[1]夏强,朱欣烨.儿童肝移植发展现状及展望[J].临床小儿外科杂志,2022,21(05):401-404.[doi:10.3760/cma.j.cn101785-202202028-001]
　Xia Qiang,Zhu Xinye.Current development and future outlook of pediatric liver transplantation[J].Journal of Clinical Pediatric Surgery,2022,21(05):401-404.[doi:10.3760/cma.j.cn101785-202202028-001]
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儿童肝移植发展现状及展望

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第21卷 期数: 2022年05期 页码: 401-404 栏目: 述评 出版日期: 2022-05-01
Title:
Current development and future outlook of pediatric liver transplantation
作者:
夏强1; 2; 3;  朱欣烨1
1 上海交通大学医学院附属仁济医院肝脏外科, 上海 200127;
2 上海市器官移植研究所, 上海 200127;
3 上海市器官移植与免疫工程技术研究中心, 上海 200127
Author(s):
Xia Qiang1; 2; 3;  Zhu Xinye1
1 Department of Liver Surgery, Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;
2 Shanghai Institute of Organ Transplantation, Shanghai 200127, China;
3 Shanghai Research Center of Organ Transplantation & Immune Engineering Technology, Shanghai 200127, China
关键词:
肝移植; 活体供者/分类; 疾病管理; 随访研究; 出院后医疗; 儿童
Keywords:
Liver Transplantation; Living Donors/CL; Disease Management; Follow-Up Studies; Af- tercare; Child
DOI:
10.3760/cma.j.cn101785-202202028-001
摘要:
全球首例儿童肝移植的开展距今已近60年。随着儿童肝移植技术及术后管理经验的提升,全球范围内儿童肝移植手术例数稳步上升,手术质量逐步提高。发达国家儿童肝移植起步早,积累深,在治疗理念、患儿及移植物长期管理等方面更为成熟。中国大陆地区儿童肝移植起步晚,但近年来发展迅速。本文阐述国内外儿童肝移植发展概况及存在的重点问题。
Abstract:
It has been over 60 years since the first global case of pediatric liver transplantation. With continuous refinements of surgical techniques and post-surgical management of pediatric liver transplantation, the number of surgeries is steadily rising while surgical quality is gradually greater. Such developed countries as Europe, USA, Japan and South Korea have enjoyed an early start and accumulated rich experiences of treatment discipline and long-term management of patients and grafts. Pediatric liver transplantation in Chinese mainland began late but has been rapidly developing in recent years. This review summarized the overall development and focused upon key issues of domestic and foreign pediatric liver transplantations.

参考文献/References:

[1] 万平, 夏强. 小儿肝移植的进展与前沿[J]. 实用器官移植电子杂志,2017,5(1):7. DOI:10. 3969/j. issn. 2095-5332. 2017. 01. 003. Wang P, Xia Q. Recent advances and cutting edges of pediatric liver transplantation[J]. Practical Journal of Organ Transplantation (Electronic Version),2017,5(1):7. DOI:10. 3969/j. issn. 2095-5332. 2017. 01. 003.
[2] Kasahara M, Umeshita K, Eguchi S, et al. Outcomes of pediatric liver transplantation in japan:a report from the registry of the Japanese liver trans- plantation society[J]. Transplantation,2021,105(12):2587-2595. DOI:10. 1097/TP. 0000000000003610.
[3] Adam R, Karam V, Cailliez V, et al. 2018 Annual report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplan- tation[J]. Transpl Int,2018,31(12):1293-1317. DOI:10. 1111/tri. 13358.
[4] de Ville de Goyet J, Baumann U, Karam V, et al. European Liver Transplant Registry:Donor and transplant surgery aspects of 16,641 liver trans- plantations in children[J]. Hepatology,2022,75(3):634-645. DOI:10. 1002/hep. 32223.
[5] Wan P, Xu D, Zhang J, et al. Liver transplantation for biliary atresia:A nationwide investigation from 1996 to 2013 in mainland China[J]. Pediatr Transplant,2016,20(8):1051-1059. DOI:10. 1111/petr. 12750.
[6] Kim JM, Kim KM, Yi NJ, et al. Pediatric liver transplantation outcomes in Korea[J]. J Korean Med Sci, 2013, 28(1):42-47. DOI:10. 3346/jkms. 2013. 28. 1. 42.
[7] Miller CM, Quintini C, Dhawan A, et al. The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline[J]. Transplantation,2017,101(5):938-944. DOI:10. 1097/TP. 0000000000001571.
[8] Chaubal G, Nanavati AJ, Biradar V, et al. Monosegment liver allografts for liver transplantation in infants weighing less than 6 kg:an initial indian experience[J]. Transplant Proc,2021,53(5):1670-1673. DOI:10. 1016/j. transproceed. 2021. 01. 005.
[9] Wan P, Li Q, Zhang J, et al. Right lobe split liver transplantation versus whole liver transplantation in adult recipients:A systematic review and meta-analysis[J]. Liver Transpl,2015,21(7):928-943. DOI:10. 1002/lt. 24135.
[10] Hackl C, Schmidt KM, Süsal C, et al. Split liver transplantation:current developments[J]. World J Gastroenterol,2018,24(47):5312-5321. DOI:10. 3748/wjg. v24. i47. 5312.
[11] Wanis KN, Sarvet A, Ruffolo LI, et al. Estimating the effect of increasing utilization of living donor liver transplantation using observational data[J]. Transpl Int,2021,34(4):648-656. DOI:10. 1111/tri. 13835.
[12] Suarez-Pierre A, Choudhury R, Carroll AM, et al. Measuring the effect of the COVID-19 pandemic on solid organ transplantation[J]. Am J Surg, 2021, S0002-9610(21) 00784-4. DOI:10. 1016/j. amjsurg. 2021. 12. 036.
[13] Muhammad H, Zaffar D, Tehreem A, et al. An update on usage of high-risk donors in liver transplantation[J]. J Clin Med, 2021, 11(1):215. DOI:10. 3390/jcm11010215.
[14] Da BL, Ezaz G, Kushner T, et al. Donor characteristics and regional differences in the utilization of HCV-positive donors in liver transplantation[J]. JAMA Netw Open,2020,3(12):e2027551. DOI:10. 1001/jamanetworkopen. 2020. 27551.
[15] Herlenius G, Larsson M, Ericzon BG. FAP World Transplant Register and domino/sequential register update[J]. Transplant Proc,2001,33(1-2):1367. DOI:10. 1016/s0041-1345(00) 02513-6.
[16] Geyer ED, Burrier C, Tumin D, et al. Outcomes of domino liver transplantation compared to deceased donor liver transplantation:a propensity-matc- hing approach[J]. Transpl Int,2018,31(11):1200-1206. DOI:10. 1111/tri. 13291.
[17] Kasahara M, Sakamoto S, Fukuda A. Pediatric living-donor liver transplantation[J]. Semin Pediatr Surg,2017,26(4):224-232. DOI:10. 1053/j. sempedsurg. 2017. 07. 008.
[18] Sun Y, Jia L, Yu H, et al. The effect of pediatric living donor liver transplantation on neurocognitive outcomes in children[J]. Ann Transplant, 2019,24:446-453. DOI:10. 12659/AOT. 914164.
[19] Molema F, Martinelli D, H?rster F, et al. Liver and/or kidney transplantation in amino and organic acid-related inborn errors of metabolism:An o- verview on European data[J]. J Inherit Metab Dis,2021,44(3):593-605. DOI:10. 1002/jimd. 12318.
[20] Van Arendonk KJ, King EA, Orandi BJ, et al. Loss of pediatric kidney grafts during the " high-risk age window":insights from pediatric liver and simultaneous liver-kidney recipients[J]. Am J Transplant,2015,15(2):445-452. DOI:10. 1111/ajt. 12985.

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备注/Memo

收稿日期:2022-1-21。
基金项目:上海申康三年行动计划（SHDC2020CR2003A）
通讯作者:夏强,Email:xiaqiang@shsmu.edu.cn

更新日期/Last Update: 1900-01-01