Xu Chencheng,Jiang Dapeng.Fertility preservation in pediatric and adolescent cancer patients: clinical and ethical considerations[J].Journal of Clinical Pediatric Surgery,2023,22(09):892-895.[doi:10.3760/cma.j.cn101785-202208013-018]
儿童/青少年癌症患者生育力保护的临床咨询及相关伦理问题
- Title:
- Fertility preservation in pediatric and adolescent cancer patients: clinical and ethical considerations
- Keywords:
- Fertility Preservation; Cancer; Ethical Consideration
- 摘要:
- 许多发生于儿童和青少年的癌症都可通过手术、化疗或放疗治愈,外科手术摘除生殖器官或肿瘤放化疗的毒副作用可能导致患者生育力受损。近年来,辅助生殖技术的发展为预防和治疗生育力受损提供了新的可能。本文旨在综述儿童/青少年癌症患者生育力保护中的临床咨询及相关伦理问题。
- Abstract:
- Most cancers occurring in children and adolescents may be cured by surgery,chemotherapy or radiotherapy.Fertility is probably impaired due to a removal of reproductive organs or toxic/side effects of anti-cancer radiochemotherapy.In recent years,emerging assisted reproductive technologies offer new possibilities for managing impaired fertility.This review summarized the related medical issues and ethical considerations for fertility preservation in pediatric and adolescent cancer patients.
参考文献/References:
[1] Skinner R,Mulder RL,Kremer LC,et al.Recommendations for gonadotoxicity surveillance in male childhood,adolescent,and young adult cancer survivors:a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium[J].Lancet Oncol,2017,18(2):e75-e90.DOI:10.1016/S1470-2045(17)30026-8.
[2] Chow EJ,Stratton KL,Leisenring WM,et al.Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999:a report from the Childhood Cancer Survivor Study cohort[J].Lancet Oncol,2016,17(5):567-576.DOI:10.1016/S1470-2045(16)00086-3.
[3] Green DM,Liu W,Kutteh WH,et al.Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer:a report from the St Jude Lifetime Cohort Study[J].Lancet Oncol,2014,15(11):1215-1223.DOI:10.1016/S1470-2045(14)70408-5.
[4] van Dorp W,Haupt R,Anderson RA,et al.Reproductive function and outcomes in female survivors of childhood,adolescent,and young adult cancer:a review[J].J Clin Oncol,2018,36(21):2169-2180.DOI:10.1200/JCO.2017.76.3441.
[5] Hussein RS,Khan Z,Zhao YL.Fertility preservation in women:indications and options for therapy[J].Mayo Clin Proc,2020,95(4):770-783.DOI:10.1016/j.mayocp.2019.10.009.
[6] Sayan M,Cassidy RJ,Butker EE,et al.Gonadal shielding technique to preserve fertility in male pediatric patients treated with total body irradiation for stem cell transplantation[J].Bone Marrow Transplant,2016,51(7):997-998.DOI:10.1038/bmt.2016.25.
[7] Pietzak EJ 3rd,Tasian GE,Tasian SK,et al.Histology of testicular biopsies obtained for experimental fertility preservation protocol in boys with cancer[J].J Urol,2015,194(5):1420-1424.DOI:10.1016/j.juro.2015.04.117.
[8] Whelan EC,Yang F,Avarbock MR,et al.Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity[J].PLoS Biol,2022,20(5):e3001618.DOI:10.1371/journal.pbio.3001618.
[9] Fernandez-Pineda I,Davidoff AM,Lu L,et al.Impact of ovarian transposition before pelvic irradiation on ovarian function among long-term survivors of childhood Hodgkin lymphoma:A report from the St.Jude Lifetime Cohort Study[J].Pediatr Blood Cancer,2018,65(9):e27232.DOI:10.1002/pbc.27232.
[10] Aubard Y,Piver P,Pech JC,et al.Ovarian tissue cryopreservation and gynecologic oncology:a review[J].Eur J Obstet Gynecol Reprod Biol,2001,97(1):5-14.DOI:10.1016/s0301-2115(00)00479-6.
[11] Armstrong AG,Kimler BF,Smith BM,et al.Ovarian tissue cryopreservation in young females through the Oncofertility Consortium’s National Physicians Cooperative[J].Future Oncol,2018,14(4):363-378.DOI:10.2217/fon-2017-0410.
[12] Matthews SJ,Picton H,Ernst E,et al.Successful pregnancy in a woman previously suffering from β-thalassemia following transplantation of ovarian tissue cryopreserved before puberty[J].Minerva Ginecol,2018,70(4):432-435.DOI:10.23736/S0026-4784.18.04240-5.
[13] Stigliani S,Massarotti C,De Leo C,et al.Fifteen year regional center experience in sperm banking for cancer patients:use and reproductive outcomes in survivors[J].Cancers (Basel),2021,13(1):116.DOI:10.3390/cancers13010116.
[14] Cobo A,García-Velasco JA,Coello A,et al.Oocyte vitrification as an efficient option for elective fertility preservation[J].Fertil Steril,2016,105(3):755-764.e8.DOI:10.1016/j.fertnstert.2015.11.027.
[15] Oktay K,Harvey BE,Partridge AH,et al.Fertility preservation in patients with cancer:ASCO clinical practice guideline update[J].J Clin Oncol,2018,36(19):1994-2001.DOI:10.1200/JCO.2018.78.1914.
[16] Diesch T,Rovo A,von der Weid N,et al.Fertility preservation practices in pediatric and adolescent cancer patients undergoing HSCT in Europe:a population-based survey[J].Bone Marrow Transplant,2017,52(7):1022-1028.DOI:10.1038/bmt.2016.363.
[17] Panagiotopoulou N,van Delft FW,Hale JP,et al.Fertility preservation care for children and adolescents with cancer:an inquiry to quantify professionals’ barriers[J].J Adolesc Young Adult Oncol,2017,6(3):422-428.DOI:10.1089/jayao.2016.0087.
[18] Jayasuriya S,Peate M,Allingham C,et al.Satisfaction,disappointment and regret surrounding fertility preservation decisions in the paediatric and adolescent cancer population[J].J Assist Reprod Genet,2019,36(9):1805-1822.DOI:10.1007/s10815-019-01536-4.
[19] Skaczkowski G,White V,Thompson K,et al.Factors influencing the documentation of fertility-related discussions for adolescents and young adults with cancer[J].Eur J Oncol Nurs,2018,34:42-48.DOI:10.1016/j.ejon.2018.02.007.
[20] Gupta AA,Donen RM,Sung L,et al.Testicular biopsy for fertility preservation in prepubertal boys with cancer:identifying preferences for procedure and reactions to disclosure practices[J].J Urol,2016,196(1):219-224.DOI:10.1016/j.juro.2016.02.2967.
[21] Benedict C,Thom B,N Friedman D,et al.Young adult female cancer survivors’ unmet information needs and reproductive concerns contribute to decisional conflict regarding posttreatment fertility preservation[J].Cancer,2016,122(13):2101-2109.DOI:10.1002/cncr.29917.
[22] Affdal AO,Ravitsky V.The best interest standard and the child’s right to an open futureJ].Am J Bioeth,2018,18(8):74-76.DOI:10.1080/15265161.2018.1485769.
[23] Algarroba GN,Sanfilippo JS,Valli-Pulaski H.Female fertility preservation in the pediatric and adolescent cancer patient population[J].Best Pract Res Clin Obstet Gynaecol,2018,48:147-157.DOI:10.1016/j.bpobgyn.2017.10.009.
[24] Khalife D,Kutteh W,Tarhini H,et al.Parental attitudes toward fertility preservation in female adolescent cancer patients in Lebanon[J].J Pediatr Adolesc Gynecol,2019,32(5):525-529.DOI:10.1016/j.jpag.2019.05.006.
[25] Sisk BA,Canavera K,Sharma A,et al.Ethical issues in the care of adolescent and young adult oncology patients[J].Pediatr Blood Cancer,2019,66(5):e27608.DOI:10.1002/pbc.27608.
[26] Affdal AO,Ravitsky V.Parents’ posthumous use of daughter’s ovarian tissue:ethical dimensions[J].Bioethics,2019,33(1):82-90.DOI:10.1111/bioe.12491.
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备注/Memo
收稿日期:2022-8-5。
基金项目:市级医院诊疗技术推广及优化管理项目(SHDC22022306)
通讯作者:姜大朋,Email:jdp509@163.com