees of OSAHS aged from 4 to 7 years were selected as research subjects. They were divided into mild, medium and severe OSAHS groups according to the results of polysomnography (PSG, n=40 each). Three groups were monitored by PSG for at least 7h and those with medium-severe OSAHS were re-operated under general anesthesia. The healthy control group was made up of 40 healthy children and their parents confirmed having no snoring or hearing-related history. The study group received PSG, pure tone audiometry (PTA), auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Cases of medium-severe OSAHS were re-examined by PSG, PTA, DPOAE and ABR for 6 months post-operation while healthy control group repeated ABR, DPOA and ABR. Multifactorial variance analysis was used for comparing the experimental data between groups. And t test was performed for the same group at pre and post-operation. Results Significant differences existed in PTA, ABR and DPOAE in cases of moderate-severe OSAHS (P < 0.05). And significant differences existed between mild OSAHS and healthy controls. No significant difference existed between PTA, ABR and DPOAE in those with mild OSAHS and healthy controls (P > 0.05). Conclusion Medium-severe OSAHS can impair listening function of children aged 4 to 7 years with middle and high-frequency hearing loss. The more advanced degree of OSAHS, the more severe listening function impairment.Bilateral amygdala resection plus adenoidectomy under endoscopic ablation of adenoid hypertrophy is efficacious for children with OSAHS and tonsil hypertrophy. It may improve cochlear function partially.
References:
1 Almendros I, Carreras A, Montserrat JM, et al. Potential role of adult stem cells in obstructive sleep apnea[J]. Front Neurol, 2012, 3:112. DOI: 10.3389/fneur.2012.00112. 2 Praud J. Snoring in children: Still many questions, only a few answers[J]. Pediatric Pulmonology, 2010, 37(S26):169-171. DOI: 10.1002/ppul.70095. 3 中华耳鼻咽喉头颈外科杂志编委会,中华医学会耳鼻咽喉科学分会.儿童阻塞性睡眠呼吸暂停低通气综合征诊疗指南草案(乌鲁木齐)[J].中华耳鼻咽喉头颈外科杂志,2007,42(2):83-84.DOI:10/3760/j.issn:1673-0860.2007.02.002. Editorial Board of Chinese Journal of Otolaryngology Head and Neck Surgery, Chinese Association of Otorhinolaryngology. Treatment Guidelines for Children with Obstructive Sleep Apnea Hypopnea Syndrome (Urumqi)[J]. Chinese Journal of Otolaryngology, Head and Neck Surgery, 2007, 42(2):83-84.DOI:10/3760/j.issn:1673-0860.2007.02.002. 4 中华医学会耳鼻咽喉科学分会. 阻塞性睡眠呼吸暂停低通气综合征诊断依据和疗效评定标准暨悬雍垂腭咽成形术适应证(杭州)[J]. 中华耳鼻咽喉头颈外科杂志, 2002, 37(6):403-404.DOI: 10.3760/j.issn:1673-0860.2002.06.002. Chinese Association of Otorhinolaryngology. Editorial Board of Chinese Journal of Otolaryngology Head and Neck Surgery, Diagnostic and Efficacy Evaluation Criteria for Obstructive Sleep Apnea Hypopnea Syndrome and Indications for Uvulopalatopharyngoplasty (Hangzhou)[J].. Chinese Journal of Otolaryngology. 2002, 37:403-404.DOI:10.3760/j.issn:1673-0860.2002.06.002. 5 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J]. 中华内科杂志, 2003, 15(3):192-195. Sleep Respiratory Disease Group of Respiratory Medicine Branch of Chinese Medical Association. Guidelines for Diagnosing and Treating Obstructive Sleep Apnea Hypopnea Syndrome (Draft). Chinese Journal of Tuberculosis and Respiratory Diseases, 2003, 15(3):192-195. 6 赵建林,郭献山,王林栋,等.阻塞性睡眠呼吸暂停低通气综合征与2型糖尿病周围神经病变的临床分析[J].中国医师进修杂志,2014,37(1):42-44.DOI:10.3760/cma.j.issn.1673-4904.2014.01.015. Zhao JL,Guo XS,Wang LD,et al. Clinical analysis of obstructive sleep apnea hypopnea syndrome and peripheral neuropathy in type 2 diabetes mellitus [J].Chinese journal of physician education,2014,37(1):42-44.DOI:10.3760/cma.j.issn.1673-4904.2014.01.015. 7 张东红, 王玉璟, 马秀岚. 沈阳市4028例幼儿园儿童声导抗听力检测结果分析[J]. 中国儿童保健杂志, 2013, 21(4):410-411. Zhang DH, Wang YJ, Ma XL, et al. Study of the results of tympanometry for 4028 preschool children in Shenyang[J]. Chinese Journal of Child Health, 2013, 21(4):410-411. 8 蔡燕娟, 夏荣, 卢永田. 护理干预对学龄前儿童纯音听阈测试的影响[J]. 吉林医学, 2013,34(30):6375-6376. Cai YJ, Xia R, Lu YT. Effect of nursing intervention on preschool children’s pure tone threshold test[J]. Jilin Medical Journal, 2013, 34(30):6375-6376. 9 丁大连,金晓杰.暂时性缺氧豚鼠耳蜗生物电的改变[J].耳鼻喉学报,1998,12(1) :4-6. Ding DL, Jin XJ. Temporary changes in cochlea bioelectricity in guinea pigs due to hypoxia[J]. Journal of Otolaryngology, 1998, 12(1):4-6. 10 张雷. 儿童阻塞性睡眠呼吸暂停低通气综合征的听功能评价[J]. 泰山医学院学报, 2015(12):82-84. DOI: 10.3969/j.issn.1004-7115.2015.12.008. Zhang L. Evaluation of hearing function in children with obstructive sleep apnea hypopnea syndrome[J]. Journal of Taishan Medical College, 2015(12):82-84.DOI:10.3969/j.issn.1004-7115.2015.12.008. 11 李熙星.持续正压通气治疗对重度OSAHS患儿听功能的影响[D].河北:河北医科大学,2016. Li XX. Effects of continuous positive pressure ventilation on hearing function of severe OSAHS patients[D]. Hebei: Hebei Medical University, 2016. 12 Nagy JL, Adelstein DJ, Newman CW, et al. Cisplatin ototoxicity: the importance of baseline audiometry.[J]. American Journal of Clinical Oncology, 1999, 22(3):305. 13 李倩庆, 宋江顺, 刘文婷. 听性脑干诱发电位结合单刺激听觉稳态诱发反应对正常青年人听阈正常值评估的探讨[J]. 中国耳鼻咽喉头颈外科, 2013, 20(6):295-297. Li QQ, Song JX, Liu WT. Evaluation of normal auditory threshold value of normal young people by auditory brainstem evoked potential plus single stimulus auditory steady-state evoked response[J]. Chinese Otolaryngology Head Neck Surgery, 2013, 20(6):295-297. 14 王会芳, 李连贺. 正常青年人 ASSR 和 click -ABR 与纯音听阈测定的相关性研究[J]. 医学美学美容旬刊, 2015(5):285-286. Wang HF, Li LH. Correlation between ASSR and click-abr in normal young adults and pure tone threshold measurement[J].Medical aesthetics, 2015,18(5):285-286. 15 王涛,梁建平,陆秋天,等.短声诱发听性脑干反应阈与不同听力构型纯音听阈相关性探讨[J].中国临床新医学, 2013,6(5):429-433.DOI: 10.3969/j.issn.1674-3806.2013.05.09. Wang T, Liang JP, Lu QT, et al. The correlation between the threshold of auditory brainstem response induced by short sound and the threshold of pure sound hearing of different hearing configurations was discussed[J].New Chinese clinical medicine,2013,6(5):429-433.DOI: 10.3969/j.issn.1674-3806.2013.05.09. 16 Fischer AQ, Chaudhary BA, Taormina MA, et al. Intracranial hemodynamics in sleep apnea[J].Chest,1992,102(5):1402-1406. DOI: 10.1378/chest.102.5.1402. 17 Cobb KM, Stuart A. Test-retest reliability of auditory brainstem responses to chirp stimuli in newborns[J]. International Audiology, 2014, 53(11):829-835. DOI: 10.3109/14992027.2014.932023. 18 Valderrama JT, De TA, Alvarez IM, et al. Auditory brainstem and middle latency responses recorded at fast rates with randomized stimulation.[J]. Journal of the Acoustical Society of America, 2014, 136(6):3233. DOI: 10.1121/1.4900832. 19 姜泗长, 阎承先. 现代耳鼻咽喉科学[M]. 天津科学技术出版社, 1999. Jiang SZ, Yan CX. Modern Otolaryngology[M]. Tianjin: Tianjin Science & Technology Press,1999. 20 王锐,唐旭华.重度OSAHS儿童手术前后听性脑干反应的临床研究[J].中国现代医生,2009,47(22):138-139.DOI: 10.3969/j.issn.1673-9701.2009.22.084. Wang R, Tang XH. Clinical study on auditory brainstem response in children with severe OSAHS before and after surgery[J]. Modern Chinese Doctor, 2009, 47(22):138-139.DOI:10.3969/j.issn.1673-9701.2009.22.084. 21 吴梅, 亚力坤?牙生. 两种方法联合评估新疆维吾尔族OSAHS患者的听觉功能[J]. 中山大学学报(医学科学版), 2014, 35(1):132-138. Wu M, Yalikun YS. Evaluate auditory function for OSAHS patients in Xinjiang Uyghur nationality via two methods[J]. Journal of Sun Yat-sen University (Medical Science Edition), 2014, 35(1):132-138. 22 邵渊,安燕,张少强.畸变产物耳声发射在听力正常的耳鸣患者中的应用[J].山西医科大学学报,2013,44(1):66-68.DOI:10.3969/J.ISSN.1007-6611.2013.01.021. Shao Y, An Y, Zhang SQ. The application of distortion product otoacoustic emission in patients with normal hearing tinnitus[J]. Journal of Shanxi Medical University, 2013,44(1):66-68.DOI:10.3969/J.ISSN.1007-6611.2013.01.021. 23 王洪田,钟乃川.畸变产物耳声发射对侧抑制效应的临床应用价值[J].临床耳鼻咽喉科杂志,1999,13(1):3-5.DOI:10.3969/j.issn.1001-1781.1999.01.001. Wang HT, Zhong NC. Clinical application value of distortion product otoacoustic emission on lateral inhibition effect[J]. Journal of Clinical Otolaryngology, 1999,13(1):3-5.DOI:10.3969/j.issn.1001-1781.1999.01.001. 24 洪志军,刘秀丽,翟立杰.畸变产物耳声发射在职业噪声性聋早期检测中的作用[J].中国耳鼻咽喉头颈外科,2013,20(6):291-293. Hong ZJ, Liu XL, Qu LJ. Role of distortion product otoacoustic emission in early detection of occupational noise-induced deafness[J]. Chinese Otolaryngology Head Neck Surgery, 2013, 20(6):291-293. 25 佘万东,张倩,钱晓云,等.重度阻塞性睡眠呼吸暂停低通气综合征耳蜗功能的临床观察[J].听力学及言语疾病杂志,2002,10(4):232-234.DOI:10.3969/j.issn.1006-7299.2002.04.009. She WD, Zhang Q, Qian XY, et al. Clinical observation on cochlea function in severe obstructive sleep apnea hypopnea syndrome[J]. Journal of Audiology & Speech Disorders, 2002,10(4):232-234.DOI:10.3969/j.issn.1006-7299.2002.04.009.