Fu Shuqi,Li Ji,Wang Lei,et al.Research advances of biomarkers related to congenital hydronephrosis[J].Journal of Clinical Pediatric Surgery,2024,(09):893-897.[doi:10.3760/cma.j.cn101785-202308037-017]
先天性肾积水相关生物标志物的研究进展
- Title:
- Research advances of biomarkers related to congenital hydronephrosis
- Keywords:
- Hydronephrosis; Congenital; Biomarkers; Child
- 摘要:
- 先天性肾积水是儿童常见泌尿系统疾病,目前针对肾积水严重程度及手术指征的最佳评估策略尚未达成共识,国内外研究人员试图在生物标志物中寻求突破。本文就先天性肾积水目前常用或有潜在提示意义的生物标志物做一综述。
- Abstract:
- Congenital hydronephrosis (CHn) is a common urinary system disease in children.Currently there is no consensus on the severity of CHn and the optimal evaluation strategy for its surgical indications.Domestic and foreign researchers are trying to seek breakthroughs in biomarkers.This review summarized common or potentially suggestive biomarkers for CHn.
参考文献/References:
[1] 孙宁,郑珊.小儿外科学[M].北京:人民卫生出版社,2015. Sun N,Zheng S.Pediatric Surgery[M].Beijing:People’s Medical Publishing House,2015.
[2] 中华医学会小儿外科分会泌尿外科学组.先天性肾盂输尿管交界处梗阻诊疗专家共识[J].中华小儿外科杂志,2018,39(11):804-810.DOI:10.3760/cma.j.issn.0253-3006.2018.11.002. Group of Urology,Branch of Pediatric Surgery,Chinese Medical Association:Expert Consensus on Diagnosing and Treating Congenital Ureteropeivic Junction Obstruction[J].Chin J Pediatr Surg,2018,39(11):804-810.DOI:10.3760/cma.j.issn.0253-3006.2018.11.002.
[3] 胡梅艳,孙晓红.细胞外基质、基质金属蛋白酶与恶性肿瘤关系的研究进展[J].肿瘤药学,2016,6(1):26-30.DOI:10.3969/j.issn.2095-1264.2016.01.06. Hu MY,Sun XH.Research advances of relationship between ECM,MMPs and malignant tumors[J].Anti-Tumor Pharm,2016,6(1):26-30.DOI:10.3969/j.issn.2095-1264.2016.01.06.
[4] Tan TK,Zheng GP,Hsu TT,et al.Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells[J].Am J Pathol,2010,176(3):1256-1270.DOI:10.2353/ajpath.2010.090188.
[5] Zhou D,Tian Y,Sun L,et al.Matrix metalloproteinase-7 is a urinary biomarker and pathogenic mediator of kidney fibrosis[J].J Am Soc Nephrol,2017,28(2):598-611.DOI:10.1681/ASN.2016030354.
[6] He WC,Dai CS,Li YJ,et al.Wnt/beta-catenin signaling promotes renal interstitial fibrosis[J].J Am Soc Nephrol,2009,20(4):765-776.DOI:10.1681/ASN.2008060566.
[7] 秦双利,谢崇,周玲,等.儿童肾盂输尿管连接部梗阻患者尿液中MMP-7和MMP-9的临床意义[J].临床小儿外科杂志,2021,20(7):664-667.DOI:10.12260/lcxewkzz.2021.07.013. Qin SL,Xie C,Zhou L,et al.Evaluation of matrix metalloproteinase-7 and matrix metalloproteinase-9 as biomarkers for ureteropelvic junction obstruction in children[J].J Clin Ped Sur,2021,20(7):664-667.DOI:10.12260/lcxewkzz.2021.07.013.
[8] Bienia[KG-0.92mm]s[DD(-1*9][HT6.]'[HT6] B,Sikora P.Selected metal matrix metalloproteinases and tissue inhibitors of metalloproteinases as potential biomarkers for tubulointerstitial fibrosis in children with unilateral hydronephrosis[J].Dis Markers,2020,2020:9520309.DOI:10.1155/2020/9520309.
[9] Mello MF,Thalita Dos Reis S,Kondo EY,et al.Urinary extracellular matrix proteins as predictors of the severity of ureteropelvic junction obstruction in children[J].J Pediatr Urol,2021,17(4):438.e1-438.e7.DOI:10.1016/j.jpurol.2021.03.017.
[10] Reis ST,Leite KRM,Viana NI,et al.MMP9 overexpression is associated with good surgical outcome in children with UPJO:preliminary results[J].BMC Urol,2016,16(1):44.DOI:10.1186/s12894-016-0162-6.
[11] Bleyer AJ,Kmoch S.Tamm-horsfall glycoprotein and uromodulin:it is all about the tubules[J].Clin J Am Soc Nephrol,2016,11(1):6-8.DOI:10.2215/CJN.12201115.
[12] Kraus D,Wanner C.Uromodulin in the bloodstream:old wine in a new wineskin[J].J Am Soc Nephrol,2017,28(7):1955-1957.DOI:10.1681/ASN.2017040447.
[13] Delgado GE,Kleber ME,Scharnagl H,et al.Serum uromodulin and mortality risk in patients undergoing coronary angiography[J].J Am Soc Nephrol,2017,28(7):2201-2210.DOI:10.1681/ASN.2016111162.
[14] 赵智凝,武易,刘芳,等.慢性肾病患者血清Klotho,HE4,UMOD表达水平与疾病预后的相关性研究[J].现代检验医学杂志,2021,36(2):28-31,56.DOI:10.3969/j.issn.1671-7414.2021.02.007. Zhao ZN,Wu Y,Liu F,et al.Correlation between the expression levels of Klotho,HE4 and uromodulin and the development of chronic kidney disease[J].J Mod Lab Med,2021,36(2):28-31,56.DOI:10.3969/j.issn.1671-7414.2021.02.007.
[15] 尤瑞莲,徐鲁斌,陈丽萌.尿调节素及UMOD基因与慢性肾病的相关性研究进展[J].基础医学与临床,2020,40(4):557-561.DOI:10.3969/j.issn.1001-6325.2020.04.025. You RL,Xu LB,Chen LM.Research advances in the correlation of uromodulin and UMOD gene with chronic kidney diseases[J].Basic Clin Med,2020,40(4):557-561.DOI:10.3969/j.issn.1001-6325.2020.04.025.
[16] Bachmann S.A novel role for Tamm-Horsfall protein (uromodulin) in the renal tubule[J].Kidney Int,2018,94(4):652-655.DOI:10.1016/j.kint.2018.06.023.
[17] Liu Y,Mo L,Goldfarb DS,et al.Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein[J].Am J Physiol Renal Physiol,2010,299(3):F469-F478.DOI:10.1152/ajprenal.00243.2010.
[18] Steubl D,Block M,Herbst V,et al.Plasma uromodulin correlates with kidney function and identifies early stages in chronic kidney disease patients[J].Medicine (Baltimore),2016,95(10):e3011.DOI:10.1097/MD.0000000000003011.
[19] Schaeffer C,Devuyst O,Rampoldi L.Uromodulin:roles in health and disease[J].Annu Rev Physiol,2021,83:477-501.DOI:10.1146/annurev-physiol-031620-092817.
[20] 闫动,张蕾,刘超.糖类抗原19-9作为先天性肾积水生化标志物的研究进展[J].中华小儿外科杂志,2022,43(5):476-480.DOI:10.3760/cma.j.cn421158-20210309-00109. Yan D,Zhang L,Liu C.Research advances of carbohydrate antigen 19-9 as a biochemical marker of congenital hydronephrosis[J].Chin J Pediatr Surg,2022,43(5):476-480.DOI:10.3760/cma.j.cn421158-20210309-00109.
[21] Suzuki K,Muraishi O,Tokue A.The correlation of serum carbohydrate antigen 19-9 with benign hydronephrosis[J].J Urol,2002,167(1):16-20.
[22] Amini E,Pishgar F,Hojjat A,et al.The role of serum and urinary carbohydrate antigen 19-9 in predicting renal injury associated with ureteral stone[J].Ren Fail,2016,38(10):1626-1632.DOI:10.1080/0886022X.2016.1202732.
[23] Miranda EP,Duarte RJ,de Bessa JJr,et al.The role of urinary KIM-1,NGAL,CA19-9 and β2-microglobulin in the assessment of ureteropelvic junction obstruction in adults[J].Biomarkers,2017,22(7):682-688.DOI:10.1080/1354750X.2017.1284264.
[24] Kajbafzadeh AM,Elmi A,Talab SS,et al.Urinary and serum carbohydrate antigen 19-9 as a biomarker in ureteropelvic junction obstruction in children[J].J Urol,2010,183(6):2353-2360.DOI:10.1016/j.juro.2010.02.031.
[25] Fendereski K,Nabighadim A,Seyedtabib M,et al.Comparing predictive values of carbohydrate antigen 19-9,neutrophil gelatinase-associated lipocalin,and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction[J].Pediatr Nephrol,2021,36(3):631-638.DOI:10.1007/s00467-020-04750-w.
[26] ?zkuvanc? V,D?nmez M[KG-1.1mm]I[DD(-*3]·,Ziylan O,et al.Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?[J].J Pediatr Urol,2020,16(6):844.e1-844.e7.DOI:10.1016/j.jpurol.2020.09.005.
[27] Kajbafzadeh AM,Sabetkish S,Sabetkish N.Prognostic significance of maternal urinary carbohydrate antigen 19-9 for antenatal diagnosis of posterior urethral valve associated with fetal hydronephrosis[J].Int Urol Nephrol,2019,51(6):909-915.DOI:10.1007/s11255-019-02138-w.
[28] Akba? M,Koyuncu FM,Artun? Vlkümen B,et al.Can maternal urinary and serum carbohydrate antigen 19-9 concentrations be utilized in the diagnosis of fetal hydronephrosis?[J].J Turk Ger Gynecol Assoc,2020,21(1):41-45.DOI:10.4274/jtgga.galenos.2019.2019.0101.
[29] Omar B,Banke E,Guirguis E,et al.Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes-a role for the transcription factor NFAT and phosphodiesterase 3B[J].Biochem Biophys Res Commun,2012,425(4):812-817.DOI:10.1016/j.bbrc.2012.07.157.
[30] Icer MA,Gezmen-Karadag M.The multiple functions and mechanisms of osteopontin[J].Clin Biochem,2018,59:17-24.DOI:10.1016/j.clinbiochem.2018.07.003.
[31] Vianello E,Kalousová M,Dozio E,et al.Osteopontin:the molecular bridge between fat and cardiac-renal disorders[J].Int J Mol Sci,2020,21(15):5568.DOI:10.3390/ijms21155568.
[32] Kaleta B.The role of osteopontin in kidney diseases[J].Inflamm Res,2019,68(2):93-102.DOI:10.1007/s00011-018-1200-5.
[33] Frangogiannis NG.Matricellular proteins in cardiac adaptation and disease[J].Physiol Rev,2012,92(2):635-688.DOI:10.1152/physrev.00008.2011.
[34] Hudkins KL,Giachelli CM,Cui Y,et al.Osteopontin expression in fetal and mature human kidney[J].J Am Soc Nephrol,1999,10(3):444-457.DOI:10.1681/ASN.V103444.
[35] Xie Y,Sakatsume M,Nishi S,et al.Expression,roles,receptors,and regulation of osteopontin in the kidney[J].Kidney Int,2001,60(5):1645-1657.DOI:10.1046/j.1523-1755.2001.00032.x.
[36] Hara I,Miyake H,Yamanaka K,et al.Expression of CD44 adhesion molecules in nonpapillary renal cell carcinoma and normal kidneys[J].Urology,1999,54(3):562-566.DOI:10.1016/s0090-4295(99)00177-6.
[37] Yamate T,Kohri K,Umekawa T,et al.Interaction between osteopontin on madin darby canine kidney cell membrane and calcium oxalate crystal[J].Urol Int,1999,62(2):81-86.DOI:10.1159/000030363.
[38] Giachelli CM,Pichler R,Lombardi D,et al.Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis[J].Kidney Int,1994,45(2):515-524.DOI:10.1038/ki.1994.67.
[39] Padanilam BJ,Martin DR,Hammerman MR.Insulin-like growth factor I-enhanced renal expression of osteopontin after acute ischemic injury in rats[J].Endocrinology,1996,137(5):2133-2140.DOI:10.1210/endo.137.5.8612558.
[40] Eddy AA,Giachelli CM.Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria[J].Kidney Int,1995,47(6):1546-1557.DOI:10.1038/ki.1995.218.
[41] Wüthrich RP,Fan X,Ritthaler T,et al.Enhanced osteopontin expression and macrophage infiltration in MRL-Fas(lpr) mice with lupus nephritis[J].Autoimmunity,1998,28(3):139-150.DOI:10.3109/08916939808996282.
[42] Magil AB,Pichler RH,Johnson RJ.Osteopontin in chronic puromycin aminonucleoside nephrosis[J].J Am Soc Nephrol,1997,8(9):1383-1390.DOI:10.1681/ASN.V891383.
[43] Nambi P,Gellai M,Wu HL,et al.Upregulation of osteopontin in ischemia-induced renal failure in rats:a role for ET-1?[J].Biochem Biophys Res Commun,1997,241(1):212-214.DOI:10.1006/bbrc.1997.7791.
[44] 张宇,王宏权,李俞润,等.鹿角形肾结石并发肾盂感染的危险因素及肾组织骨桥蛋白、NF-κB表达水平[J].中华医院感染学杂志,2022,32(17):2657-2661.DOI:10.11816/cn.ni.2022-211905. Zhang Y,Wang HQ,Li YR,et al.Risk factors for renal pelvic infection and expression levels of osteopontin and NF-κB in renal tissues of patients with renal staghorn calculi[J].Chin J Nosocomiol,2022,32(17):2657-2661.DOI:10.11816/cn.ni.2022-211905.
[45] Kaneto H,Morrissey J,McCracken R,et al.Osteopontin expression in the kidney during unilateral ureteral obstruction[J].Miner Electrolyte Metab,1998,24(4):227-237.DOI:10.1159/000057375.
[46] Madsen MG,N?rregaard R,Palmfeldt J,et al.Urinary NGAL,cystatin C,β2-microglobulin,and osteopontin significance in hydronephrotic children[J].Pediatr Nephrol,2012,27(11):2099-2106.DOI:10.1007/s00467-012-2217-6.
[47] Madsen MG.Urinary biomarkers in hydronephrosis[J].Dan Med J,2013,60(2):B4582.
[48] Devarakonda CKV,Shearier ER,Hu CR,et al.A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction-A pilot study[J].J Pediatr Urol,2020,16(4):466.e1-466.e9.DOI:10.1016/j.jpurol.2020.05.163.
[49] Chen HH,Lin HW,Xu MS,et al.Quantitative urinary proteome reveals potential biomarkers for ureteropelvic junction obstruction[J].Proteomics Clin Appl,2019,13(4):e1800101.DOI:10.1002/prca.201800101.
[50] 孙婕,孙宁.儿童肾盂输尿管连接部梗阻生物标志物的研究进展[J].中华小儿外科杂志,2021,42(10):949-955.DOI:10.3760/cma.j.cn421158-20200430-00303. Sun J,Sun N.Recent advances of ureteropelvic junction obstruction biomarkers in children[J].Chin J Pediatr Surg,2021,42(10):949-955.DOI:10.3760/cma.j.cn421158-20200430-00303.
[51] Bienia? B,Sikora P.Potential novel biomarkers of obstructive nephropathy in children with hydronephrosis[J].Dis Markers,2018,2018:1015726.DOI:10.1155/2018/1015726.
[52] Karakus S,Oktar T,Kucukgergin C,et al.Urinary IP-10,MCP-1,NGAL,cystatin-C,and KIM-1 levels in prenatally diagnosed unilateral hydronephrosis:the search for an ideal biomarker[J].Urology,2016,87:185-192.DOI:10.1016/j.urology.2015.09.007.
[53] Taha MA,Shokeir AA,Osman HG,et al.Pelvi-ureteric junction obstruction in children:the role of urinary transforming growth factor-beta and epidermal growth factor[J].BJU Int,2007,99(4):899-903.DOI:10.1111/j.1464-410X.2006.06641.x.
[54] Almodhen F,Loutochin O,Capolicchio JP,et al.The role of bladder urine transforming growth factor-beta1 concentrations in diagnosis and management of unilateral prenatal hydronephrosis[J].J Urol,2009,182(1):292-298.DOI:10.1016/j.juro.2009.02.132.
[55] Li ZZ,Zhao ZZ,Liu XH,et al.Prediction of the outcome of antenatal hydronephrosis:significance of urinary EGF[J].Pediatr Nephrol,2012,27(12):2251-2259.DOI:10.1007/s00467-012-2243-4.
[56] Yu L,Zhou L,Li Q,et al.Elevated urinary lipocalin-2,interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction[J].J Pediatr Urol,2019,15(1):44.e1-44.e7.DOI:10.1016/j.jpurol.2018.10.007.
[57] Mohammadjafari H,Rafiei A,Mousavi SA,et al.Role of urinary levels of endothelin-1,monocyte chemotactic peptide-1,and N-acetyl glucosaminidase in predicting the severity of obstruction in hydronephrotic neonates[J].Korean J Urol,2014,55(10):670-676.DOI:10.4111/kju.2014.55.10.670.
[58] Skalova S,Rejtar P,Kutilek S.Increased urinary N-acetyl-beta-D-glucosaminidase activity in children with hydronephrosis[J].Int Braz J Urol,2007,33(1):80-86.DOI:10.1590/s1677-55382007000100014.
[59] Taha MA,Shokeir AA,Osman HG,et al.Diagnosis of ureteropelvic junction obstruction in children:role of endothelin-1 in voided urine[J].Urology,2007,69(3):560-564.DOI:10.1016/j.urology.2006.09.070.
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备注/Memo
收稿日期:2023-8-27。
通讯作者:张谦,Email:shanyan@zzu.edu.cn