Chen Xintong,Jiang Weiwei.Research advances in Reg3g-mediated regulation of intestinal homeostasis[J].Journal of Clinical Pediatric Surgery,2026,(07):689-692.[doi:10.3760/cma.j.cn101785-202401067]
Reg3g调控肠道内环境稳态的研究进展
- Title:
- Research advances in Reg3g-mediated regulation of intestinal homeostasis
- 摘要:
- 再生胰岛来源蛋白3γ(regenerating islet-derived protein 3 gamma,Reg3g)是一种非钙依赖性C型凝集素样抗菌蛋白。Reg3g可通过调节肠道菌群组成、维持黏膜与菌群的空间隔离、调控炎症反应以及促进上皮屏障修复等方式,参与肠道生物屏障、免疫屏障和机械屏障稳态的维持。短肠综合征(short bowel syndrome,SBS)是因大量小肠切除或旷置后肠道有效吸收面积显著减少所导致的一系列营养吸收障碍性综合征。Reg3g对肠道内环境稳态的调控作用,提示 Reg3g 可能成为调控肠道微生态与屏障稳态、改善 SBS 肠道功能障碍的重要潜在靶点。本文就Reg3g在肠道稳态中的作用及其相关信号通路进行综述。
- Abstract:
- Regenerating islet-derived protein 3 gamma (Reg3g) is a calcium-independent C-type lectin-like antimicrobial protein.It contributes to the maintenance of intestinal homeostasis through modulating the composition of gut microbiota,preserving spatial segregation between microbiota and intestinal mucosa,regulating inflammatory responses and promoting epithelial barrier repair.Short bowel syndrome (SBS) is manifested by a marked reduction in functional intestinal absorptive surface area after extensive small bowel resection,intestinal exclusion or congenital intestinal shortening,resulting in disorders of nutrient,water and electrolyte absorption.SBS children present frequently with gut dysbiosis,mucosal inflammation and impaired barrier function.Therefore Reg3g-mediated regulation of intestinal homeostasis may provide a potential therapeutic target for improving intestinal barrier dysfunction and microbial imbalance in pediatric SBS.This review summarized the structural characteristics of Reg3g and discussed its role in intestinal homeostasis and the related signaling pathways.
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备注/Memo
收稿日期:2024-1-30。
基金项目:江苏省卫健委面上项目(2022037);江苏省卫健委高层次卫生人才"六个一工程"拔尖人才项目资助(GY2020019)
通讯作者:蒋维维,Email:wwjiang@njmu.edu.cn