Tan Qian,Liu Yaoxi,Yi Yinzhi,et al.Treatment of congenital pseudarthrosis of the tibia with proximal tibial epiphyseal plate extension and subphyseal plate extension[J].Journal of Clinical Pediatric Surgery,2023,22(11):1055-1059.[doi:10.3760/cma.j.cn101785-202303055-010]
胫骨近端骺板延长和骺板下延长治疗先天性胫骨假关节胫骨短缩的临床研究
- Title:
- Treatment of congenital pseudarthrosis of the tibia with proximal tibial epiphyseal plate extension and subphyseal plate extension
- Keywords:
- Tibia; Bone Lengthening; Growth Plate; Surgical Procedures; Operative; Child
- 摘要:
- 目的 评估儿童先天性胫骨假关节(congenital pseudarthrosis of the tibia,CPT)患者使用伊氏外固定装置行胫骨近端骺板下延长术和胫骨近端骺板延长术的愈合及并发症情况。方法 回顾性分析湖南省儿童医院2012年2月至2020年6月间使用伊氏外固定装置行胫骨延长手术的61例CPT患儿临床资料。根据手术方式分组,行胫骨近端骺板下延长术者为A组(n=54),行胫骨近端骺板延长术者为B组(n=7)。选取延长后第1个月的X线片检查结果,采用Li分型评估骨痂质量。随访延长段骨痂质量及胫骨延长术后并发症情况。结果 A组与B组手术时年龄[(87.0±5.9)个月比(115.2±15.2)个月]、延长长度[(5.3±0.2)cm比(7.0±1.6)cm]、愈合指数[(57.3±3.6)d/cm比(50.4±7.4)d/cm]比较,差异均无统计学意义(P>0.05);两组骨痂质量良好率(37/54比7/7)比较,差异无统计学意义(P=0.088);两组并发症发生率比较,针道感染(4/54比1/7)、胫骨机械轴线偏移(4/54比1/7)、腓骨提前愈合(3/54比0/7)、踝关节僵硬(2/54比1/7)、膝关节活动范围减小(7/54比1/7)的差异均无统计学意义(P>0.05)。结论 胫骨近端骺板延长术与胫骨近端骺板下延长术均为CPT伴胫骨短缩的有效治疗方法,但胫骨近端骺板下延长存在腓骨提前愈合等并发症。
- Abstract:
- Objective To evaluate the healing status and complications of proximal tibial epiphyseal plate lengthening using Ilizarov external fixation device in children with congenital pseudarthrosis of the tibia (CPT).Methods Retrospective analysis was conducted for clinical data of 61 CPT children undergoing tibial lengthening surgery using Ilizarov external fixation device from February 2012 to June 2020.According to surgical method,they were assigned into two groups of A and B.Radiographic examination results of the first month after extension were utilized for evaluating the quality of bone callus by the Li classification scheme.Follow-ups were conducted for the quality of bone callus in extended segment and postoperative complications.Results No statistically significant inter-group difference (P>0.05) existed in operative age[(87.0±5.9) vs.(115.2±15.2) month],length of extension[(5.3±0.2) vs.(7.0±1.6) cm]or healing index[(57.3±3.6) vs.(50.4±7.4) d/cm].There was no statistically significant inter-group difference (P>0.05) in rate of good callus quality (37/54 vs.7/7).No statistically significant inter-group difference (P=0.088) existed in the incidence of complications or needle infection (4/54 vs.1/7).No statistically significant differences existed (P>0.05) in deviation of tibial mechanical axis (4/54 vs.1/7),early healing of fibula (3/54 vs.0/7),ankle Joint stiffness (2/54 vs.1/7) or reduction of knee range of motion (7/54 vs.1/7).Conclusions Both proximal tibial epiphyseal plate elongation and proximal tibial epiphyseal plate elongation are efficacious for CPT.And early fibular healing may occur in the extension of proximal tibial epiphyseal plate.
参考文献/References:
[1] 刘尧喜,张学军,郭跃明,等.儿童先天性胫骨假关节行不同术式疗效的多中心临床研究[J].中华小儿外科杂志,2020,41(10):933-937.DOI:10.3760/cma.j.n421158-20200520-00355. Liu YX,Zhang XJ,Guo YM,et al.A multicenter clinical trial on the efficacy of different surgical approaches for congenital pseudarthrosis of tibia in children[J].Chin J Pediatr Surg,2020,41(10):933-937.DOI:10.3760/cma.j.cn421158-20200520-00355.
[2] 刘尧喜,刘昆,伍江雁,等.克氏针髓内固定治疗一岁以内先天性胫骨假关节的临床研究[J].中华小儿外科杂志,2019,40(10):930-934.DOI:10.3760/cma.j.issn.0253-3006.2019.10.013. Liu YX,Liu K,Wu JY,et al.Preliminary outcomes of intramedullary fixation of Kirschner’s wire for congenital pseudarthrosis of tibia in children aged under 1 year[J].Chin J Pediatr Surg,2019,40(10):930-934.DOI:10.3760/cma.j.issn.0253-3006.2019.10.013.
[3] Liu YX,Yang G,Liu K,et al.Combined surgery with 3-in-1 osteosynthesis in congenital pseudarthrosis of the tibia with intact fibula[J].Orphanet J Rare Dis,2020,15(1):62.DOI:10.1186/s13023-020-1330-z.
[4] Liu YX,Mei HB,Zhu GH,et al.Congenital pseudarthrosis of the tibia in children:should we defer surgery until 3 years old?[J].J Pediatr Orthop B,2018,27(1):17-25.DOI:10.1097/BPB.0000000000000468.
[5] Rozbruch SR,Kleinman D,Fragomen AT,et al.Limb lengthening and then insertion of an intramedullary nail:a case-matched comparison[J].Clin Orthop Relat Res,2008,466(12):2923-2932.DOI:10.1007/s11999-008-0509-8.
[6] Ilizarov GA.The tension-stress effect on the genesis and growth of tissues:part I.The influence of stability of fixation and soft-tissue preservation[J].Clin Orthop Relat Res,1989,238:249-281.
[7] Li R,Saleh M,Yang L,et al.Radiographic classification of osteogenesis during bone distraction[J].J Orthop Res,2006,24(3):339-347.DOI:10.1002/jor.20026.
[8] Cho TJ,Choi IH,Lee KS,et al.Proximal tibial lengthening by distraction osteogenesis in congenital pseudarthrosis of the tibia[J].J Pediatr Orthop,2007,27(8):915-920.DOI:10.1097/bpo.0b013e31815a6058.
[9] Jang WY,Choi YH,Park MS,et al.Physeal and subphyseal distraction osteogenesis in atrophic-type congenital pseudarthrosis of the tibia:efficacy and safety[J].J Pediatr Orthop,2019,39(8):422-428.DOI:10.1097/BPO.0000000000000979.
[10] Zhu GH,Mei HB,He RG,et al.Effect of distraction osteogenesis in patient with tibial shortening after initial union of Congenital Pseudarthrosis of the Tibia (CPT):a preliminary study[J].BMC Musculoskelet Disord,2015,16:216.DOI:10.1186/s12891-015-0680-5.
[11] Balci H[KG-1.6mm]I[DD(-*3][HT7.]·[HT6],Bayram S,Pehlivanoglu T,et al.Effect of lengthening speed on the quality of callus and complications in patients with congenital pseudarthrosis of tibia[J].Int Orthop,2021,45(6):1517-1522.DOI:10.1007/s00264-021-05011-7.
[12] Ring PA.Experimental bone lengthening by epiphysial distraction[J].Br J Surg,1958,46(196):169-173.DOI:10.1002/bjs.18004619617.
[13] Hamanishi C,Tanaka S,Tamura K.Early physeal closure after femoral chondrodiatasis.Loss of length gain in 5 cases[J].Acta Orthop Scand,1992,63(2):146-149.DOI:10.3109/17453679209154810.
[14] Vlad C,Gavriliu TS,Georgescu I,et al.Bone transport with the lengthening through the physis in patients having congenital pseudarthrosis of tibia-short-term results[J].J Med Life,2013,6(3):266-271.
[15] Donnan LT,Gomes B,Donnan A,et al.Ilizarov tibial lengthening in the skeletally immature patient[J].Bone Joint J,2016,98-B(9):1276-1282.DOI:10.1302/0301-620X.98B10.37523.
[16] Monticelli G,Spinelli R.Distraction epiphysiolysis as a method of limb lengthening.Ⅲ.Clinical applications[J].Clin Orthop Relat Res,1981,154:274-285.DOI:10.1097/00003086-198101000-00041.
[17] Ilizarov GA,Soǐbel’man LM.Clinical and experimental data on bloodless lengthening of lower extremities[J].Eksp Khir Anesteziol,1969,14(4):27-32.
[18] Alberty A,Peltonen J,Ritsil? V.Distraction effects on the physis in rabbits[J].Acta Orthop Scand,1990,61(3):258-262.DOI:10.3109/17453679008993513.
相似文献/References:
[1]梅海波. 包裹式自体髂骨移植治疗儿童先天性胫骨假关节的疗效观察[J].临床小儿外科杂志,2011,10(03):163.
[2]刘尧喜,谭谦,刘昆,等.新型可延伸髓内棒治疗儿童先天性胫骨假关节的临床研究[J].临床小儿外科杂志,2022,21(10):953.[doi:10.3760/cma.j.cn101785-202105042-010]
Liu Yaoxi,Tan Qian,Liu Kun,et al.Application of "telescopic rod" in combined surgical technique for the treatment of congenital pseudarthrosis of the tibia in children[J].Journal of Clinical Pediatric Surgery,2022,21(11):953.[doi:10.3760/cma.j.cn101785-202105042-010]
[3]俞辉,李卓扬,易银芝,等.先天性胫骨假关节的文献计量学分析[J].临床小儿外科杂志,2022,21(11):1049.[doi:10.3760/cma.j.cn101785-202202041-010]
Yu Hui,Li Zhuoyang,Yi Yinzhi,et al.Top 100 classic research papers of congenital pseudarthrosis of the tibia: a bibliometric analysis[J].Journal of Clinical Pediatric Surgery,2022,21(11):1049.[doi:10.3760/cma.j.cn101785-202202041-010]
[4]肖汉,朱光辉,梅海波,等.半骨骺阻滞术治疗儿童先天性胫骨假关节愈合后胫骨近端外翻的疗效评价[J].临床小儿外科杂志,2022,21(12):1141.[doi:10.3760/cma.j.cn101785-202204026-008]
Xiao Han,Zhu Guanghui,Mei Haibo,et al.Evaluations of hemiepiphysiodesis for proximal tibial valgus after initial union of congenital pseudarthrosis of the tibia in children[J].Journal of Clinical Pediatric Surgery,2022,21(11):1141.[doi:10.3760/cma.j.cn101785-202204026-008]
[5]王兰英,谢鑑辉,侯姝婷,等.先天性胫骨假关节患儿照顾者应激相关性成长现状及影响因素分析[J].临床小儿外科杂志,2024,(01):77.[doi:10.3760/cma.j.cn101785-202306001-015]
Wang Lanying,Xie Jianhui,Hou Shuting,et al.Analysis of stress related growth status and influencing factors in caregivers of children with congenital tibial pseudarthrosis[J].Journal of Clinical Pediatric Surgery,2024,(11):77.[doi:10.3760/cma.j.cn101785-202306001-015]
[6]刘尧喜,伍江雁,杨戈,等.儿童先天性胫骨假关节行胫骨近端延长的临床疗效评价[J].临床小儿外科杂志,2024,(02):147.[doi:10.3760/cma.j.cn101785-202204086-009]
Liu Yaoxi,Wu Jiangyan,Yang Ge,et al.Clinical evaluation of proximal tibial extension in children with congenital pseudarthrosis of the tibia[J].Journal of Clinical Pediatric Surgery,2024,(11):147.[doi:10.3760/cma.j.cn101785-202204086-009]
备注/Memo
收稿日期:2023-3-25。
基金项目:湖南省卫生健康委一般指导课题(D202304078395); 湖南省自然科学基金青年基金(2021JJ40271); 国家临床重点专科建设项目-湖南省儿童医院儿外科(湘卫医发[2022]2号); 湖南省科卫联合基金(2022JJ70007); 湖南省科卫联合基金(2021JJ70081); 湖南省临床医疗技术创新引导项目(2021SK50526); 儿童骨科学湖南省重点实验室
通讯作者:梅海波,Email:meihaiboprofe@outlook.c