Li Nan,Wang Jianjun,Huang Zhaorong,et al.Infant hepatic hilar hemangioendothelioma plus Kasabach-Merritt syndrome causing biliary obstruction:one case report and literature review[J].Journal of Clinical Pediatric Surgery,2023,22(05):471-475.[doi:10.3760/cma.j.cn101785-202202001-013]
婴儿肝门部血管内皮瘤合并Kasabach-Merritt综合征引起胆道梗阻1例及文献复习
- Title:
- Infant hepatic hilar hemangioendothelioma plus Kasabach-Merritt syndrome causing biliary obstruction:one case report and literature review
- 关键词:
- Kasabach-Merritt综合征; 血管内皮瘤; 胆道疾病; 西罗莫司
- 摘要:
- Kasabach-Merritt综合征(Kasabach-Merritt Syndrome,KMS)以巨大血管瘤伴血小板减少和全身出血倾向为主要特征,肝血管瘤合并KMS临床较为罕见,迄今为止仅报道8例,巨大血管瘤位于肝门部的病例尚未见报道。本文报道南方医科大学珠江医院小儿外科收治的1例肝门部血管内皮瘤合并KMS,经西罗莫司治疗后出现胆道梗阻的患儿诊治经验,并对相关文献进行复习。
参考文献/References:
[1] Akiyoshi K,Mizote H,Tanaka Y,et al.Capillary hemangioma of the liver with Kasabach-Merritt syndrome in a neonate:report of a case[J].Surg Today,2000,30(1):86-88.DOI:10.1007/PL00010055.
[2] Billio A,Pescosta N,Rosanelli C,et al.Treatment of Kasabach-Merritt syndrome by embolisation of a giant liver hemangioma[J].Am J Hematol,2001,66(2):140-141.DOI:10.1002/1096-8652(200102)66:2<140::AID-AJH1031>3.0.CO;2-5.
[3] Shen WC,Liang PC,Wu JF,et al.Combined transarterial embolization and propranolol as effective treatment for hepatic hemangioma with Kasabach-Merritt syndrome and heart failure in a neonate[J].Pediatr Neonatol,2017,58(2):191-193.DOI:10.1016/j.pedneo.2016.01.008.
[4] Watanabe S,Manabe M,Miyata M,et al.A case of neonate effectively treated with everolimus for giant hepatic hemangioma complicated with congenital duodenal atresia and Kasabach-Merritt syndrome[J].J Neonatal Perinatal Med,2021,14(3):437-440.DOI:10.3233/NPM-200504.
[5] 王英豪,戴立英,王丽丽,等.16例新生儿卡梅综合征临床分析[J].中国当代儿科杂志,2021,23(7):696-701.DOI:10.7499/j.issn.1008-8830.2103146. Wang YH,Dai LY,Wang LL,et al.Clinical features of Kasabach-Merritt syndrome:a report of 16 neonates[J].Chin J Contemp Pediatr,2021,23(7):696-701.DOI:10.7499/j.issn.1008-8830.2103146.
[6] 李先红,张健,戴立英,等.5例新生儿婴儿型肝血管内皮瘤报道[J].重庆医学,2022,51(5):783-785,790.DOI:10.3969/j.issn.1671-8348.2022.05.013. Li XH,Zhang J,Dai LY,et al.Diagnosis and treatment of infantile hepatic hemangioendothelioma:a report of 5 cases[J].Chongqing Med,2022,51(5):783-785,790.DOI:10.3969/j.issn.1671-8348.2022.05.013.
[7] Selzer Soria EM,Malla I.Propranolol treatment in Kasabach-Merritt Syndrome secondary to congenital hepatic hemangioma:clinical case[J].Arch Argent Pediatr,2021,119(1):e65-e69.DOI:10.5546/aap.2021.e65.
[8] 吴凯,王健俊,何继贤,等.结肠系膜血管瘤合并Kasabach-Merritt综合征破裂伴失血性休克1例并文献复习[J].临床小儿外科杂志,2019,18(3):247-249.DOI:10.3969/j.issn.1671-6353.2019.03.018. Wu K,Wang JJ,He JX,et al.Rupture of mesenteric Kasabach-Merritt syndrome associated with hemorrhagic shock:one case report with a literature review[J].J Clin Ped Sur,2019,18(3):247-249.DOI:10.3969/j.issn.1671-6353.2019.03.018.
[9] Harmanci O,Bayraktar Y.How can portal vein cavernous transformation cause chronic incomplete biliary obstruction?[J].World J Gastroenterol,2012,18(26):3375-3378.DOI:10.3748/wjg.v18.i26.3375.
[10] 杨开颖,彭素华.婴幼儿肝血管瘤诊治现状[J].临床小儿外科杂志,2020,19(8):746-751.DOI:10.3969/j.issn.1671-6353.2020.08.016. Yang KY,Peng SH.Current status of diagnosing and treating infantile hepatic hemangioma[J].J Clin Ped Sur,2020,19(8):746-751.DOI:10.3969/j.issn.1671-6353.2020.08.016.
[11] O’Rafferty C,O’Regan GM,Irvine AD,et al.Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon[J].Br J Haematol,2015,171(1):38-51.DOI:10.1111/bjh.13557.
[12] Chen YJ,Wang CK,Tien YC,et al.MRI of multifocal kaposiform haemangioendothelioma without Kasabach-Merritt phenomenon[J].Br J Radiol,2009,82(975):e51-e54.DOI:10.1259/bjr/16482217.
[13] 齐鸿燕,马琳,张金哲.婴儿巨大血管瘤合并血小板减少综合征8例[J].临床小儿外科杂志,2008,7(6):47-48,50.DOI:10.3969/j.issn.1671-6353.2008.06.016. Qi HY,Ma L,Zhang JZ.Infantile giant hemangioma with thrombocytopenia syndrome:a report of 8 cases[J].J Clin Ped Sur,2008,7(6):47-48,50.DOI:10.3969/j.issn.1671-6353.2008.06.016.
[14] Peker E,K?r?m? E,Tuncer O,et al.Brachial plexus paralysis due to giant cavernous hemangioma with Kasabach-Merritt syndrome:successful management with interferon alpha[J].Platelets,2009,20(8):603-605.DOI:10.3109/09537100903247790.
[15] Wang P,Zhou W,Tao L,et al.Clinical analysis of Kasabach-Merritt syndrome in 17 neonates[J].BMC Pediatr,2014,14(1):146.DOI:10.1186/1471-2431-14-146.
[16] 张元元,张永红,罗洁,等.血管瘤伴血小板减少综合征11例[J].中国小儿血液与肿瘤杂志,2007,12(2):64-67.DOI:10.3969/j.issn.1673-5323.2007.02.005. Zhang YY,Zhang YH,Luo J,et al.Kasabach-Merritt syndrome:a report of 11 cases[J].J China Pediatr Blood Cancer,2007,12(2):64-67.DOI:10.3969/j.issn.1673-5323.2007.02.005.
[17] 中华医学会小儿外科学分会肝胆外科学组,中华医学会小儿外科学分会肿瘤学组.小儿肝血管瘤诊断和治疗专家共识[J].中华小儿外科杂志,2020,41(11):963-970.DOI:10.3760/cma.j.cn421158-20200228-00124. Group of Hepatobiliary Surgery,Branch of Pediatric Surgery; Group of Oncology,Branch of Pediatric Surgery,Chinese Medical Association.Expert Consensus on Diagnosing and Treating Hepatic Hemangioma in Children[J].Chin J Pediatr Surg,2020,41(11):963-970.DOI:10.3760/cma.j.cn421158-20200228-00124.
[18] 吴泽键,林四平,潘彧,等.雷帕霉素对普萘洛尔治疗无效的血管瘤患儿临床疗效分析[J].岭南现代临床外科,2018,18(4):383-385.DOI:10.3969/j.issn.1009-976X.2018.04.003. Wu ZJ,Lin SP,Pan Y,et al.Clinical efficacy of rapamycin for infantile hemangioma after failed propranolol treatment[J].Lingnan Mod Clin Surg,2018,18(4):383-385.DOI:10.3969/j.issn.1009-976X.2018.04.003.
[19] Cho YJ,Kwon H,Kwon YJ,et al.Effects of sirolimus in the treatment of unresectable infantile hemangioma and vascular malformations in children:a single-center experience[J].J Vasc Surg Venous Lymphat Disord,2021,9(6):1488-1494.DOI:10.1016/j.jvsv.2021.03.014.
[20] Wang Y,Kong LL,Sun BH,et al.Sirolimus for Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon in two infants[J].J Craniofac Surg,2020,31(4):1074-1077.DOI:10.1097/SCS.0000000000006301.
[21] Lackner H,Karastaneva A,Schwinger W,et al.Sirolimus for the treatment of children with various complicated vascular anomalies[J].Eur J Pediatr,2015,174(12):1579-1584.DOI:10.1007/s00431-015-2572-y.
[22] Yano T,Kobayashi T,Kuroda S,et al.Obstructive jaundice caused by a giant liver hemangioma with Kasabach-Merritt syndrome:a case report[J].Surg Case Rep,2015,1(1):93.DOI:10.1186/s40792-015-0095-4.
[23] Li JX,Zhuo SJ,Chen BH,et al.Clinical efficacy of laparoscopic modified loop cholecystojejunostomy for the treatment of malignant obstructive jaundice[J].J Int Med Res,2020,48(2):300060519866285.DOI:10.1177/0300060519866285.
[24] 温哲,张宾宾.儿童肝前性门静脉高压的术前评估及手术治疗[J].临床小儿外科杂志,2019,18(12):994-998.DOI:10.3969/j.issn.1671-6353.2019.12.002. Wen Z,Zhang BB.Preoperative assessments and operations for prehepatic portal hypertension in children[J].J Clin Ped Sur,2019,18(12):994-998.DOI:10.3969/j.issn.1671-6353.2019.12.002.
[25] 孙蕊,李龙.儿童门静脉海绵样变性的外科手术治疗研究进展[J].临床小儿外科杂志,2020,19(12):1145-1151.DOI:10.3969/j.issn.1671-6353.2020.12.016. Sun R,Li L.Research advances of surgery for cavernous transformation of portal vein in children[J].J Clin Ped Sur,2020,19(12):1145-1151.DOI:10.3969/j.issn.1671-6353.2020.12.016.
相似文献/References:
[1]李军 常晓峰 伏利兵. 小儿肝脏血管内皮细胞瘤组织中VEGF表达的研究[J].临床小儿外科杂志,2014,13(02):122.
备注/Memo
收稿日期:2021-11-14。
基金项目:广东省基础与应用基础研究基金(2019A1515011086)
通讯作者:吴凯,Email:aibeike@126.com