Shi Chengren.Re-discussion on prevention and treatment of congenital megacolon enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):348-351.[doi:10.3969/j.issn.1671-6353.2019.05.002]
再谈先天性巨结肠小肠结肠炎的防治
- Title:
- Re-discussion on prevention and treatment of congenital megacolon enterocolitis
- Keywords:
- Hirschsprung Disease/CO; Enterocolitis; Necrotizing/ET; Enterocolitis; Necrotizing/PC; Enterocolitis; Necrotizing/TH
- 分类号:
- R722.1;R574.62
- 摘要:
- 小肠结肠炎（Hirschsprung’s disease associated enterocolitis，HAEC）是先天性巨结肠较为严重的一种合并症，其临床表现的轻重程度不一，轻者仅出现轻度腹胀，严重者则可发生严重感染性休克伴多脏器衰竭。本文将围绕近年来HAEC的治疗方案和病因学领域取得的研究进展做一评述，为进一步规范HAEC的诊治流程提供参考依据。
- Abstract:
- Hirschsprung’s disease associated enterocolitis (HAEC) is a serious complication of congenital megacolon.Its clinical manifestations vary in severity.Milder cases only have slight bloating and severe cases may be fatal septic shock with multiple organ failure.This article focuses upon recent research advances in the treatment and etiology of HAEC and provide rationales for further standardizing the diagnosis and treatment of HAEC.
参考文献/References:
1 Shen DH,Shi CR.Detection of intestinal bifidobacteria and lactobacilli in patients with Hirschsprung’s disease associated enterocolitis[J].World J Pediatr,2009,5(3):201-205.
2 沈涤华,施诚仁,周莹,等.肥大细胞检测在先天性巨结肠小肠结肠炎中的临床意义[J].中华小儿外科杂志,2008,29(2):85-87.DOI:10.3760/cma.j.issn.0253-3006.2008.02.007.Shen DH,Shi CR,Zhou Y,et al.Clinical significance of mast cell detection in congenital megacolon enterocolitis[J].Chinese Journal of Pediatric Surgery,2008,29(2):85-87.DOI:10.3760/cma.j.issn.0253-3006.2008.02.007.
3 Zhou Y,Shi CR,Liu W,et al.The preliminary study on fabrication tissue engineered intestine of rat with intestinal epithelial organic units seeded into cylinder polymer scaffold[J].Tissue Engineering,2006,12(4):1122.
4 虞贤贤,施诚仁,蔡威.先天性巨结肠小肠结肠炎发病机制及防治研究进展[J].临床小儿外科杂志,2018,17(4):61-66.DOI:10.3969/j.issn.1671-6353.2018.04.013.Yu XX,Shi CR,Cai W.Progress in the pathogenesis and prevention of congenital megacolon enterocolitis[J].J Clin Ped Sur,2018,17(4):61-66.DOI:10.3969/j.issn.1671-6353.2018.04.013.
5 Austin KM.The pathogenesis of Hirschsprung’s disease-associated enterocolitis[J].Seminars in Pediatric Surgery,2012,21(4):319-327.DOI:10.1053/j.sempedsurg.2012.07.006.
6 Menezes M,Corbally M,Puri P.Long-term results of bowel function after treatment for Hirschsprung’s disease:a 29-year review[J].Pediatric Surgery International,2006,22(12):987-990.DOI:10.1007/s00383-006-1783-8.
7 Gosain A,Frykman PK,Cowles RA,et al.Guidelines for the diagnosis and management of Hirschsprung-associated enterocolitis[J].Pediatric Surgery International,2017,33(5):517-521.DOI:10.1007/s00383-017-4065-8.
8 Pastor AC,Osman F,Teitelbaum DH,et al.Development of a standardized definition for Hirschsprung’s-associated enterocolitis:a Delphi analysis[J].Journal of Pediatric Surgery,2009,44(1):250-256.DOI:10.1016/j.jpedsurg.2008.10.052.
9 Frykman PK,Kim S,Wester T,et al.Critical evaluation of the Hirschsprung-associated enterocolitis (HAEC) score:A multicenter study of 116 children with Hirschsprung disease[J].Journal of Pediatric Surgery,2017:S0022346817304219.DOI:10.1016/j.jpedsurg.2017.07.009.
10 Frykman PK,Kim S,Wester T,et al.Critical evaluation of the Hirschsprung-associated enterocolitis (HAEC) score:A multicenter study of 116 children with Hirschsprung disease[J].Journal of Pediatric Surgery,2017:S0022346817304219.DOI:10.1016/j.jpedsurg.2017.07.009.
11 Langer JC,Rollins MD,Levitt M,et al.Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease[J].Pediatric Surgery International,2017,33(5):523-526.DOI:10.1007/s00383-017-4066-7.
12 Maciak A,Vucurevic G,Kronfeld A,et al.Complex fluid collection on abdominal ultrasound indicates need for surgery in neonates with necrotizing enterocolitis[J].European Journal of Pediatric Surgery,2017,27(2):161-165.DOI:10.1055/s-0036-1580702.
13 Hackam DJ,Filler RM,Pearl RH.Enterocolitis after the surgical treatment of Hirschsprung’s disease:Risk factors and financial impact[J].Journal of Pediatric Surgery,1998,33(6):830-833.DOI:10.1016/S0022-3468(98)90652-2.
14 Li B,Lee C,Cadete M,et al.Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders[J].Pediatric Surgery International,2018,23(1):1-5.DOI:10.1007/s00383-018-4369-3.
15 Cronberg SL,Anne S,Kjaer TW,et al.Quantitative electroencephalography as a diagnostic tool for Alzheimer’s dementia in adults with Down syndrome[J].Dementia & Geriatric Cognitive Disorders Extra,2015,5(3):404-413.DOI:10.1159/000438857.
16 Spahis JK,Wilson GN.Down syndrome:Perinatal complications and counseling experiences in 216 patients[J].American Journal of Medical Genetics,1999,89(2):96-99.
17 Wallace,Robyn A.Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic[J].Journal of Intellectual and Developmental Disability,2007,32(1):45-50.DOI:10.1080/13668250601146761.
18 Kallén,Bengt,Mastroiacovo P,Robert E.Major congenital malformations in Down syndrome[J].American Journal of Medical Genetics,1996,65(2):160-166.
19 Moore SW.Hirschsprung’s disease and the brain[J].Pediatric Surgery International,2011,27(4):347-352.DOI:10.1007/s00383-010-2807-y.
20 Friedmacher F,Puri P.Hirschsprung’s disease associated with Down syndrome:a meta-analysis of incidence,functional outcomes and mortality[J].Pediatric Surgery International,2013,29(9):937-946.DOI:10.1007/s00383-013-3361-1.
21 Heuckeroth RO,Schafer KH.Gene-environment interactions and the enteric nervous system:Neural plasticity and Hirschsprung disease prevention[J].Developmental Biology,2016:S0012160616300033.DOI:10.1016/j.ydbio.2016.03.017.
22 Nakazato Y,Landing BH.Reduced Number of Neurons in Esophageal Plexus Ganglia in Down Syndrome:Additional evidence for reduced cell number as a basic feature of the disorder[J].Fetal & Pediatric Pathology,1986,5(1):55-63.DOI:10.3109/15513818609068848.
23 Kyrklund K,Neuvonen MI,Pakarinen MP,et al.Social morbidity in relation to bowel functional outcomes and quality of life in anorectal malformations and Hirschsprung’s disease[J].European Journal of Pediatric Surgery,28(6):522-528.DOI:10.1055/s-0037-1607356.
24 Nishikawa R,Hotta R,Shimojima N,et al.Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease[J].Cytotechnology,2015,67(4):661-670.DOI:10.1007/s10616-014-9754-8.
25 Anne marie O’Donnell,Hiroki Nakamara,Chiristian Tomuschat.Abnormal scnlb and Fxyd 1 gene expression in the pulled-through ganglionic colon may influence functional outcome in patients with Hirschsprung’s disease[J].Pediatr Surg Int,2019,35(1):9-14.DOI:10.1007/s00383-018-4370-x.
26 Rintala R.Sodium cromoglycate in the management of chronic or recurrent enterocolitis in patients with Hirschsprung’s disease[J].J Pediatr Surg,2001,36(7):1032-1035.DOI:10.1053/jpsu.2001.24732.
相似文献/References:
[1]侯龙龙 李仲荣 黄璜. 新生儿坏死性小肠结肠炎预后相关因素分析[J].临床小儿外科杂志,2014,13(05):396.
[2]史婧奕,吕志宝.. 双歧杆菌三联活菌散预防早产儿坏死性小肠结肠炎的临床初探[J].临床小儿外科杂志,2016,15(01):72.
[3]潘登,王献良,邵雷朋..新生儿坏死性小肠结肠炎经回肠造瘘术后远端肠闭锁7例[J].临床小儿外科杂志,2016,15(05):513.
[4]臧婧羽,袁小建,程思旸,等.单中心不同手术方式治疗全结肠型巨结肠疗效分析[J].临床小儿外科杂志,2018,17(02):106.
Zang Jingyu,Yuan Xiaojian,Cheng Siyang,et al.The efficacy analysis of different operative methods in treating Total Colonic Aganglionosis (TCA) in a Single Center.[J].Journal of Clinical Pediatric Surgery,2018,17(05):106.
[5]吴书清,钟斌,刘辉,等. Bishop-Koop 造瘘术和双口造瘘术在新生儿坏死性小肠结肠炎中的疗效比较[J].临床小儿外科杂志,2018,17(11):835.
Wu Shuqing,Zhong Bin,Liu Hui,et al. Comparison of therapeutic efficacies of BishopKoop stoma versus double mouth enterostomy for neonatal necrotizing enterocolitis.[J].Journal of Clinical Pediatric Surgery,2018,17(05):835.
[6]吕志宝,盛庆丰.新生儿坏死性小肠炎的病因与诊治研究进展[J].临床小儿外科杂志,2019,18(05):352.[doi:10.3969/j.issn.1671-6353.2019.05.003]
Lv Zhibao,Sheng Qingfeng.Advances in the etiology, diagnosis and treatment of neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):352.[doi:10.3969/j.issn.1671-6353.2019.05.003]
[7]安宗剑,孙勇.新生儿肠道菌群与坏死性小肠结肠炎发病关系的研究进展[J].临床小儿外科杂志,2019,18(05):356.[doi:10.3969/j.issn.1671-6353.2019.05.004]
An Zongjian,Sun Yong.Research advances of neonatal intestinal microbiome and necrotising enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):356.[doi:10.3969/j.issn.1671-6353.2019.05.004]
[8]郑泽兵,刘远梅,张帆,等.降钙素原、白细胞介素6、C反应蛋白在新生儿坏死性小肠结肠炎手术时机选择中的应用价值研究[J].临床小儿外科杂志,2019,18(05):361.[doi:10.3969/j.issn.1671-6353.2019.05.005]
Zheng Zebing,Liu Yuanmei,Zhang Fan,et al.Applicable value of operative opportunity for procalcitonin, interleukin-6 and C-reactive protein in neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):361.[doi:10.3969/j.issn.1671-6353.2019.05.005]
[9]杜京斌,陈永卫,郭卫红,等.新生儿坏死性小肠结肠炎手术干预指征的回顾性研究[J].临床小儿外科杂志,2019,18(05):368.[doi:10.3969/j.issn.1671-6353.2019.05.006]
Du Jingbin,Chen Yongwei,Guo Weihong,et al.Retrospectivestudy of indications for surgical intervention inneonatal necrotizingenterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):368.[doi:10.3969/j.issn.1671-6353.2019.05.006]
[10]梁琼鹤,蒋维维,路长贵,等.新生儿肠道手术后并发坏死性小肠结肠炎的临床特征分析[J].临床小儿外科杂志,2019,18(05):372.[doi:10.3969/j.issn.1671-6353.2019.05.007]
Liang Qionghe,Jiang Weiwei,Lu Changgui,et al.Clinical characteristics of Necrotizing enterocolitis after neonatal intestinal surgery[J].Journal of Clinical Pediatric Surgery,2019,18(05):372.[doi:10.3969/j.issn.1671-6353.2019.05.007]
备注/Memo
收稿日期:2019-04-18。
作者简介:施诚仁,Email:shicr629@163.com