[1]计凤鸣,张黄成昊,张昆,等.儿童纵膈节细胞性神经母细胞瘤合并左侧肾上腺皮质癌同时性多原发癌1例[J].临床小儿外科杂志,2025,(08):793-795.[doi:10.3760/cma.j.cn101785-202309014-016]
　Ji Fengming,Zhang Huangchenghao,Zhang Kun,et al.A case report of synchronous multiple primary cancers: mediastinal ganglioneuroblastoma with left adrenocortical carcinoma in a child[J].Journal of Clinical Pediatric Surgery,2025,(08):793-795.[doi:10.3760/cma.j.cn101785-202309014-016]
点击复制

儿童纵膈节细胞性神经母细胞瘤合并左侧肾上腺皮质癌同时性多原发癌1例

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 期数: 2025年08 页码: 793-795 栏目: 病例报告 出版日期: 2025-08-28
Title:
A case report of synchronous multiple primary cancers: mediastinal ganglioneuroblastoma with left adrenocortical carcinoma in a child
作者:
计凤鸣1;  张黄成昊1;  张昆1;  宋元华2;  严兵1;  杨震2
1. 昆明医科大学附属儿童医院泌尿外科, 昆明 650100;
2. 昆明医科大学附属儿童医院肿瘤科, 昆明 650100
Author(s):
Ji Fengming1;  Zhang Huangchenghao1;  Zhang Kun1;  Song Yuanhua2;  Yan Bing1;  Yang Zhen2
1 Department of Urology, Affiliated Children’s Hospital, Kunming Medical University, Kunming 650100, China;
2 Department of Oncology, Affiliated Children’s Hospital, Kunming Medical University, Kunming 650100, China
关键词:
肿瘤;  多原发性; 神经母细胞瘤;  纵膈; 节细胞性神经母细胞瘤; 肾上腺皮质癌; 儿童
DOI:
10.3760/cma.j.cn101785-202309014-016
摘要:
本文报道1例儿童肾上腺皮质癌合并节细胞性神经母细胞瘤的多原发癌个案,探讨儿童肾上腺皮质癌和神经母细胞瘤的临床特点及诊治要点,并通过文献复习,总结儿童多原发癌的治疗经验。

参考文献/References:

[1] Zhai CY,Cai YL,Lou F,et al.Multiple primary malignant tumors-A clinical analysis of 15,321 patients with malignancies at a single center in China[J].J Cancer,2018,9(16):2795-2801.DOI:10.7150/jca.25482.
[2] Alhamadh MS,Alanazi RB,Algarni ST,et al.A descriptive study of the types and survival patterns of Saudi patients with multiple primary solid malignancies:a 30-year tertiary care center experience[J].Curr Oncol,2022,29(7):4941-4955.DOI:10.3390/curroncol29070393.
[3] 王鑫,俞凯杰,詹镇润,等.同时性三重原发癌合并胃间质瘤1例[J].肿瘤预防与治疗,2023,36(7):611-615.DOI:10.3969/j.issn.1674-0904.2023.07.011. Wang X,Yu KJ,Zhan ZR,et al.Simultaneous triple primary malignancies plus gastric stromal tumor:one case report[J].J Cancer Control Treat,2023,36(7):611-615.DOI:10.3969/j.issn.1674-0904.2023.07.011.
[4] Li R,Polishchuk A,DuBois S,et al.Patterns of relapse in high-risk neuroblastoma patients treated with and without total body irradiation[J].Int J Radiat Oncol Biol Phys,2017,97(2):270-277.DOI:10.1016/j.ijrobp.2016.10.047.
[5] Zeineldin M,Patel AG,Dyer MA.Neuroblastoma:when differentiation goes awry[J].Neuron,2022,110(18):2916-2928.DOI:10.1016/j.neuron.2022.07.012.
[6] 杨瑞雪,王晓琳,王一超,等.结节型节细胞神经母细胞瘤3例并文献复习[J].中国组织化学与细胞化学杂志,2020,29(3):264-267,273.DOI:10.16705/j.cnki.1004-1850.2020.03.011. Yang RX,Wang XL,Wang YC,et al.Nodular ganglioneuroblastoma:a report of 3 cases with a literature review[J].Chin J Histochem Cytochem,2020,29(3):264-267,273.DOI:10.16705/j.cnki.1004-1850.2020.03.011.
[7] 中国医师协会泌尿外科分会.肾上腺皮质癌诊治专家共识[J].现代泌尿外科杂志,2021,26(11):902-908.DOI:10.3969/j.issn.1009-8291.2021.11.002. Branch of Urology,Chinese Medical Doctor Association.Expert Consensus on Diagnosing and Treating Adrenal Cortical Cancer[J].J Mod Urol,2021,26(11):902-908.DOI:10.3969/j.issn.1009-8291.2021.11.002.
[8] Li P,Su XN,Zhang XT,et al.Prognostic factors of adrenocortical carcinoma:experience from a regional medical center in eastern China[J].Int J Gen Med,2023,16:453-465.DOI:10.2147/IJGM.S399473..
[9] Zhang SL,Xiao BL,Zhang YW,et al.Retroperitoneal ganglioneuroblastoma with postoperative stress ulcer perforation in an adolescent:a case report and review of the literature[J].Oncol Lett,2022,24(1):208.DOI:10.3892/ol.2022.13329.
[10] Zhang QY,Zhou TT,Hou PM,et al.A single-center study of thoracoscopic surgery in the treatment of pediatric mediastinal neurogenic tumors[J].Thorac Cancer,2023,14(1):44-51.DOI:10.1111/1759-7714.14708.
[11] Heidari Z,Kaykhaei MA,Jahantigh M,et al.Adrenal ganglioneuroblastoma in an adult:a rare case report[J].Int J Endocrinol Metab,2018,16(1):e63055.DOI:10.5812/ijem.63055.
[12] 王浩入,陈欣,张黎,等.儿童腹膜后结节型和混合型节细胞神经母细胞瘤的临床及CT表现[J].中国临床医学影像杂志,2022,33(4):279-282.DOI:10.12117/jccmi.2022.04.011. Wang HR,Chen X,Zhang L,et al.CT findings and clinical features of retroperitoneal nodular and intermixed ganglioneuroblastoma in children[J].J Chin Clin Med Imaging,2022,33(4):279-282.DOI:10.12117/jccmi.2022.04.011.
[13] He WG,Yan Y,Tang W,et al.Clinical and biological features of neuroblastic tumors:a comparison of neuroblastoma and ganglioneuroblastoma[J].Oncotarget,2017,8(23):37730-37739.DOI:10.18632/oncotarget.17146.
[14] 张琼,任静祎,纪洪辰,等.肾上腺皮质癌1例报道并文献回顾[J].现代肿瘤医学,2021,29(23):4153-4158.DOI:10.3969/j.issn.1672-4992.2021.23.017. Zhang Q,Ren JY,Ji HC,et al.Adrenocortical carcinoma:one case report with a literature review[J].J Mod Oncol,2021,29(23):4153-4158.DOI:10.3969/j.issn.1672-4992.2021.23.017.
[15] Lai GC,Liu H,Deng JL,et al.The characteristics of tumor microenvironment predict survival and response to immunotherapy in adrenocortical carcinomas[J].Cells,2023,12(5):755.DOI:10.3390/cells12050755.
[16] Margonis GA,Kim Y,Prescott JD,et al.Adrenocortical carcinoma:impact of surgical margin status on long-term outcomes[J].Ann Surg Oncol,2016,23(1):134-141.DOI:10.1245/s10434-015-4803-x.
[17] Fassnacht M,Assie G,Baudin E,et al.Adrenocortical carcinomas and malignant phaeochromocytomas:ESMO-EURACAN Clinical Practice Guidelines for diagnosis,treatment and follow-up[J].Ann Oncol,2020,31(11):1476-1490.DOI:10.1016/j.annonc.2020.08.2099.
[18] Hescot S,Debien V,Hadoux J,et al.Outcome of adrenocortical carcinoma patients included in early phase clinical trials:results from the French network ENDOCAN-COMETE[J].Eur J Cancer,2023,189:112917.DOI:10.1016/j.ejca.2023.05.006.
[19] Fassnacht M,Terzolo M,Allolio B,et al.Combination chemotherapy in advanced adrenocortical carcinoma[J].N Engl J Med,2012,366(23):2189-2197.DOI:10.1056/NEJMoa1200966.
[20] Nyqvist J,Kovács A,Einbeigi Z,et al.Genetic alterations associated with multiple primary malignancies[J].Cancer Med,2021,10(13):4465-4477.DOI:10.1002/cam4.3975.
[21] Riedmeier M,Antonini SRR,Brandalise S,et al.International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors:indications,therapy,and management of adverse effects[J].Eur J Endocrinol,2024,190(4):G15-G24.DOI:10.1093/ejendo/lvae038.

相似文献/References:

[1]匡玉婷 赵斯君 李 赟.鼻内镜下电动吸割器治疗小儿喉乳头状瘤临床分析[J].临床小儿外科杂志,2010,9(04):0.
[2]邹华新,刘铭.Rb和P21基因在婴幼儿皮肤血管瘤中的表达及意义[J].临床小儿外科杂志,2008,7(04):0.
[3]刘洲禄,肖元宏,陈迪祥,等.儿童腹膜后肿瘤累及重要血管的手术处理[J].临床小儿外科杂志,2008,7(06):4.
[4]吕然博. 小脑延髓裂入路手术切除儿童第四脑室肿瘤[J].临床小儿外科杂志,2011,10(03):196.
　[J].Journal of Clinical Pediatric Surgery,2011,10(08):196.
[5]李长春 王珊 章均 欧阳军 孔祥如 杨超 赵珍珍 吕麟亚. B超引导下芯针穿刺活检术诊断儿童实体肿瘤的临床分析[J].临床小儿外科杂志,2011,10(04):247.
　[J].Journal of Clinical Pediatric Surgery,2011,10(08):247.
[6]刘菁 张晓伦 包楠 李龙 陈晓波. 小儿恶性肿瘤合并抗利尿激素分泌失调综合征3例[J].临床小儿外科杂志,2011,10(04):312.
　[J].Journal of Clinical Pediatric Surgery,2011,10(08):312.
[7]殷敏智 陈其民 张忠德 马 靖 吴湘如 施诚仁.儿童胸部炎性肌纤维母细胞瘤的临床病理探讨[J].临床小儿外科杂志,2013,12(02):97.[doi:10.3969/j.issn.1671— 6353.2013.02.006]
　YIN Min-zhi,CHEN Qi-min,ZHANG Zhong-de,et al.he analysis of paediatric inflammatory myofibroblastic tumor’s clinicopathological features,lectures review[J].Journal of Clinical Pediatric Surgery,2013,12(08):97.[doi:10.3969/j.issn.1671— 6353.2013.02.006]
[8]赵瑞,周渊峰,杨皓玮,等.儿童颞叶癫痫的临床特点及手术疗效分析[J].临床小儿外科杂志,2018,17(04):269.
　Zhao Rui,Zhou Yuanfeng,Yang Haowei,et al.Clinical characteristics and surgical treatment of temporal lobe epilepsy in children.[J].Journal of Clinical Pediatric Surgery,2018,17(08):269.
[9]侯培民,王东明,张强业,等.腔镜技术在小儿肿瘤切除手术中的应用及技巧探讨[J].临床小儿外科杂志,2019,18(04):277.[doi:10.3969/j.issn.1671-6353.2019.04.006]
　Hou Peimin,Wang Dongming,Zhang Qiangye,et al.Application and skill exploration of laparoscopic and thoracoscopic technology in pediatric tumor resection[J].Journal of Clinical Pediatric Surgery,2019,18(08):277.[doi:10.3969/j.issn.1671-6353.2019.04.006]
[10]郭强,张伟,朱丹.儿童致痫性低级别肿瘤的手术策略与切除范围设计[J].临床小儿外科杂志,2019,18(09):719.[doi:10.3969/j.issn.1671-6353.2019.09.002]
　Guo Qiang,Zhang Wei,Zhu Dan.Surgical strategies and scope of resecting epileptic low-grade tumors in children[J].Journal of Clinical Pediatric Surgery,2019,18(08):719.[doi:10.3969/j.issn.1671-6353.2019.09.002]

备注/Memo

收稿日期:2023-9-6。
通讯作者:杨震,Email:15925202466@163.com

更新日期/Last Update: 2025-08-28