Zhao Yilin,Wang Haojie,Zhan Jianghua.Recent advances of TGFβ1 induced EMT-related signaling pathways in biliary atresia[J].Journal of Clinical Pediatric Surgery,2021,20(12):1189-1193.[doi:10.12260/lcxewkzz.2021.12.017]
胆道闭锁TGFβ1诱导EMT相关通路研究进展
- Title:
- Recent advances of TGFβ1 induced EMT-related signaling pathways in biliary atresia
- Keywords:
- Biliary Atresia/ET; Epithelial-Mesenchymal Transition; Transforming Growth Factor Beta1; Liver Cirrhosis
- 分类号:
- R722.1;R657.4
- 摘要:
- 胆道闭锁（biliary atresia，BA）是以肝内外胆管进行性炎症及纤维化为特征的疾病，其发病原因不明，可能与病毒感染、免疫损伤有关。BA确诊后应先行Kasai手术，部分患者可恢复胆流，但纤维化过程并没有停止且影响BA预后。上皮-间质转化（epithelial-mesenchymal transition，EMT）参与肝纤维化过程，EMT在外界因素刺激下，极化的上皮细胞逐渐松解，转化成为具有间质细胞特征的细胞，导致肝纤维化进一步加重。转化生长因子-β1（transforming growth factor-β1，TGFβ1）可诱导上皮-间质转化，其诱导EMT通过TGFβ1/Smad通路及不依赖Smad的其他TGFβ1信号通路。微小RNA可影响相关信号通路参与肝纤维化进程。本文将阐述BA中TGFβ1诱导EMT信号通路的研究进展，为抑制甚至逆转EMT进程、延缓肝纤维化提供思路。
- Abstract:
- Biliary atresia (BA) is a disease characterized by progressive inflammation and fibrosis of intra/extrahepatic bile ducts.The cause of disease has remained elsusive.It may be related with virus infection and immune response.The major treatment for BA is Kasai surgery while liver fibrosis is an important factor affecting the prognosis of Kasai surgery.Involved in the process of liver fibrosis, epithelial-mesenchymal transition (EMT) refers to that polarized epithelial cells are released gradually and transformed into cells with mesenchymal characteristics under stimulation.Transforming growth factor-β1 (TGFβ1) induces EMT through TGFβ1/Smad signaling pathway and other TGFβ1/non-Smad signaling pathways.And microRNA affects signaling pathways and participates in the process of liver fibrosis.This review was intended to elaborate the possible pathways associated with TGFβ1 inducing EMT in BA and to provide rationales for delaying liver fibrosis and inhibiting or even reversing EMT process.
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备注/Memo
收稿日期:2020-04-30。
基金项目:国家自然科学基金（编号：81570471）；天津市卫生行业重点攻关项目（编号：14KG129）；新疆维吾尔自治区自然科学基金（2019D01A12）
通讯作者:詹江华,Email:zhanjianghuatj@163.com