[Liu Pei, Song Hongcheng]
[Absract] Objective
Over the last two decades,surgical philosophy for disorders of sex development (DSD) has shifted from traditional anatomical ¡¯normalization¡¯ during infancy to a patient-centered,individualized treatment model emphasizing multidisciplinary team collaboration.Currently,non-standardized practices regarding therapeutic principles and the timing of surgical interventions for pediatric DSD have remained prevalent.Through integrating the relevant domestic and international literatur...
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[Liu Xin, Yang Yi]
[Absract] Objective
Disorders of sex development are a large group of conditions involving abnormalities in genes,chromosomes,gonads and genital anatomy.Frequently associated with multiple systemic abnormalities,they present with diverse clinical manifestations and entail a high need for psychological supports for both children and their families.Due to their complexity,a multidisciplinary team (MDT) model has been recommended as a gold standard for managing individuals with disorders of sex dev...
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[Xu Hongxiang1, Dong Rui2, Zhang Jun1]
[Absract] Objective
With advances in medical technology and the changing pediatric disease spectrum,totally implantable venous access ports (TIVAPs) have been widely used in children.To further standardize the clinical practice of totally implantable venous access ports (TIVAPs) in children, the Children¡¯s Hospital of Chongqing Medical University and Children¡¯s Hospital of Fudan University took the lead in organizing 25 national specialists engaged in pediatric TIVAP management. Focusing on the ...
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[Liang Haiyan, Liu Pei, Wen Xu, Yang Yang, Li Jiayi, Wang Guannan, Zhang Weiping, Sun Ning, Song Hongcheng]
[Absract] Objective
Objective To summarize the clinical characteristics and diagnostic and therapeutic experiences of children with ovotesticular disorder of sex development (OT-DSD),aiming to deepen the understanding of this disease and optimize clinical management strategies. Methods A retrospective clinical study was conducted for 55 children diagnosed with OT-DSD by gonadal biopsy from January 2016 to October 2025.The relevant clinical data included social sex,age,clinical ...
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[Liang Yan1,2, Lyu Yiqing1,2, Xu Zihan1, Huang Yichen1, Li Pin2,3, Chen Fang1,2]
[Absract] Objective
Objective To explore the relationship between second-to-fourth digit ratio (2D:4D) and sex hormone levels during masculinization programming window (MPW) through analyzing children with different types of disorders of sex development (DSD) and evaluate the potential value of 2D:4D as an auxiliary diagnostic indicator for DSD. Methods For this prospective study,137 DSD children hospitalized from October 2023 to February 2026 were enrolled as observation group...
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[Hu Jianjun, Zhao Yaowang, Chen Yifu, He Jun, He Tianqu, Nie Youneng]
[Absract] Objective
Objective To explore the risk factors for postoperative complications after urethroplasty in children with disorders of sex development (DSD) after male gender reassignment and provide references for optimizing clinical management strategies and lowering the incidence of complications. Methods The relevant clinical data were retrospectively reviewed for 60 DSD children undergoing urethroplasty for male gender reassignment from April 2021 to December 2024.The...
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[Mi Jinwen, Ding Yanjun, Wu Dacheng, Cui Kongkong, Hong Yifan, Wen Sheng, Zhang Deying, Hua Yi, Lin Tao, Liu Xing, Wu Shengde, Wei Yuexin, Wei Guanghui]
[Absract] Objective
Objective To explore the correlation between clinical phenotypes and genotypes in 46,XY disorders of sex development (DSD). Methods Clinical and genetic testing data were retrospectively reviewed for 101 children of 46,XY DSD from January 2020 to January 2026.They were grouped based upon genetic testing results and their clinical phenotypes compared. Results The positive rate of genetic testing was 78.2%(79/101) with a diagnostic yield of 56.4%(57/101...
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[Liu Wen, Liu Pei, Liang Haiyan, Song Hongcheng, Zhang Weiping]
[Absract] Objective
Objective To summarize the clinical characteristics of ovotesticular disorder of sex development (OT-DSD) with transverse gonad ectopia. Methods For this case series,the authors retrospectively reviewed OT-DSD complicated by transverse ectopia (OTTE) hospitalized between January 2015 and January 2026.The following clinical data were collected:initial presentation,external masculinization score (EMS),assigned gender,sex hormone and stimulation tests,anti-M¨¹ll...
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[Wang Juping, Yan Yingnan, Zhao Fangzheng, Wang Yang]
[Absract] Objective
Objective To explore the expression profile of circular RNA hsacirc_049751 in Hirschsprung¡¯s disease (HSCR) tissues and preliminarily examine its potential molecular regulatory mechanisms. Methods High-throughput RNA sequencing (Illumina HiSeq) was performed on intestinal tissues from HSCR children and normal controls to identify differentially expressed circRNAs.The expression of hsacirc_049751 was further validated in an expanded cohort by quantitative rea...
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[Liang Mingzhou, Li Yang, Liu Xiaoyang]
[Absract] Objective
Objective To systematically evaluate the efficacy of hollow screws versus locking compression hip plate for displaced pediatric femoral neck fractures using meta-analysis. Methods The relevant literature published from database inception to July 30,2025,comparing cannulated screws with pediatric hip locking compression plate (LCP-PHP) for displaced pediatric femoral neck fractures was systematically searched across the following databases of China National K...
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[He Yuanfei, Qi Shiqin, Wei Decheng, Zhou Chengxiao]
[Absract] Objective
Objective To evaluate the feasibility and clinical efficacy of single-port laparoscopic suspension in resecting small intestinal duplication in children. Methods For this retrospective cohort study,the relevant clinical data were collected from 33 children undergoing resection of small intestinal duplication between January 2021 and December 2024.Based upon specific surgical approaches,they were assigned into two groups of single-port laparoscopic suspension...
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[Wu Bichen1, Li Li2, Meng Yanni1, Yang Guangxian3]
[Absract] Objective
Objective To summarize the clinical characteristics,diagnostic approaches and therapeutic experiences of pediatric pleuropulmonary blastoma (PPB) and boost the understanding and early diagnostic capability of this disease. Methods A retrospective analysis was conducted for the relevant clinical data from 8 children with pathologically confirmed PPB presenting with respiratory symptoms as an initial manifestation from September 2018 to December 2025.Clinical ...
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[Zhou Haiyin1, Chen Yukun1, Chen Yanying1, Liu Pingping1, Zhu Guanghui2]
[Absract] Objective
Objective To explore the clinical characteristics,gene mutation features and imaging evolutions of fibrodysplasia ossificans progressiva (FOP) in children and summarize its research advances of the disease through a literature review to provide rationales for early clinical diagnosis and standardized treatment. Methods A retrospective analysis was conducted for the relevant clinical data of three male FOP children hospitalized from January 2020 to December 2...
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[Pan Wenjing, Zhao Jindu, Gao Qun]
[Absract] Objective
Objective To develop a prognostic signature based upon ferroptosis-related genes (FRGs) for soft tissue sarcoma (STS),aiming to provide theoretical rationales for prognostic assessments and personalized treatments. Methods This study was conducted using a retrospective cohort analysis based upon public databases plus in vitro cell experiments.Transcriptomic and clinical data from the TCGA-SARC dataset within the item of sarcoma of The Cancer Genome Atlas (TC...
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[Xia Aochun1, Duan Xufei2, Yan Xueqiang2]
[Han Runze, Yang Zesheng, Pei Guanghua, Xie Xiaoying]
[Zhu Yufei, Xie Hua, Tang Weibing]
[Absract] Objective
As one of infantile bile duct diseases,biliary atresia (BA) is characterized by phlogistic obstruction of external bile duct and progressive liver fibrosis.Biliary epithelial cell (BEC) is a critical cell type during BA immune response.With barrier function of regulating innate immune response,it can also induce excessive immune activation to accelerate the inflammatory response after injury.In addition,immune system dysfunction may disrupt BEC,leading to the occurrence and p...
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