Wei Yuanyuan,Fan Jinnan,Li Yarui.Meta-analysis of the relationship between single nucleotide polymorphism of rs17095355 and biliary atresia[J].Journal of Clinical Pediatric Surgery,2020,19(06):496-502.[doi:10.3969/j.issn.1671-6353.2020.06.007]
ADD3基因rs17095355位点多态性与胆道闭锁相关性研究的Meta分析
- Title:
- Meta-analysis of the relationship between single nucleotide polymorphism of rs17095355 and biliary atresia
- Keywords:
- Biliary Atresia/ET; Meta-Analysis; Genes
- 分类号:
- R722;R575.7;R725.7
- 摘要:
- 目的 采用Meta分析方法对rs17095355位点多态性与胆道闭锁相关性进行分析。方法 纳入文献的发表时间截至2019年7月，检索英文数据库（PubMed、EMbase、Web of Science）及中文数据库（中国知网、万方数据知识服务平台、维普期刊资源整合服务平台和中国生物医学文献服务系统）中rs17095355位点基因多态性与胆道闭锁相关性的文献。采用Stata 14.0软件进行Meta分析。结果 最终纳入7篇文献，共纳入8组独立样本的研究，共纳入6 397人。Meta分析显示，rs17095355位点多态性与胆道闭锁患病风险相关，在等位基因、隐性基因、显性基因遗传模型下合并OR值及其95%CI分别为1.66（1.44~1.90）、1.66（1.38~2.01）和2.16（1.38~3.37），差异有统计学意义（P<0.05）。亚洲人群中等位基因遗传模型下该位点与胆道闭锁患病风险的合并OR值及其95％CI为1.72（1.48~1.99），差异有统计学意义（P<0.05）。按样本量大小进行亚组分析后，异质性减少。结论 rs17095355位点多态性与胆道闭锁患病风险有关，特别是在亚洲人群中，T等位基因可能是发生胆道闭锁的危险因素，但该结论仍需不同种族中更多高质量、大样本的研究进一步证实。
- Abstract:
- Objective To systematically evaluate the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and biliary atresia (BA).Methods The literature retrieval was conducted by searching the English databases (PubMed,EMbase & Web of Science) and Chinese databases (CNKI,Wanfang,VIP & SinoMed) for the publications on the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and BA by late July 2019.Meta-analysis was performed with software Stata 14.0.Results Seven reports and 8 independent studies were retrieved.Significant associations existed between higher risk of BA and single nucleotide polymorphism of rs17095355.The combined OR were 1.66(1.44-1.90) in allele,1.66(1.38-2.01) in dominant and 2.16(1.38-3.37) in recessive genetic model respectively (all P<0.05).The combined OR in allele genetic model was 1.72(1.48-1.99) in Asian populations (P<0.05).Sample size subgroup analysis showed lower heterogeneity.Conclusion There is significant association between BA and single nucleotide polymorphism of rs17095355,especially in Asian populations.T allele is a high-risk gene for BA.The results should be confirmed by larger high-quality samples from different ethnic groups.
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备注/Memo
收稿日期:2019-07-26。
基金项目:山西医科大学省级博士基金项目（编号：SD1828）
通讯作者:李亚蕊,Email:zyl3212008@sina.com