Zhu Yufei,Xie Hua,Tang Weibing.Research advances of crosstalking between biliary epithelial cell and immune cells in biliary atresia[J].Journal of Clinical Pediatric Surgery,2026,(06):596-600.[doi:10.3760/cma.j.cn101785-202412050]
胆道闭锁中胆管上皮细胞与免疫细胞相互作用的研究进展
- Title:
- Research advances of crosstalking between biliary epithelial cell and immune cells in biliary atresia
- Keywords:
- Biliary Atresia; Bile Ducts; Physiopathology; Bile Ducts; Epithelial Cells; Immunocyte
- 摘要:
- 胆道闭锁(biliary atresia,BA)是以肝内、外胆管炎性闭塞和进行性肝纤维化为特征的新生儿/婴儿胆管疾病。胆管上皮细胞(biliary epithelial cell,BEC)是BA免疫反应的关键环节,其可发挥屏障功能、参与固有免疫调节,并可在损伤后诱发过度免疫激活,加剧炎症反应。同时,免疫系统功能失调以BEC为损伤靶点,促进BA的发生与进展。因此,精准靶向BEC和免疫系统交互的关键分子,并调控免疫反应平衡以促进胆管修复和组织再生,可望为BA的辅助治疗提供新的策略和方向。本文就BA中BEC与免疫系统之间的相互作用及机制进行综述。
- Abstract:
- As one of infantile bile duct diseases,biliary atresia (BA) is characterized by phlogistic obstruction of external bile duct and progressive liver fibrosis.Biliary epithelial cell (BEC) is a critical cell type during BA immune response.With barrier function of regulating innate immune response,it can also induce excessive immune activation to accelerate the inflammatory response after injury.In addition,immune system dysfunction may disrupt BEC,leading to the occurrence and progression of BA.Therefore targeting key molecules between the interaction of BEC and immune system precisely and modulating their balance during bile duct repair and regeneration,may provide a novel strategy for promising adjuvant treatment of BA.This review focused upon crosstalking between BEC and immune system in BA.
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备注/Memo
收稿日期:2024-12-17。
基金项目:国家自然科学基金(82370523)
通讯作者:唐维兵,Email:twbcn@163.com