Zhang Minzhong,Wang Jun.Prenatal diagnosis of congenital digestive tract anomalies and assessing its clinical value[J].Journal of Clinical Pediatric Surgery,2025,(08):706-712.[doi:10.3760/cma.j.cn101785-202412069-002]
先天性消化道畸形产前诊断及其临床价值
- Title:
- Prenatal diagnosis of congenital digestive tract anomalies and assessing its clinical value
- Keywords:
- Congenital Digestive Tract Anomaly; Intestinal Atresia; Meconium Peritonitis; Esophageal Atresia; Prenatal Diagnosis; Clinical Assessment
- 摘要:
- 先天性消化道畸形是一类于胎儿发育过程中出现的结构性异常,这种异常不仅影响新生儿的生命质量,还可能威胁其生命安全。随着高分辨率超声检查、胎儿磁共振成像和二代测序遗传学检测等产前诊断技术的发展,消化道畸形的产前检出率日益增高。通过产前诊断早期准确评估畸形种类、严重程度及预后情况,并在多学科合作的框架下适时给出产前处理建议以及生后处理流程,可进一步提高先天性消化道畸形的诊治效果,改善预后。本文以先天性肠闭锁、胎粪性腹膜炎和长段缺失型食管闭锁为例,探讨先天性消化道畸形的产前诊断方法及处理策略,供临床参考。
- Abstract:
- Congenital digestive tract anomalies are a diverse class of structural abnormalities occurring during fetal development.It not only affects the quality-of-life of neonates but also threatens their lives.With the rapid developments of such medical technologies as high-resolution ultrasoound,fetal magnetic resonance imaging and next-generation sequencing,a growing number of digestive tract anomalies may be detected and diagnosed prenatally.Timely and accurate prenatal diagnosis enables clinicians to assess the risks of fetal digestive tract anomalies and examine various risk factors of fetal wellbeing.It seriously affects important organ functions and cause serious short/long-term complications.Appropriate measures of multidisciplinary treatments should be adopted for eliminating risks and improving outcomes.The examples of congenital intestinal atresia,meconium peritonitis and long-gap esophageal atresia were selected as case studies for illustrating comprehensively the techniques of prenatal diagnosis and clinical management of congenital digestive tract anomalies,aiming to provide reference for clinicians and promote further research and development in this field.
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备注/Memo
收稿日期:2024-12-31。
基金项目:申康临床三年行动计划疑难疾病诊治攻关项目(SHDC2020CR2063B);上海交通大学医学院儿科学院食管闭锁临床研究中心(ELYZX 202202);上海市科技创新行动计划生物医药科技支撑专项(22S31904200);上海市卫生健康委员会卫生行业临床研究专项(20234Y0053)
通讯作者:王俊,Email:jwangjl@126.com