[1]莫绪明,笪敏.中国儿童胸部实体肿瘤诊疗现状[J].临床小儿外科杂志,2022,21(03):201-207.[doi:10.3760/cma.j.cn101785-202202029-001]
　Mo Xuming,Da Min.Current status of diagnosing and treating thoracic solid tumors in Chinese children[J].Journal of Clinical Pediatric Surgery,2022,21(03):201-207.[doi:10.3760/cma.j.cn101785-202202029-001]
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中国儿童胸部实体肿瘤诊疗现状

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第21卷 期数: 2022年03期 页码: 201-207 栏目: 述评 出版日期: 2022-03-28
Title:
Current status of diagnosing and treating thoracic solid tumors in Chinese children
作者:
莫绪明;  笪敏
南京医科大学附属儿童医院心胸外科, 南京 210000
Author(s):
Mo Xuming;  Da Min
Department of Cardiothoracic Surgery, Children’s Hospital Affiliated to Nanjing Medical University, Nanjing 210000, China
关键词:
胸部肿瘤/诊断; 胸部肿瘤/治疗; 胸部肿瘤/外科学; 实体肿瘤疗效评价标准; 儿童
Keywords:
Thoracic Neoplasms/DI; Thoracic Neoplasms/TH; Thoracic Neoplasms/SU; Response Evaluation Criteria in Solid Tumors; Child
DOI:
10.3760/cma.j.cn101785-202202029-001
摘要:
儿童胸部实体肿瘤发病率较低。不管是国际还是国内，每年针对该类肿瘤进行的研究报道数量均相对较少。本文以近年开展的儿童胸部实体肿瘤临床研究为基础，对常见的胸壁肿瘤、肺与支气管肿瘤及纵隔肿瘤的诊治进展进行述评，并分析我国儿童胸部实体肿瘤诊疗流程中存在的不足，提出解决方案和建议，为小儿胸外科临床医师诊治该类疾病提供参考。
Abstract:
The incidence of solid thoracic tumors is low in children.Relatively few international and domestic studies are conducted for this rare type of tumors.This review summarized the latest diagnostic and therapeutic advances of common chest wall tumors, lung and bronchial tumors and mediastinal tumors.The shortcomings of domestic institutions and treatment protocols for solid thoracic tumors in children were discussed and corrective recommendations proposed as a clinical reference for practitioners in this field.

参考文献/References:

[1] Pusiol T, Piscioli I, Scialpi M, et al.Giant benign solitary fibrous tumour of the pleura (>15 cm):role of radiological pathological correlations in management.Report of 3 cases and review of the literature[J].Pathologica, 2013, 105(3):77-82.
[2] Guo N, Yu C, Liu Y, et al.Analysis of 50 cases of operated giant thoracic tumors[J].J BUON, 2015, 20(5):1360-1367.
[3] 叶木杰, 柳龚堡, 董岿然.CAR-T细胞免疫靶向治疗在儿童恶性肿瘤中的应用进展[J].中华小儿外科杂志, 2019, 40(4):370-373.DOI:10.3760/cma.j.issn.0253-3006.2019.04.017.Ye MJ, Liu GB, Dong KR.Advances of CAR-T cell immunotherapeutic targeting for malignant tumors of children[J].Chinese Journal of Pediatric Surgery, 2019, 40(4):370-373.DOI:10.3760/cma.j.issn.0253-3006.2019.04.017.
[4] 肖卉.神经母细胞瘤肿瘤微环境和免疫治疗的研究进展[J].国际儿科学杂志, 2021, 48(7):435-439.DOI:10.3760/cma.j.issn.1673-4408.2021.07.001. Xiao Hui.Tumor microenvironment and immunotherapy of neuroblastoma[J].International Journal of Pediatrics, 2021, 48(7):435-439.DOI:10.3760/cma.j.issn.1673-4408.2021.07.001.
[5] La Quaglia MP.Chest wall tumors in childhood and adolescence[J].Semin Pediatr Surg, 2008, 17(3):173-180.DOI:10.1053/j.sempedsurg.2008.03.007.
[6] Cipriano A, Burfeind W, Jr.Management of primary soft tissue tumors of the chest wall[J].Thorac Surg Clin, 2017, 27(2):139-147.DOI:10.1016/j.thorsurg.2017.01.007.
[7] Van Den Berg H, Van Rijn RR, Merks JH.Management of tumors of the chest wall in childhood:a review[J].J Pediatr Hematol Oncol, 2008, 30(3):214-221.DOI:10.1097/MPH.0b013e318162bd54.
[8] Ito T, Suzuki H, Yoshino I.Mini review:surgical management of primary chest wall tumors[J].Gen Thorac Cardiovasc Surg, 2016, 64(12):707-714.DOI:10.1007/s11748-016-0719-z.
[9] Grunewald TGP, Cidre-Aranaz F, Surdez D, et al.Ewing sarcoma[J].Nat Rev Dis Primers, 2018, 4(1):5.DOI:10.1038/s41572-018-0003-x.
[10] Gargallo P, Juan A, Yanez Y, et al.Precision medicine in Ewing sarcoma:a translational point of view[J].Clin Transl Oncol, 2020, 22(9):1440-1454.DOI:10.1007/s12094-020-02298-7.
[11] Yu H, Ge Y, Guo L, et al.Potential approaches to the treatment of Ewing’s sarcoma[J].Oncotarget, 2017, 8(3):5523-5539.DOI:10.18632/oncotarget.12566.
[12] Flores G, Grohar PJ.One oncogene, several vulnerabilities:EWS/FLI targeted therapies for Ewing sarcoma[J].J Bone Oncol, 2021, 31:100404.DOI:10.1016/j.jbo.2021.100404.
[13] Yohe ME, Heske CM, Stewart E, et al.Insights into pediatric rhabdomyosarcoma research:Challenges and goals[J].Pediatr Blood Cancer, 2019, 66(10):e27869.DOI:10.1002/pbc.27869.
[14] Leiner J, Le Loarer F.The current landscape of rhabdomyosarcomas:an update[J].Virchows Arch, 2020, 476(1):97-108.DOI:10.1007/s00428-019-02676-9.
[15] Mandeville HC.Radiotherapy in the management of childhood rhabdomyosarcoma[J].Clin Oncol (R Coll Radiol), 2019, 31(7):462-470.DOI:10.1016/j.clon.2019.03.047.
[16] Rogers TN, Dasgupta R.Management of rhabdomyosarcoma in pediatric patients[J].Surg Oncol Clin N Am, 2021, 30(2):339-353.DOI:10.1016/j.soc.2020.11.003.
[17] Skapek SX, Ferrari A, Gupta AA, et al.Rhabdomyosarcoma[J].Nat Rev Dis Primers, 2019, 5(1):1.DOI:10.1038/s41572-018-0051-2.
[18] Lichtenberger JP 3rd, Biko DM, Carter BW, et al.Primary lung tumors in children:radiologic-pathologic correlation from the Radiologic Pathology Archives[J].Radiographics, 2018, 38(7):2151-2172.DOI:10.1148/rg.2018180192.
[19] Weldon CB, Shamberger RC.Pediatric pulmonary tumors:primary and metastatic[J].Semin Pediatr Surg, 2008, 17(1):17-29.DOI:10.1053/j.sempedsurg.2007.10.004.
[20] Zapala MA, Ho-Fung VM, Lee EY.Thoracic neoplasms in children:contemporary perspectives and imaging assessment[J].Radiol Clin North Am, 2017, 55(4):657-676.DOI:10.1016/j.rcl.2017.02.008.
[21] Mahajan P, Casanova M, Ferrari A, et al.Inflammatory myofibroblastic tumor:molecular landscape, targeted therapeutics, and remaining challenges[J].Curr Probl Cancer, 2021, 45(4):100768.DOI:10.1016/j.currproblcancer.2021.100768.
[22] Casanova M, Brennan B, Alaggio R, et al.Inflammatory myofibroblastic tumor:the experience of the european pediatric soft tissue sarcoma study group (EpSSG)[J].Eur J Cancer, 2020, 127:123-129.DOI:10.1016/j.ejca.2019.12.021.
[23] Butrynski JE, D’adamo DR, Hornick JL, et al.Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor[J].N Engl J Med, 2010, 363(18):1727-1733.DOI:10.1056/NEJMoa1007056.
[24] Mosse YP, Voss SD, Lim MS, et al.Targeting ALK with crizotinib in pediatric anaplastic large cell lymphoma and inflammatory myofibroblastic tumor:A Children’s Oncology Group Study[J].J Clin Oncol, 2017, 35(28):3215-3221.DOI:10.1200/jco.2017.73.4830.
[25] Borczuk AC.Pulmonary neuroendocrine tumors[J].Surg Pathol Clin, 2020, 13(1):35-55.DOI:10.1016/j.path.2019.10.002.
[26] Rojas Y, Shi YX, Zhang W, et al.Primary malignant pulmonary tumors in children:a review of the national cancer data base[J].J Pediatr Surg, 2015, 50(6):1004-1008.DOI:10.1016/j.jpedsurg.2015.03.032.
[27] Petursdottir A, Sigurdardottir J, Fridriksson BM, et al.Pulmonary carcinoid tumours:incidence, histology and surgical outcome:a population-based study[J].Gen Thorac Cardiovasc Surg, 2020, 68(5):523-529.DOI:10.1007/s11748-019-01261-w.
[28] Caplin ME, Baudin E, Ferolla P, et al.Pulmonary neuroendocrine (carcinoid) tumors:european neuroendocrine tumor society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids[J].Ann Oncol, 2015, 26(8):1604-1620.DOI:10.1093/annonc/mdv041.
[29] Melosky B.Advanced typical and atypical carcinoid tumours of the lung:management recommendations[J].Curr Oncol, 2018, 25(Suppl 1):S86-S93.DOI:10.3747/co.25.3808.
[30] Kalhor N, Moran CA.Pulmonary mucoepidermoid carcinoma:diagnosis and treatment[J].Expert Rev Respir Med, 2018, 12(3):249-255.DOI:10.1080/17476348.2018.1428563.
[31] 张欣, 柏乾明, 姚茜岚, 等.原发性肺黏液表皮样癌MAML2基因重排、融合形式及临床病理学特征[J].中华病理学杂志, 2021, 50(8):891-898.DOI:10.3760/cma.j.cn.112151-20210421-00308.Zhang X, Bai QM, Yao QL, et al.MAML2 gene rearrangement, fusion patterns and clinicopathological characteristics in primary pulmonary mucoepidermoid carcinoma[J].Chinese Journal of Pathology, 2021, 50(8):891-898.DOI:10.3760/cma.j.cn.112151-20210421-00308.
[32] Li S, Zhang Z, Tang H, et al.Pathological complete response to gefitinib in a 10-year-old boy with EGFR-negative pulmonary mucoepidermoid carcinoma:a case report and literature review[J].Clin Respir J, 2017, 11(3):346-51.DOI:10.1111/crj.12343.
[33] Xi JJ, Jiang W, Lu SH, et al.Primary pulmonary mucoepidermoid carcinoma:an analysis of 21 cases[J].World J Surg Oncol, 2012, 10:232.DOI:10.1186/1477-7819-10-232.
[34] Dehner LP, Messinger YH, Schultz KA, et al.Pleuropulmonary Blastoma:Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome[J].Pediatr Dev Pathol, 2015, 18(6):504-511.DOI:10.2350/15-10-1732-oa.1.
[35] Mlika M, Anjum F, El Mezni F.Pleuropulmonary Blastoma[M].StatPearls.Treasure Island (FL).2021.
[36] Dishop MK, Kuruvilla S.Primary and metastatic lung tumors in the pediatric population:a review and 25-year experience at a large children’s hospital[J].Arch Pathol Lab Med, 2008, 132(7):1079-1103.DOI:10.5858/2008-132-1079-PAMLTI.
[37] Mon RA, Johnson KN, Ladino-Torres M, et al.Diagnostic accuracy of imaging studies in congenital lung malformations[J].Arch Dis Child Fetal Neonatal Ed, 2019, 104(4):F372-F377.DOI:10.1136/archdischild-2018-314979.
[38] Saez BJ, Pattillo SJ, Vuletin SJ.Pleuro-pulmonary blastoma presenting as a chest wall deformity:a case report[J].Rev Chil Pediatr, 2018, 89(2):231-235.DOI:10.4067/s0370-41062018000200231.
[39] Da M, Peng W, Mo X, et al.Comparison of efficacy between video-assisted thoracoscopic surgery and thoracotomy in children with mediastinal tumors:6-year experience[J].Ann Transl Med, 2019, 7(22):653.DOI:10.21037/atm.2019.10.81.
[40] Cohn SL, Pearson AD, London WB, et al.The international neuroblastoma risk group (INRG) classification system:an INRG task force report[J].J Clin Oncol, 2009, 27(2):289-97.DOI:10.1200/jco.2008.16.6785.
[41] Whittle SB, Smith V, Doherty E, et al.Overview and recent advances in the treatment of neuroblastoma[J].Expert Rev Anticancer Ther, 2017, 17(4):369-386.DOI:10.1080/14737140.2017.1285230.
[42] Zafar A, Wang W, Liu G, et al.Molecular targeting therapies for neuroblastoma:Progress and challenges[J].Med Res Rev, 2021, 41(2):961-1021.DOI:10.1002/med.21750.
[43] 左彤彤, 周卫萍.神经母细胞瘤的分子生物学特性和靶向药物临床研究进展[J].中国肿瘤临床, 2021, 48(8):426-431.DOI:10.3969/j.issn.1000-8179.2021.08.245.Zuo TT, Zhou WP.Research advances in molecular biology and targeted therapies of neuroblastoma[J].Chinese Journal of Clinical Oncology, 2021, 48(8):426-431.DOI:10.3969/j.issn.1000-8179.2021.08.245.
[44] Cairo MS, Beishuizen A.Childhood, adolescent and young adult non-Hodgkin lymphoma:current perspectives[J].Br J Haematol, 2019, 185(6):1021-1042.DOI:10.1111/bjh.15764.
[45] Mauz-Korholz C, Metzger ML, Kelly KM, et al.Pediatric Hodgkin Lymphoma[J].J Clin Oncol, 2015, 33(27):2975-2985.DOI:10.1200/jco.2014.59.4853.
[46] Mauz-Korholz C, Stroter N, Baumann J, et al.Pharmacotherapeutic management of pediatric lymphoma[J].Paediatr Drugs, 2018, 20(1):43-57.DOI:10.1007/s40272-017-0265-x.
[47] Mosbech CH, Rechnitzer C, Brok JS, et al.Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors[J].J Pediatr Hematol Oncol, 2014, 36(4):263-270.DOI:10.1097/mph.0000000000000125.
[48] Kim J, Lee NH, Lee SH, et al.Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy[J].Korean J Pediatr, 2015, 58(10):386-391.DOI:10.3345/kjp.2015.58.10.386.
[49] Rescorla FJ.Pediatric germ cell tumors[J].Semin Pediatr Surg, 2012, 21(1):51-60.DOI:10.1053/j.sempedsurg.2011.10.005.
[50] Shaikh F, Murray MJ, Amatruda JF, et al.Paediatric extracranial germ-cell tumours[J].Lancet Oncol, 2016, 17(4):e149-e162.DOI:10.1016/s1470-2045(15)00545-8.
[51] Weil BR, Billmire DF.Management of germ cell tumors in pediatric patients[J].Surg Oncol Clin N Am, 2021, 30(2):325-338.DOI:10.1016/j.soc.2020.11.011.
[52] Simonelli M, Rosti G, Banna GL, et al.Intensified chemotherapy with stem-cell rescue in germ-cell tumors[J].Ann Oncol, 2012, 23(4):815-822.DOI:10.1093/annonc/mdr403.

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备注/Memo

收稿日期:2022-02-13。
基金项目:国家自然科学基金面上项目（81970265）；省部共建临床医学研究中心培育计划项目（2019060007）
通讯作者:莫绪明,Email:mohsuming15@njmu.edu.cn

更新日期/Last Update: 1900-01-01