Li Hui,Shi Dongliang,Ni Xiaoyan,et al.Denosumab treatment of pelvic aneurysmal bone cyst in children:one case report with a literature review[J].Journal of Clinical Pediatric Surgery,2023,22(11):1086-1088.[doi:10.3760/cma.j.cn101785-202203037-016]
地舒单抗治疗儿童骨盆动脉瘤样骨囊肿1例及文献复习
- Title:
- Denosumab treatment of pelvic aneurysmal bone cyst in children:one case report with a literature review
- 摘要:
- 动脉瘤样骨囊肿是一种具有膨胀性和破坏性生长特征的骨良性肿瘤,好发于青少年,肿瘤细胞内核因子-κB受体活化因子配体(receptor activator of nuclear factor kappa-B ligand,RANKL)表达丰富。盆腔动脉瘤样骨囊肿较为少见,部位特殊,手术风险大,容易复发,如不及时治疗,往往容易出现病理性骨折。地舒单抗是针对RANKL的全人源化单克隆抗体,为治疗难治性动脉瘤样骨囊肿提供了新思路。本文报道1例12岁原发性骨盆动脉瘤样骨囊肿患者,予地舒单抗治疗后临床症状改善,其间出现低钙血症及生长板钙化现象。
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备注/Memo
收稿日期:2022-3-11。
基金项目:国家自然科学基金(82072552)
通讯作者:李会,Email:eric.li@jiahui.com