Ou Wenhui,Xiao Wenfeng,Xie Xinquan,et al.Relationship between INSL3-RXFP2 and reproductive system[J].Journal of Clinical Pediatric Surgery,2023,22(02):192-196.[doi:10.3760/cma.j.cn101785-202010031-018]
INSL3-RXFP2与两性生殖系统关系研究进展
- Title:
- Relationship between INSL3-RXFP2 and reproductive system
- Keywords:
- Insulin-like Factor 3; Relaxin Family Peptide Receptor 2; Cryptorchidism; Male Reproductive System; Female Reproductive System
- 摘要:
- 胰岛素样因子3(insulin-like factor 3,INSL3)在两性生殖系统中均有表达,在雄性个体中主要由睾丸间质细胞分泌,在雌性个体中主要由卵泡膜分泌。INSL3的受体为松弛素家族受体2(relaxin family peptide receptor 2,RXFP2),在雄性生殖系统中主要表达于引带细胞、生殖细胞以及睾丸间质细胞,在雌性生殖系统中主要表达于卵细胞及卵泡膜细胞。INSL3-RXFP2通路作用于两性生殖系统,其通路异常与两性生殖系统疾病密切相关。本文将结合最新研究进展,对INSL3-RXFP2与两性生殖系统的关系进行综述。
- Abstract:
- Insulin-like factor 3(INSL3)is predominantly secreted by Leydig’s cell in males and theca cells in females.Its specific receptor,relaxin family peptide receptor 2(RXFP2),is expressed in gubernacular,germ and Leydig’s cells.RXFP2 is also expressed in ovary and theca cells.Abnormity of INSL3-RXFP2 complex is related to reproductive disease in both males and females.This review summarized the latest researches about the relationship between INSL3-RXFP2 complex and reproductive system.
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备注/Memo
收稿日期:2020-10-21。
基金项目:国家自然科学基金青年项目(81801432);广东省自然科学基金(2022A1515010407、2020A1515010135、2018A030307045);广东省科技专项资金("大专项+任务清单")(STKJ2021119); 汕头市医疗卫生科技计划项目(汕府科【2020】58-35)
通讯作者:李建宏,Email:jianhongli2013@163.com