Lü Yanwei,Wang Dan,Hu Lianghao.Analytical review of endoscopic treatments in pediatric chronic pancreatitis[J].Journal of Clinical Pediatric Surgery,2021,20(07):606-611.[doi:10.12260/lcxewkzz.2021.07.002]
儿童慢性胰腺炎内镜治疗进展
- Title:
- Analytical review of endoscopic treatments in pediatric chronic pancreatitis
- Keywords:
- Pancreatitis; Chronic/DI; Pancreatitis; Chronic/TH; Endoscopic Retrograde Cholangiopancreatography; Interventional Endoscopic Ultrasound; Treatment Outcome
- 分类号:
- R725.762;R443.7
- 摘要:
- 慢性胰腺炎是指由各种病因引起的胰腺组织和（或）功能发生不可逆性改变的一种慢性炎症性疾病，近年来其发病率和患病率均呈上升趋势，患者腹痛反复发作及营养物质吸收不良将严重影响其生长发育和智力发展。较成人而言，儿童慢性胰腺炎具有基因突变发生率高、疼痛评估难度大的特点，且儿童耐受性和自控力差。经内镜逆行胰胆管造影和介入性超声内镜等微创治疗较外科治疗具有创伤小、恢复快、可重复性强等优点，可明显缓解临床症状。本文旨在阐述近年来儿童慢性胰腺炎内镜微创治疗的研究进展。
- Abstract:
- Chronic Pancreatitis is a chronic inflammatory disease caused by a variety of reasons,with irreversible changes in pancreatic tissue and/or function.In recent years,the prevalence and morbidity of pediatric chronic pancreatitis is on the rise.Repeated abdominal pain and malabsorption can have severe influence on growth and intelligence development of children.Compared to adult patients,pediatric patients have some unique characteristics such as high incidence of gene mutation,difficulty of accurate pain evaluation,low endurance and poor self-control.Unlike surgery,endoscopic treatments such as Endoscopic retrograde cholangiopancreatography(ERCP) and Interventional Endoscopic Ultrasound(EUS) are minimally-invasive and repeatable,from which patients can get a good recovery more quickly,with clinical symptoms relieved significantly.This article is a review about the progression of minimally-invasive endoscopic treatments in pediatric chronic pancreatitis.
参考文献/References:
1 彭飞,孙贝贝,郑凯,等.小儿胰腺真性囊肿1例诊治分析并文献复习[J].临床小儿外科杂志,2019,18(11):987-988.DOI:10.3969/j.issn.1671-6353.2019.11.018. Peng F,Sun BB,Zheng K,et al.Diagnosis,treatment and literature review of a case of pediatric pancreatic true cyst[J].J Clin Ped Sur,2019,18(11):987-988.DOI:10.3969/j.issn.1671-6353.2019.11.018.
2 邓玉华,张明满,郭泓伶,等.4例儿童胰十二指肠切除术的临床疗效分析[J].临床小儿外科杂志,2019,18(6):498-502.DOI:10.3969/j.issn.1671-6353.2019.06.012. Deng YH,Zhang MM,Guo HL,et al.Clinical analysis of 4 cases of pancreaticoduodenectomy in children[J].J Clin Ped Sur,2019,18(6):498-502.DOI:10.3969/j.issn.1671-6353.2019.06.012.
3 Kumar S,Ooi CY,Werlin S,et al.Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis:Lessons From INSPPIRE[J].JAMA Pediatr,2016,170(6):562-569.DOI:10.1001/jamapediatrics.2015.4955.
4 Husain SZ,Morinville V,Pohl J,et al.Toxic-metabolic Risk Factors in Pediatric Pancreatitis:Recommendations for Diagnosis,Management,and Future Research[J].J Pediatr Gastroenterol Nutr,2016,62(4):609-617.DOI:10.1097/MPG.0000000000001035.
5 Kolodziejczyk E,Wejnarska K,Dadalski M,et al.The nutritional status and factors contributing to malnutrition in children with chronic pancreatitis[J].Pancreatology,2014,14(4):275-279.DOI:10.1016/j.pan.2014.04.030.
6 Schwarzenberg SJ,Bellin M,Husain SZ,et al.Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden[J].J Pediatr,2015,166(4):890-896.e891.DOI:10.1016/j.jpeds.2014.11.019.
7 Wang D,Bi YW,Ji JT,et al.Extracorporeal shock wave lithotripsy is safe and effective for pediatric patients with chronic pancreatitis[J].Endoscopy,2017,49(5):447-455.DOI:10.1055/s-0043-104527.
8 Hao L,Wang T,He L,et al.Risk factor for steatorrhea in pediatric chronic pancreatitis patients[J].BMC Gastroenterol,2018,18(1):182.DOI:10.1186/s12876-018-0902-z.
9 Morinville VD,Husain SZ,Bai H,et al.Definitions of pediatric pancreatitis and survey of present clinical practices[J].J Pediatr Gastroenterol Nutr,2012,55(3):261-265.DOI:10.1097/MPG.0b013e31824f1516.
10 Kohoutova D,Tringali A,Papparella G,et al.Endoscopic treatment of chronic pancreatitis in pediatric population:Long-term efficacy and safety[J].United European Gastroenterol J,2019,7(2):270-277.DOI:10.1177/2050640618817699.
11 Waye JD.Endoscopic retrograde cholangiopancreatography in the infant[J].Am J Gastroenterol,1976,65(5):461-463.
12 Hatlani MA,Kortan P,May G,et al.Wire-guided cannulation versus contrast-guided cannulation in pediatric endoscopic retrograde cholangiopancreatography[J].Saudi J Gastroenterol,2015,21(1):25-29.DOI:10.4103/1319-3767.151219.
13 Tringali A,Thomson M,Dumonceau J,et al.Pediatric gastrointestinal endoscopy:European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Guideline Executive summary[J].Endoscopy,2017,49(1):83-91.DOI:10.1055/s-0042-111002.
14 Muftah M,Shah R,Fritzen C,et al.Endoscopic Retrograde Cholangiopancreatography in Pediatric Populations[J].Curr Treat Options Gastroenterol,2019,17(1):165-170.DOI:10.1007/s11938-019-00225-6.
15 Agarwal J,Nageshwar Reddy D,Talukdar R,et al.ERCP in the management of pancreatic diseases in children[J].Gastrointest Endosc,2014,79(2):271-278.DOI:10.1016/j.gie.2013.07.060.
16 Giefer MJ,Kozarek RA.Technical outcomes and complications of pediatric ERCP[J].Surg Endosc,2015,29(12):3543-3550.DOI:10.1007/s00464-015-4105-1.
17 Teng R,Yokohata K,Utsunomiya N,et al.Endoscopic retrograde cholangiopancreatography in infants and children[J].J Gastroenterol,2000,35(1):39-42.DOI:10.1007/pl00009974.
18 Thomson M,Tringali A,Dumonceau JM,et al.Paediatric Gastrointestinal Endoscopy:European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines[J].J Pediatr Gastroenterol Nutr,2017,64(1):133-153.DOI:10.1097/MPG.0000000000001408.
19 Felux J,Sturm E,Busch A,et al.ERCP in infants,children and adolescents is feasible and safe:results from a tertiary care center[J].United European Gastroenterol J,2017,5(7):1024-1029.DOI:10.1177/2050640616687868.
20 Keil R,Drabek J,Lochmannova J,et al.ERCP in infants,children,and adolescents-Different roles of the methods in different age groups[J].PLoS One,2019,14(1):e0210805.DOI:10.1371/journal.pone.0210805.
21 Usatin D,Fernandes M,Allen IE,et al.Complications of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients; A Systematic Literature Review and Meta-Analysis[J].J Pediatr,2016,179:160-165.e3.DOI:10.1016/j.jpeds.2016.08.046.
22 Committee Asop,Chandrasekhara V,Khashab MA,et al.Adverse events associated with ERCP[J].Gastrointest Endosc,2017,85(1):32-47.DOI:10.1016/j.gie.2016.06.051.
23 Shah R,Cohen RZ,Mekaroonkamol P,et al.Retrospective Multicenter Matched Controlled Comparison of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients:A 10-year Experience[J].J Pediatr Gastroenterol Nutr,2020,70(5):568-573.DOI:10.1097/MPG.0000000000002632.
24 Rosen JD,Lane RS,Martinez JM,et al.Success and safety of endoscopic retrograde cholangiopancreatography in children[J].J Pediatr Surg,2017,52(7):1148-1151.DOI:10.1016/j.jpedsurg.2017.01.051.
25 Goetz M,Andersen P,Bergman J,et al.ERCP in babies:Low risk of post-ERCP pancreatitis-results from a multicentre survey[J].United European Gastroenterol J,2020,8(1):77-80.DOI:10.1177/2050640619874187.
26 Choudhary A,Bechtold ML,Arif M,et al.Pancreatic stents for prophylaxis against post-ERCP pancreatitis:a meta-analysis and systematic review[J].Gastrointest Endosc,2011,73(2):275-282.DOI:10.1016/j.gie.2010.10.039.
27 Mercier C,Pioche M,Albuisson E,et al.Safety of endoscopic retrograde cholangiopancreatography in the pediatric population:a multicenter study[J].Endoscopy,2020,53(6):586-594.DOI:10.1055/a-1209-0155.
28 Troendle DM,Abraham O,Huang R,et al.Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population[J].Gastrointest Endosc,2015,81(6):1408-1416.DOI:10.1016/j.gie.2014.11.022.
29 Pauwels R,Horner K,Vassileva J,et al.Thyroid shielding in cone beam computed tomography:recommendations towards appropriate use[J].Dentomaxillofac Radiol,2019,48(7):20190014.DOI:10.1259/dmfr.20190014.
30 Li ZS,Wang W,Liao Z,et al.A long-term follow-up study on endoscopic management of children and adolescents with chronic pancreatitis[J].Am J Gastroenterol,2010,105(8):1884-1892.DOI:10.1038/ajg.2010.85.
31 Dumonceau JM,Delhaye M,Tringali A,et al.Endoscopic treatment of chronic pancreatitis:European Society of Gastrointestinal Endoscopy (ESGE) Guideline-Updated August 2018[J].Endoscopy,2019,51(2):179-193.DOI:10.1055/a-0822-0832.
32 Patel PA,Gibson C,Minhas KS,et al.Pancreatic pseudocyst drainage in children by image-guided cystogastrostomy and stent insertion[J].Pediatr Radiol,2019,49(13):1816-1822.DOI:10.1007/s00247-019-04471-9.
33 Rosenfeld EH,Vogel AM,Jafri M,et al.Management and outcomes of peripancreatic fluid collections and pseudocysts following non-operative management of pancreatic injuries in children[J].Pediatr Surg Int,2019,35(8):861-867.DOI:10.1007/s00383-019-04492-3.
34 Dumonceau JM,Tringali A,Papanikolaou IS,et al.Endoscopic biliary stenting:indications,choice of stents,and results:European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline-Updated October 2017[J].Endoscopy,2018,50(9):910-930.DOI:10.1055/a-0659-9864.
35 Halvorson L,Halsey K,Darwin P,et al.The safety and efficacy of therapeutic ERCP in the pediatric population performed by adult gastroenterologists[J].Dig Dis Sci,2013,58(12):3611-3619.DOI:10.1007/s10620-013-2857-9.
36 Gordon K,Conway J,Evans J,et al.EUS and EUS-Guided Interventions Alter Clinical Management in Children With Digestive Diseases[J].J Pediatr Gastroenterol Nutr,2016,63(2):242-246.DOI:10.1097/MPG.0000000000001101.
37 Patel S,Marshak J,Daum F,et al.The emerging role of endoscopic ultrasound for pancreaticobiliary diseases in the pediatric population[J].World J Pediatr,2017,13(4):300-306.DOI:10.1007/s12519-017-0020-y.
38 Seicean A,Vultur S.Endoscopic therapy in chronic pancreatitis:current perspectives[J].Clin Exp Gastroenterol,2015,8:1-11.DOI:10.2147/CEG.S43096.
39 Tellez-Avila FI,Duarte-Medrano G,Herrera-Mora D,et al.Endoscopic Ultrasound in Pediatric Patients With Pancreatobiliary Disease[J].Surg Laparosc Endosc Percutan Tech,2019,29(4):271-274.DOI:10.1097/SLE.0000000000000673.
40 Fugazza A,Bizzarri B,Gaiani F,et al.The role of endoscopic ultrasound in children with Pancreatobiliary and gastrointestinal disorders:a single center series and review of the literature[J].BMC Pediatr,2017,17(1):203.DOI:10.1186/s12887-017-0956-z.
41 Jazrawi SF,Barth BA,Sreenarasimhaiah J.Efficacy of endoscopic ultrasound-guided drainage of pancreatic pseudocysts in a pediatric population[J].Dig Dis Sci,2011,56(3):902-908.DOI:10.1007/s10620-010-1350-y.
42 Scheers I,Ergun M,Aouattah T,et al.Diagnostic and Therapeutic Roles of Endoscopic Ultrasound in Pediatric Pancreaticobiliary Disorders[J].J Pediatr Gastroenterol Nutr,2015,61(2):238-247.DOI:10.1097/MPG.0000000000000692.
43 Nabi Z,Lakhtakia S,Basha J,et al.Endoscopic drainage of pancreatic fluid collections:Long-term outcomes in children[J].Dig Endosc,2017,29(7):790-797.DOI:10.1111/den.12884.
相似文献/References:
[1]文勇,杨闻晓.小儿重症胰腺炎18例诊治分析[J].临床小儿外科杂志,2008,7(04):0.
[2]潘祝彬 高群 黄河. 早期肠内营养在小儿急性胰腺炎治疗中的应用[J].临床小儿外科杂志,2012,11(06):436.
[J].Journal of Clinical Pediatric Surgery,2012,11(07):436.
[3]刁维,何凤.早期经口进食对小儿轻症急性胰腺炎的疗效影响[J].临床小儿外科杂志,2021,20(07):631.[doi:10.12260/lcxewkzz.2021.07.007]
Diao Wei,He Feng.Therapeutic effect of early oral feeding on pediatric mild acute pancreatitis[J].Journal of Clinical Pediatric Surgery,2021,20(07):631.[doi:10.12260/lcxewkzz.2021.07.007]
备注/Memo
收稿日期:2021-05-02。
基金项目:国家自然科学基金（编号：82070664、81900590、81770635）；上海市科技创新行动计划技术标准项目（编号：19DZ12201900）；上海市卫计委智慧医疗专项（编号：2018ZHYL0229）；上海市扬帆计划（编号：19YF1446800）；上海市曙光计划（编号：20SG36）；上海市晨光计划（编号：20CG42）
通讯作者:胡良皞,Email:lianghao-hu@hotmail.com