Ailiyaer·Keyimu,Aliyaguli·Abudoureyimu,Wu Zukai,et al.Analysis of theraperutic effects of different surgicul metheods for patent ductus arteriosus[J].Journal of Clinical Pediatric Surgery,2024,(02):173-177.[doi:10.3760/cma.j.cn101785-202209055-014]
不同手术方式治疗动脉导管未闭的疗效分析
- Title:
- Analysis of theraperutic effects of different surgicul metheods for patent ductus arteriosus
- Keywords:
- Ductus Arteriosus; Patent; Surgical Procedures; Operative; Treatment Outcome
- 摘要:
- 目的 探讨传统左后外侧切口动脉导管结扎术、电视胸腔镜下动脉导管结扎术、改良腋下小切口动脉导管结扎术治疗动脉导管未闭(patent ductus arteriosus,PDA)的疗效。方法 回顾性分析2018年2月至2020年12月新疆医科大学第一附属医院小儿心胸外科收治的PDA患儿临床资料,根据手术方式分为A、B、C三组,A组采取传统经左后外侧切口动脉导管结扎术,B组采取电视胸腔镜下动脉导管结扎术,C组采取改良腋下小切口动脉导管结扎术。本研究纳入PDA患儿119例,其中A组41例(男16例,女25例)、B组37例(男19例,女18例)、C组41例(男17例,女24例)。比较三组患儿手术时间、术中出血量、切口长度、术后胸腔闭式引流量、重症监护室(Intensive Care Unit,ICU)滞留时间、胸腔闭式引流时间、术后住院时间及并发症发生率。结果 A、B、C三组患儿手术时间[(112.20±26.41)min、(104.51±18.59)min、(114.39±33.28)min]差异无统计学意义(P>0.05)。A、B两组术后留置胸腔闭式引流管,B组术后胸腔引流量少于A组[(69.05±23.95)mL比(109.76±37.18)mL],引流时间短于A组[(3.24±0.93)d比(4.66±2.67)d],差异均有统计学意义(P<0.05);C组未留置胸腔闭式引流管。在切口长度、术中出血量、术后住院时间、ICU滞留时间及气管插管时间上比较,B组均短于或少于A组,C组均短于或少于B组,差异均有统计学意义(P<0.05)。患儿返回病房后1 h、12 h、24 h的FLACC疼痛评分比较,A组均高于B组,B组均高于C组,差异均有统计学意义(P<0.05)。三组术后均无一例残余分流、乳糜胸发生;C组出现少量胸腔积液1例,轻度气胸1例;A组出现肺不张4例,肺部感染5例;B组出现肺不张5例,肺部感染5例;A、B两组并发症发生率均高于C组,差异均有统计学意义(P<0.05)。结论 腋下小切口动脉导管结扎术治疗PDA创伤小,恢复快,美容效果好,并发症少,可作为临床首选方法之一。
- Abstract:
- Objective To explore the efficacy of traditional ligation of patent ductus arteriosus (PDA) through left posterolateral incision,video-assisted thoracoscopic closure of PDA and modified ligation of PDA through axillary small incision.Methods From February 2018 to December 2020,clinical data were retrospectively reviewed for 119 PDA children.According to different surgical approaches,they were divided into three groups of A,B and C.Group A underwent traditional ligation of PDA through left posterolateral incision,group B video-assisted thoracoscopic closure of PDA and group C modified axillary small incision ligation of PDA.Operative duration,volume of blood loss,incision length,postoperative closed chest drainage volume,ICU retention time,closed chest drainage removal time,postoperative hospitalization stay and incidence of complications were recorded.Results There were 16 boys and 25 girls in group A,19 boys and 18 girls in group B and 17 boys and 24 girls in group C.Among groups A,B and C,no statistical differences existed in operative duration (112.20±26.41,104.51±18.59,114.39±33.28 min) or complications (9,10,2)(P>0.05):volume of blood loss (18.12±13.69,11.73±9.15,10.68±7.08 ml),incision length (8.98±0.94,4.05±0.48,2.38±0.31 cm),volume of closed chest drainage (109.76±37.18,69.05±23.95),removal time of closed chest drainage (4.66±2.67、3.24±0.93 day).No closed chest irrigation in group c.Tracheal intubation time (7.68±1.77,6.81±2.38,5.66±1.51 h),ICU retention time (42.78±21.62,39.94±14.48,29.39±12.94 h),postoperative hospitalization stay (6.17±1.80,5.54±1.92,4.56±0.92 day),FLACC score (facial expression,legs,activity,cry & consolability) T1 (6.63±0.70,5.97±0.93,4.73±1.03),T2 (5.66±0.83,5.19±0.81,3.20±0.98),T3 (5.07±0.75,4.51±0.84,2.83±1.09).Group B was less than group A and group C less than group B.The differences were statistically significant (P<0.05).Conclusions Small axillary incision ligation of PDA is preferred due to minimal trauma,quicker recovery,excellent cosmetics and fewer complications.
参考文献/References:
[1] Sudhakar P,Jose J,George OK.Contemporary outcomes of percutaneous closure of patent ductus arteriosus in adolescents and adults[J].Indian Heart J,2018,70(2):308-315.DOI:10.1016/j.ihj.2017.08.001.
[2] Crockett SL,Berger CD,Shelton EL,et al.Molecular and mechanical factors contributing to ductus arteriosus patency and closure[J].Congenit Heart Dis,2019,14(1):15-20.DOI:10.1111/chd.12714.
[3] Gillam-Krakauer M,Reese J.Diagnosis and management of patent ductus arteriosus[J].Neoreviews,2018,19(7):e394-e402.DOI:10.1542/neo.19-7-e394.
[4] Stankowski T,Aboul-Hassan SS,Seifi-Zinab F,et al.Descriptive review of patent ductus arteriosus ligation by video-assisted thoracoscopy in pediatric population:7-year experience[J].J Thorac Dis,2019,11(6):2555-2563.DOI:10.21037/jtd.2019.05.59.
[5] Stankowski T,Aboul-Hassan SS,Fritzsche D,et al.Conversion to thoracotomy of video-assisted thoracoscopic closure of patent ductus arteriosus[J].Kardiochir Torakochirurgia Pol,2018,15(2):102-106.DOI:10.5114/kitp.2018.76475.
[6] 张耀之,李泉,刘琴湘.帕瑞昔布钠与曲马多超前镇痛在小儿腹腔镜疝修补术中的应用[J].临床小儿外科杂志,2014,13(3):250-252.DOI:10.3969/j.issn.1671-6353.2014.03.024.Zhang YZ,Li Q,Liu QX.Effect of preemptive analgesia with Parecoxib sodium and tramadol in children during hernia laparoscopy[J].J Clin Ped Sur,2014,13(3):250-252.DOI:10.3969/j.issn.1671-6353.2014.03.024.
[7] Yamada S,Terzic A.Path toward proactive therapy for patent ductus arteriosus[J].Clin Pharmacol Ther,2019,106(6):1187-1190.DOI:10.1002/cpt.1583.
[8] Abdel-Bary M,Abdel-Baseer KA,Abdel-Latif AF,et al.Left ventricular dysfunction postsurgical patent ductus arteriosus ligation in children:predictor factors analysis[J].J Cardiothorac Surg,2019,14(1):168.DOI:10.1186/s13019-019-0990-z.
[9] Okulu E,Erdeve O,Arslan Z,et al.An observational,prospective,multicenter,registry-based cohort study comparing conservative and medical management for patent ductus arteriosus[J].Front Pediatr,2020,8:434.DOI:10.3389/fped.2020.00434.
[10] 刘媛媛,包敏,张明明,等.X线下联合经胸超声心动图经皮单根血管入径介入封堵治疗动脉导管未闭的临床研究[J].中国介入心脏病学杂志,2021,29(1):15-18.DOI:10.3969/j.issn.1004-8812.2021.01.004.Liu YY,Bao M,Zhang MM,et al.Clinical trial of percutaneous occlusion with single vascular approach of patent ductus arteriosus by radiography plus transthoracic echocardiography[J].Chin J Interv Cardiol,2021,29(1):15-18.DOI:10.3969/j.issn.1004-8812.2021.01.004.
[11] 郭利敏,马进,陈名武.对乙酰氨基酚和布洛芬治疗不同胎龄阶段早产儿动脉导管未闭的对照研究[J].中华全科医学,2021,19(2):248-251.DOI:10.16766/j.cnki.issn.1674-4152.001779.Guo LM,Ma J,Chen MW.A comparative study of paracetamol versus ibuprofen on patent ductus arteriosus in preterm infants at different gestational ages[J].Chin J Gen Pract,2021,19(2):248-251.DOI:10.16766/j.cnki.issn.1674-4152.001779.
[12] Liu AJ,Yang M,Fan XM,et al.Application of left axillary incision in patent ductus arteriosus ligation[J].Heart Surg Forum,2021,24(1):E055-E059.DOI:10.1532/hsf.3419.
[13] Reese J,Scott TA,Patrick SW.Changing patterns of patent ductus arteriosus surgical ligation in the United States[J].Semin Perinatol,2018,42(4):253-261.DOI:10.1053/j.semperi.2018.05.008.
[14] Pradegan N,Mu?oz YM,Vida VL,et al.Extrapleural closure of patent ductus arteriosus:how we do it[J].Braz J Cardiovasc Surg,2020,35(5):831-833.DOI:10.21470/1678-9741-2019-0473.
相似文献/References:
[1]杜朝峻,丁力,胡英超,等.手术治疗婴幼儿法洛四联症83例[J].临床小儿外科杂志,2010,9(06):413.
DU Chao jun,DING Li,HU Ying chao,et al.Surgical treatment of Tetralogy of Fallot in infancy: Experiences of 83 cases.[J].Journal of Clinical Pediatric Surgery,2010,9(02):413.
[2]李勇,尹强,周小渔,等.术中胆道造影在先天性胆总管囊肿手术中的应用[J].临床小儿外科杂志,2010,9(06):430.
LI Yong,YIN Qiang,ZHOU Xiao yu,et al.The clinic application experience on intraoperative cholangiography in pediatric surgery.[J].Journal of Clinical Pediatric Surgery,2010,9(02):430.
[3]许芝林,王强,李琰,等.乙状结肠冗长症的术式选择探讨[J].临床小儿外科杂志,2010,9(06):432.
XU Zhi lin,WANG Qiang,LI Yan,et al.Initiatory exploration of the standard of surgical treatment methods for Dolichosigmoid.[J].Journal of Clinical Pediatric Surgery,2010,9(02):432.
[4]常绘文,沈振亚.右腋下小切口在儿童心内手术中的应用[J].临床小儿外科杂志,2010,9(06):439.
[5]胡明,施诚仁,严志龙.脐环小切口治疗婴幼儿腹盆腔疾病的探讨[J].临床小儿外科杂志,2010,9(06):471.
[6]丁勇,魏华,孔燕,等.横裁包皮岛状皮瓣法在尿道下裂治疗中的应用[J].临床小儿外科杂志,2010,9(06):474.
[7]江峰赵阳孙莲萍金惠明马杰.婴幼儿阻塞性脑积水两种手术方式的疗效比较[J].临床小儿外科杂志,2011,10(01):0.
JIANG Feng,ZHAO Yang,SUN Liang ping,et al.Endoscopic third ventricul ostomy versus ventricul operitoneal shunt:clinical study of obstructive hydro cephalus in infants.[J].Journal of Clinical Pediatric Surgery,2011,10(02):0.
[8]王伟程少文彭磊林忠勤张伟陈庆玉寇冬权.弹性髓内钉在儿童肱骨骨折中的应用[J].临床小儿外科杂志,2011,10(01):0.
WANG Wei,CHENG Shaowen,PENG Lei,et al.Application of elastic intramedullary nailing in pediatric humeral fractures.[J].Journal of Clinical Pediatric Surgery,2011,10(02):0.
[9]景登攀张根领孙蔓丽.改良Snodgrass术治疗尿道下裂疗效观察[J].临床小儿外科杂志,2011,10(01):0.
[10]陈快 黄金狮 戴康临 陶俊峰 赖勇强 陶强. 腹腔镜与开腹Ladd手术治疗新生儿肠旋转不良效果比较[J].临床小儿外科杂志,2011,10(02):128.
[J].Journal of Clinical Pediatric Surgery,2011,10(02):128.
备注/Memo
收稿日期:2022-9-30。
基金项目:2021年自治区科技计划项目(2021D01C329)
通讯作者:张国明,Email: 406765929@qq.com