Zheng Jia,Li Zhongzhi,Li Xiaofeng,et al.Prevention of thrombosis after total cavopulmonary anastomosis:a singlecenter study.[J].Journal of Clinical Pediatric Surgery,,17():354-357.
Prevention of thrombosis after total cavopulmonary anastomosis:a singlecenter study.
Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R]
volume:
第17卷
Number:
2018 05
Page:
354-357
Column:
论著
Date of publication:
2018-05-28
- Keywords:
- Total cavopulmonary anastomosis; Thrombosis; Aspirin; Warfarin
- Document code:
- A
- Abstract:
- ObjectiveTo compare the preventive effects of warfarin versus aspirin for thrombosis after total cavopulmonary anastomosis (Fontan).MethodsFrom February 2004 to December 2016,a total of 37 Fontan procedures were performed.The average age was (7.32±2.25) (3.5-12) years and the average age weight(23.58±4.25) (11.5-41) kg.Two groups were designated as warfarin group 0.06 mg·kg-1·d-1 (n=14) and aspirin group 5 mg·kg-1·d-1 (n=23).ResultsImmediate after operation 3 day chest and pericardium drainage:warfarin (17.33±5.62) vs aspirin (19.27±6.49) ml/kg,no statistical significance (t=0.305,P=0.633);blood transfusion:warfarin (15.18±4.73) vs aspirin (13.52±3.29) ml/kg,no statistical significance (t=0.718,P=0.452);within 3 years thrombotic events,warfarin (n=1) and aspirin (n=2),no statistical significance (χ2=0.028,P=0.867);total thrombotic events:warfarin(n=2) vs aspirin (n=2),no statistical significance (χ2=0.026,P=0.595);allcause mortality:warfarin (n=2) vs aspirin (n=3),no statistical significance (χ2=0.011,P=0.914).ConclusionFor juvenile and youth Fontan patients without atrial fibrillation,aspirin or warfarin shall obtain comparable effect of preventing thrombosis.Antiplatelet therapy is recommended.Avoiding frequent monitoring INR blood tests of warfarin,the compliance of patients and their families is better.
Last Update:
2018-05-23