YIN Min-zhi,CHEN Qi-min,ZHANG Zhong-de,et al.he analysis of paediatric inflammatory myofibroblastic tumor’s clinicopathological features,lectures review[J].Journal of Clinical Pediatric Surgery,,12():97-99.[doi:10.3969/j.issn.1671— 6353.2013.02.006]
he analysis of paediatric inflammatory myofibroblastic tumor’s clinicopathological features,lectures review
- Keywords:
- Neoplasms; Muscle Tissue/PA; Myositis; Child
- Abstract:
- Objetive To explore the clinicopathological features of inflammatory myofibroblastic tumor(IMT)and investigate the diagnosis and treatment. Methods 4 cases of children’s IMT were analyzed with HE stain and immunohistochemical technique, the literatures were reviewed. Results one was a girl and the other 3 were boys, the mean age were 3 years-old, laboratory findings no significant, histological showed the tumor was composed of(myo)/ fibrobastic spindle cells with inflammatory cells. Immunohistochemical examination of the tumors were as follows: vimentin、ALK1, and variably were positive,and Desmin、SMA、MSA were sported, positive, S100 was negative. Conclusions IMTs is a rare spindle cells in an inflammatory background.The clinical characteristics is no significant, histological examination combined with immunohistochemical study can discover the exactly diagnosis. Surgery is the main treatment modility. And because of its local invasiveness and its tendency to recur, a careful follow-up is required.
References:
1 Pettinato G, Manivel JC, De Rosa N, et al. Inflammatory myofibroblastic tumor(plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations[J]. Am J Clin Pathol, 1990, 94(5):53 8— 546. 2Pisciotto PT, Gray GF Jr, Miller DR. Abdominal plasma cell pseudotumor[J]. J Pediatr, 1978, 93(4):62 8— 630. 3Coffin CM, Watterson J, Priest JR, et al. Extrapulmonary inflammatory myofibroblastic tumor(inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 8 4cases[J]. Am J Surg Pathol. 1995,19(8):85 9— 872. 4Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum.A tumor closely simulating inflammatory pseudotumor[J]. Am J Surg Pathol, 1991, 15(12):114 6— 1156. 5Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor:comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases[J].Am J Surg Pathol, 2007,31(4):50 9— 520. 6Yee CH, To KF, Hou SM, et al. Inflammatory Myofibroblastic Tumor of Spermatic Cord in Undescended Testis[J]. Urology, 2009,73(6):1423. 7Fletcher CD,Unni KK,Mertens F,et al. World Health Orgnization Classification of Tumours.Pathology and Genetics of Tumours of Soft Tissue and Bone[J].Lyon:IARC Press,2002. 8Gupta CR, Mohta A, Khurana N, et al. Inflammatory pseudotumor of the omentum: an uncommon pediatric tumor[J]. Indian J Pathol Microbiol, 2009,52(2):21 9— 221. 9Sodhi KS, Virmani V, Bal A, et al. Inflammatory pseudotumor of the omentum[J]. Indian J Pediatr, 2010, 77(6):68 7— 688. 10Koirala R, Shakya VC, Agrawal CS, et al. Retroperitoneal inflammatory myofibroblastic tumor[J]. The American Journal of Surgery,2010,199(2):e1 7— 19. 11林建韶,张建民,惠京,等. 炎症性肌纤维母细胞瘤及低度恶性肌纤维母细胞肉瘤[J]. 临床与实验病理学杂志,2007,23(4):38 5— 388. 1 2Palma DA, Loizzi D, Sollitto F, et al. Surgical treatment of a rare case of tracheal inflammatory pseudotumor in pediatric age[J]. Interact Cardiovasc Thorac Surg, 2009, 9(6):103 5— 1037. 1 3Qiu X, Montgomery E, Sun B. Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts[J]. Human Pathology, 2008,39(6):84 6— 856. 1 4Stelow EB, Shami VM, Moskaluk CA, et al. Esophageal inflammatory myofibroblastic tumor sampled by EUS-FNA[J]. Gastrointestinal Endoscopy,2010,72(1):20 9— 210. 1 5Yeh YS, Ma CJ, Yang SF, et al.Inflammatory Myofibroblastic Tumor of the Ileum Causing an Unusual Ileocecal Intussusception[J]. Fooyin J Health Sci, 2010,2(1):3 6— 39. 1 6Jung SH, Yima SH, Hua HJ, et al. Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor[J]. Lung Cancer,2010,70(2):15 2— 157.