Wu Hao,Han Yijiang,Gao Zhigang,et al.Role of bile acids in the progression of biliary atresia and related research advances[J].Journal of Clinical Pediatric Surgery,2024,(08):745-749.[doi:10.3760/cma.j.cn101785-202208047-008]
胆汁酸在胆道闭锁疾病进程中的作用及相关研究进展
- Title:
- Role of bile acids in the progression of biliary atresia and related research advances
- Keywords:
- Biliary Atresia; Bile Acid; Prognosis
- 摘要:
- 胆汁酸作为胆汁的主要成分,具有消化脂质、调节肠道微生物以及调控代谢等生理功能。胆道闭锁患儿往往伴有不同程度的胆汁酸代谢异常。胆汁酸具有两亲性,亲水性较低的胆汁酸通常具有较高的细胞毒性,在胆道闭锁病理状态下,胆汁酸本身的细胞毒性被放大,此为导致一系列病理变化的重要原因之一;而以熊去氧胆酸为代表的亲水性较高的胆汁酸则能明显改善肝功能,这一特性目前已被应用于胆道闭锁的治疗。血清胆汁酸水平随着肝纤维化程度的加重而升高,这对于判断肝损伤程度有一定作用。本文综述胆汁酸的毒性作用与胆道闭锁病理生理变化之间的相关性,并简要介绍目前胆道闭锁诊断与治疗过程中与胆汁酸密切关联的方案与措施,为临床及研究工作提供参考。
- Abstract:
- Biliary atresia,as the main component of bile,have physiological functions such as digesting lipids,regulating gut microbiota,and controlling metabolism.Children with biliary atresia often experience varying degrees of bile acid metabolism disorders.Bile acids are amphiphilic molecules,with hydrophobic bile acids generally exhibiting higher cytotoxicity.In the pathological state of biliary atresia,the inherent cytotoxicity of bile acid is amplified,contributing to a series of pathological changes.Conversely,hydrophilic bile acids,such as ursodeoxycholic acid,can significantly improve liver function,a characteristic currently used in the treatment of biliary atresia.Serum bile acid levels increase with the severity of liver fibrosis,which can be useful for assessing the extent of liver damage.This article reviews the relationship between the toxic effects of bile acids and the pathophysiological changes in biliary atresia,and briefly introduces current diagnostic and therapeutic approaches related to bile acids in the management of biliary atresia,providing references for clinical and research work.
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备注/Memo
收稿日期:2022-8-25。
基金项目:国家中心自主设计项目(S20C0004)
通讯作者:钭金法,Email:toujinfa@zju.edu.cn