Zhou Enqing,Dong Rui.Research advances of berberine in pediatric embryonal tumors[J].Journal of Clinical Pediatric Surgery,2023,22(12):1135-1138.[doi:10.3760/cma.j.cn101785-202208042-008]
黄连素在儿童胚胎源性肿瘤中的研究进展
- Title:
- Research advances of berberine in pediatric embryonal tumors
- Keywords:
- Berberine; Embryonal Tumors; Neuroblastoma; Hepatoblastoma; Nephroblastoma; Child
- 摘要:
- 黄连素又名小檗碱,是一种苯基四异喹啉生物碱,可从黄连等多种植物中提取,也是黄连解毒汤、左金丸等多种中药方剂的主要成分。黄连素已被证实对微生物感染、炎症、心血管疾病、胃肠疾病、神经退行性疾病、抑郁症、代谢功能障碍等疾病具有多种有益的生物活性。黄连素可通过不同机制抑制食管癌、结肠腺癌、肝癌、骨肉瘤、乳腺癌等多种肿瘤细胞的增殖,促进凋亡;并被发现可以作用于多种儿童胚胎源性肿瘤细胞,如神经母细胞瘤、肝母细胞瘤、横纹肌肉瘤等。本文通过文献复习,阐述黄连素在儿童胚胎源性肿瘤中的药物作用,以期对后续黄连素用于胚胎源性肿瘤的研究有所帮助。
- Abstract:
- Huangliansu,also known as berberine,is abenzyl tetra isoquinoline alkaloid.Extracted from Coptis chinensis and other plants,it is also a major ingredient of Huanglian Jiedu Decoction,Zuojin Pills and other traditional Chinese medicine prescriptions.It has proved to have a variety of beneficial biological activities for treating infection,inflammation,cardiovascular diseases,gastrointestinal diseases,neurodegeneration,depression and metabolic disorders.Furthermore,it inhibits the proliferation and promotes apoptosis of esophageal cancer,colonic adenocarcinoma,liver cancer,osteosarcoma,breast cancer and other tumor cells through different mechanisms.Also it may act on a variety of cells of pediatric embryonal tumors,such as neuroblastoma,hepatoblastoma and rhabdomyosarcoma.Thus it is a potential antineoplastic drug.Through a literature review,the authors summarized the drug effects of berberine in embryonal tumors to provide references for follow-up studies.
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备注/Memo
收稿日期:2022-8-24。
通讯作者:董瑞,Email:rdong@fudan.edu.cn