Long Hongyu,He Li.Research advances on the role of regulatory T cells in the pathogenesis of neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,2026,(08):796-800.[doi:10.3760/cma.j.cn101785-202409052]
调节T细胞参与新生儿坏死性小肠结肠炎发病机制的研究进展
- Title:
- Research advances on the role of regulatory T cells in the pathogenesis of neonatal necrotizing enterocolitis
- 关键词:
- 新生儿坏死性小肠结肠炎; 调节性T细胞; 免疫调节; 发病机制
- 摘要:
- 新生儿坏死性小肠结肠炎（neonatal necrotizing enterocolitis,NEC）是一种严重的新生儿肠道炎症性疾病，具有病情进展快、病死率高的特点，多见于早产儿和低出生体重儿。NEC发病机制复杂，涉及肠道微生物平衡失调、免疫介导肠道损伤等多个方面，目前尚未完全阐明。调节性T（regulatory T，Treg）细胞作为免疫系统的关键调节因子，在NEC发病过程中的作用及机制日益受到重视，并可能作为NEC的潜在治疗靶点。本文旨在综述Treg细胞在NEC发病机制中的作用机制研究进展，为临床诊疗提供新思路。
- Abstract:
- As a severe intestinal inflammatory disease in neonates,neonatal necrotizing enterocolitis (NEC) is characterized by a rapid disease progression and a high mortality.It is more common in premature and low-birth-weight infants.The pathogenesis of NEC is rather complex,involving intestinal microbial imbalance,immune-mediated intestinal injury and other aspects.However,its underlying pathogenesis has not been fully elucidated.As a key regulator of immune system in the pathogenesis of NEC,regulatory T (Treg) cells have attracted growing attention.It may be a potential therapeutic target for NEC.This review summarized the latest researches of Treg cells in the pathogenesis of NEC to provide new rationales for its clinical diagnosis and treatment.
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备注/Memo
收稿日期:2024-9-20。
通讯作者:何丽,Email:804406304@qq.com