Lv Zhibao,Sheng Qingfeng.Advances in the etiology, diagnosis and treatment of neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):352-355.[doi:10.3969/j.issn.1671-6353.2019.05.003]
新生儿坏死性小肠炎的病因与诊治研究进展
- Title:
- Advances in the etiology, diagnosis and treatment of neonatal necrotizing enterocolitis
- Keywords:
- Enterocolitis; Necrotizing/ET; Enterocolitis; Necrotizing/PC; Enterocolitis; Necrotizing/TH; Genomics; Infant; Newborn
- 分类号:
- R722.1;R393
- 摘要:
- 新生儿坏死性小肠结肠炎是导致早产儿和低出生体重儿死亡的重要原因之一，该病的早期识别及严重程度的判断较为困难。随着分子医学研究的进展，采用组学数据分析技术等新的研究手段可以更全面、精准地研究NEC的发病机制，寻找更为理想的生物标志物。此外，单独应用某个指标常常很难在疾病早期准确预测肠坏死，而多种指标联合应用有助于更准确地把握手术时机。另外，采取母乳喂养等多种预防措施可有效降低NEC的发病率。本文旨在针对新生儿坏死性小肠结构肠炎的前期预防策略及分子医学研究进展进行浅谈。
- Abstract:
- Necrotizing enterocolitis (NEC) is a leading cause of death from gastrointestinal disease in premature and low-birth-weight infants.Early detection of severely ischemic or necrotic bowel before perforation is rather difficult.New techniques including multi-omics contribute to better understanding its underlying mechanisms and discovering different categories of biomarkers.Combination of clinical metrics such as seven components of metabolic derangement (CMD) may provide accurate assessment of its severity.Implementation of quality improvement initiatives including breast milk feeding actually lowers its incidence.
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备注/Memo
收稿日期:2019-02-23。
基金项目:国家自然科学基金资助项目（编号：81871194，81601322）
通讯作者:吕志宝,Email:lvzhibao@sohu.com