[1]孙雪,任红霞.胆道闭锁发生与肝纤维化的分子机制研究进展[J].临床小儿外科杂志,2019,18(05):432-436.[doi:10.3969/j.issn.1671-6353.2019.05.019]
 Sun Xue,Ren Hongxia.Advances in molecular mechanisms of biliary atresia and hepatic fibrosis[J].Journal of Clinical Pediatric Surgery,2019,18(05):432-436.[doi:10.3969/j.issn.1671-6353.2019.05.019]
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胆道闭锁发生与肝纤维化的分子机制研究进展

参考文献/References:

1 陈小爱,杨继鑫,冯杰雄.胆道闭锁病因及其发病机制研究进展[J].中华实用儿科临床杂志,2015,30(19):1516-1518.DOI:10.3760/cma.j.issn.2095-428X.2015.19.021.Chen XA,Yang JX,Feng JX.Recent advances of etiology and mechanism of biliary atresia[J].Chin J Appl Clin pediatr,2015,30(19):1516-1518.DOI:10.3760/cma.j.issn.2095-428X.2015.19.021.
2 孟庆娅,詹江华.胆道闭锁病因学研究进展[J].天津医药,2008,36(10):826-827.DOI:10.3969/j.issn.0253-9896.2008.10.033.Meng QY,Zhan JH.Progress in etiology of biliary atresia[J].Tianjin Med J,2008,36(10):826-827.DOI:10.3969/j.issn.0253-9896.2008.10.033.
3 Keplinger KM,Bloomston M.Anatomy and embryology of the biliary tract[J].Surg Clin North Am,2014,94(2):203-217.DOI:10.1016/j.suc.2014.01.001
4 Mukhopadhyay SG,Roy P,Chatterjee U,et al.A histopathological study of liver and biliary remnants in the long-term survivors (>10 years) of cases of biliary atresia[J].Indian J Pathol Microbiol,2014,57(3):380-385.DOI:10.4103/0377-4929.138722.
5 冯杰雄,郑珊.小儿外科学[M].北京:人民卫生出版社,2014:125-128.Feng JX,Zheng S.Pediatric Surgery[M].Beijing:People’s Medical Publishing House,2014:125-128.
6 林海伟,李龙,刁美,等.胆道闭锁Kasai术后近中期疗效及部分影响因素分析[J].中华小儿外科杂志,2013,34(5):388-390.DOI:10.3760/cma.j.issn.0253-3006.2012.01.005.Lin HW,Li L,Diao M,et al.Impact of age at Kasai operation on short/mid-term outcomes of biliary atresia at a single institution[J].Chin J Pediatr Surg,2013,34(5):388-390.DOI:10.3760/cma.j.issn.0253-3006.2012.01.005.
7 Nakamura K,TanoueA.Etiology of biliary atresia as a developmental anomaly recent advances[J].J Hepatobiliary Pancreat Sci,2013,20(5):459-464.DOI:10.1007/s00534-013-0604-4.
8 金祝.胆道闭锁的基因研究进展[J].中华小儿外科杂志,2015,36(8):634-637.DOI:10.3760/cma.j.issn.0253-3006.2015.08.019.Jin Z.Advances in gene research of biliary atresia[J].Chin J Pediatr Surg,2015,36 (8):634-637.DOI:10.3760/cma.j.issn.0253-3006.2015.08.019.
9 Bezerra JA,Tiao G,Ryckman FC,et al.Genetic induction of proinflammatory immunity in children with biliary atresia[J].Lancet,2002,360(9346):1653-1659.DOI:10.1016/s0140-6736(02)11603-5.
10 Shinkai M,Shinkai T,Puri P,et al.Increased CXCR3 expression associated with CD3-positively lmphocytes in the liver and biliary Remnantin biliary atresia[J].J Pediatr Surg,2006,41(5):950-954.DOI:10.1016/j.j ped surg.2006.01.060.
11 Kong YY,Zhao JQ,Wang J,et al.Modified stool color card with digital images was efficient and feasible for early detection of biliary atresia-a pilot study in Beijing,China[J].World Journal of Pediatrics,2016,12(4):415-420.DOI:10.1007/s12519-016-0061-7.
12 Mack CL,Tucker RM,Sokol RJ,et al.Biliarya tresia is associated with CD4+Thl cell-mediated portal tract inflammation[J].PediatrRes,2004,56(1):79-87.DOI:10.1203/01.PDR.0000130480.51066.FB.
13 Takagi K,Yagi T,Shinoura S,et al.Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation[J].Acta Medica Okayama,2017,71(1):85-89.DOI:10.18926/AMO/54830.
14 Mack CL,Tucker RM,Sokol,et al.Armed CD4+Thl effector cells and activated macrophages participate in bite duct injury in murine biliary atresia[J].Clin Immunol,2005,15(2):200-209.
15 Mack CL,Tucker RM,Lu BR,et al.Cellular and humoral autoimmunit V djrected at bite duct epithelie in murme biliary atresia[J].HepatoIogy,2006,44(5):1231-1239.
16 Brindley SM,Lanham AM,Karrer FM,et al.Cyt Omegal Ovirus-specificT-cell reactivit V in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells[J] Hepato Iogy,2012,55(4):1130-1138.
17 Coots A,Donnelly B,Mohanty SK,et al.Rotavirus infection of human cholangiocytes parallels the murine.
18 Saito T,Hishiki T,Terui K,et al.Toll-like receptor m RNA expression in liver tissue from patients with biliary atresia[J].J Pediatr Gastroenterol Nutr,2011,53(6):620-626.
19 Huang YH,Chou MH,Du YY,et al.Expression of tollIike receptors and type 1 interferon specific protein MxA in biliary atresia[J].Lab Invest,2007,87(1):66-74.
20 陈功,郑珊.新生儿胆道闭锁治疗过程中的常见临床问题[J].临床肝胆病杂志,2015,31(8):1226-1229.DOI:10.3969/j.issn.1001-5256.2015.08.011.Chen G,Zheng S.Common clinical problems during treatment of neonatal biliary atresia[J].J Clin Hepa-tol,2015,31(8):1226-1229.DOI:10.3969/j.issn.1001-5256.2015.08.011.
21 Harada K,Sato Y,Isse K,et al.Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia[J].Liver Int,2008,28(5):614-621.
22 Feldman AG,Tucker RM,Tenner EK,et al.B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia[J].Plo S One,2013,8(8):663-644.
23 朱晓敏.小儿胆道闭锁肝组织MMP-1、MMP-2、内毒素和CD14的表达研究[D].苏州大学,2013.Zhu XM.Expression of MMP-1,MMP-2,endotoxin and CD14 in biliary atresia in children[D].Suzhou Universi-ty,2013.
24 杨瑛,汤绍涛,刘勇军.调节性T细胞、Th17和树突状细胞在胆道闭锁患儿免疫致病机制中的作用[J].中华小儿外科杂志2011,3(10):731-736.DOI:10.3760/cma.j.issn.0253-3006.2011.10.004.Yang Y,Tang ST,Liu YJ,et al.Role of regulation T cells,effect or Th17 and dendritic cells in the progressive inflammatory of biliary atresia[J].Chin J Pediatr Surg,2011,3(10):731-736.DOI:10.3760/cma.j.issn.0253-3006.2011.10.004.
25 王江,郑珊.胆道闭锁免疫失调机制的研究进展[J].中华实用儿科临床杂志,2014,29(17):1342-1345.DOI:10.3760/cma.j.issn.2095-428X.2014.17.016.Wang J,Zheng S.Advances of immunologic dysregulation mechanism in biliary atresia[J].J Chin J Appl Clin pediatr,2014,29(17):1342-1345.DOI:10.3760/cma.j.issn.2095-428X.2014.17.016.
26 彭飞,段栩飞.胆道闭锁发病机制研究进展.[J].临床小儿外科杂志2015,14(1):62-64.DOI:10.3969/j.issn,171-6353,2015.01.018.Peng F,Duan XF.Research advances on the pathogenesis of congenital biliary atresia[J] Clin Ped Sur,2015,14(1):62-64.DOI:10.3969/j.issn,171-6353,2015.01.018.
27 Muraj LT,Mate.Maimicro chimerism in biliary atresia:are maternal cells effector cells,targets or just bystanders[J].Chimerlsm,2014,5(1):1-5.
28 Taylor AW,Kitaichi N.The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy.Brain Behav Immun,2008,22(7):639-646.
29 Murata,K Kamata,Y Munakata,H Sugai,M Sasaki,M.Hepato-gastroenterology,2008,55(81):179-183.
30 王玮,郑珊,沈淳,等.新生儿巨细胞病毒感染与胆道闭锁肝脏纤维化的相关研究[J].中华小儿外科杂志,2005,26(9):464-466.Wang W,Zheng S,Shen C,et al.Relationship between infection of cytomegalovirns and liver fibrosis in biliary atresia[J].Chin J Pediatr Surg,2005,26(9):464-466.
31 Yong T,Xiao J,Wang YW,Chen KJ,Zhou J,Wen Y,Wang Y,Zhou WH,Pan W,Cai Cellular signaling,2014,26(5):925-932.
32 Shivakumar P,Mourya R,Bezerra JA.Perforin and granzy-mes work in synergy to mediate cholangiocyte injury in experimental biliary atresia[J].J Hepatol,2014,60(2):370-376.
33 Banales JM,Masyuk TV,Gradilone SA,et al.The c AMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).Hepatology,2009,49(2):160-174.
34 Caspary T,Larkins CE,Anderson KV.Graded response to Sonic Hedgehog depends on cilia architecture.Dev Cell,2007,12(10):767-778.
35 Kobayashi H,Horikoshi K,Yamataka A,et al.Are stable postoperative biliary atresia patients really stable[J].Pediat SURG LNT.2001.17(2):104-107.
36 Overall CM,Wrana JL,Sodek J.Transeriptional and posttranseriptional regulation 72-KDa gelatinase/type IV collagenase by transforming growth factor-betal in human fibroblasts:comparisons with collagenase and issue inhibitor of matrix metalloproteinase gene expression[M].J Biol chem,1991,266(11):14064-14071.
37 毛永忠,汤绍涛,阮庆兰.胆道闭锁肝脏组织MMP-2、TGF-β1的表达及意义[J].临床小儿外科杂志2007,6(3):6-9.Mao YZ,Tang ST,Ruan QL,et al.Expressions of MMP-2 and TGF-β1 in liver of biliary atresia and their relations with hepatic fibrosis[J].Clin Ped Sur,2007,17(3):6-9.
38 明安晓,王海斌,林海伟,等.胆道闭锁血清抗α-enolase 自身抗体检测及临床意义[J].中华小儿外科杂志,2012,33(4):263-267.DOI:10.3760/cma.J.issn.0253-3006.2012.04.006.Ming AX,Wang HB,Ling HW,et al.Examination of α-enolase autoantibodies in patients with bilialy atresia[J].Chin J Pediatr Surg,2012,33(4):263-267.DOI:10.3760/cma.J.issn.0253-3006.2012.04.006.
39 Markovics JAl,Araya J,Cambier S.Showing results for increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta through altering chromatin architecture[J].J Biol Chem.2011 Oct 21,286(42):64-74.
40 Omenetti A,Diehl AM.Hedgehog signaling in cholangiocytes.Curr Opin Gastroenterol,2011,27:268-275.
41 Chou MH,Chuang JH,Eng HL,et al.Endotoxin and CD14 in the progression of biliary atresia[J].J Transl Med,2010,8(2):138.
42 方燕彬,李索林,徐伟立,等.先天性胆道闭锁发病机制的研究进展[J].中华肝胆外科杂志,2014,20(8):612-616.DOI:10.3760/cma.j.issn.1007-8118.2014.08.01.Fang YB,Li SL,Xu WL,et al.Research advances in the pathogenesis of congenital biliary atresia[J].Chin J Hepatobiliary Surg,2014,20(8):612-616.DOI:10.3760/cma.j.issn.1007-8118.2014.08.01.

备注/Memo

收稿日期:2017-12-02。
通讯作者:任红霞,Email:renhongxia100@sina.com

更新日期/Last Update: 1900-01-01