Gao Wei.Expanding the sources of donor pool for pediatric liver transplantation[J].Journal of Clinical Pediatric Surgery,2022,21(05):405-409.[doi:10.3760/cma.j.cn101785-202203014-002]
扩大儿童肝脏移植供体来源途径
- Title:
- Expanding the sources of donor pool for pediatric liver transplantation
- Keywords:
- Liver Transplantation/MT; Living Donors/CL; Living Donor Liver Transplantation; Split Liver Transplantation; Extended Criteria Donor
- 摘要:
- 肝脏移植是儿童终末期肝病以及部分代谢性疾病的有效治疗方法,目前对供体的需求量远远超过实际可获得的供体肝脏数量。在儿童肝脏移植领域,由于缺少年龄及大小匹配的肝脏,儿童肝脏移植候选受者的死亡率高于成人肝脏移植候选受者。随着肝移植技术水平的提高,目前扩大标准供体的使用越来越多(扩大标准供体是指过去认为不能用的供体,经供体可用的标准扩大以后认为其可使用、但存在一定风险的一类供体;在过去扩大标准供体也被称为边缘供体,近些年由于供体短缺问题严重,边缘供体的使用呈现逐渐增多的趋势),新型肝移植手术方式的应用也越来越广泛,且效果满意。本文将系统阐述扩大儿童肝脏移植供体来源的途径。
- Abstract:
- Liver transplantation remains a curative treatment for end-stage liver disease and some con- genital metabolic abnormalities. While a growing demand for donor livers far exceeds the supply, waitlist mortali- ty for liver transplant candidates remains critical. Lacking age/size-matched organs results in a higher waitlist mortality in pediatric candidates than adults. More extended criteria donors and new transplant techniques are currently employed. And the feasibility and safety have been thoroughly evaluated.
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备注/Memo
收稿日期:2022-3-4。
基金项目:国家自然科学基金项目（82170672）
通讯作者:高伟,Email:gaowei_tjfch@163.com