[1]张梅慧,姜大朋.先天性神经母细胞瘤发病机制与临床特点的研究进展[J].临床小儿外科杂志,2022,21(02):141-145.[doi:10.3760/cma.j.cn.101785-202105045-008]
　Zhang Meihui,Jiang Dapeng.Pathogenesis and clinical characteristics of congenital neuroblastoma[J].Journal of Clinical Pediatric Surgery,2022,21(02):141-145.[doi:10.3760/cma.j.cn.101785-202105045-008]
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先天性神经母细胞瘤发病机制与临床特点的研究进展

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第21卷 期数: 2022年02期 页码: 141-145 栏目: 专题·儿童神经母细胞瘤 出版日期: 2022-02-28
Title:
Pathogenesis and clinical characteristics of congenital neuroblastoma
作者:
张梅慧1;  姜大朋2
1 上海交通大学医学院, 上海 200025;
2 上海交通大学医学院附属上海儿童医学中心普外科, 上海 200127
Author(s):
Zhang Meihui1;  Jiang Dapeng2
1 Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
2 Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
关键词:
神经母细胞瘤/先天性; 神经母细胞瘤/病因学; 神经母细胞瘤/诊断
Keywords:
Neuroblastoma/CN; Neuroblastoma/ET; Neuroblastoma/DI
DOI:
10.3760/cma.j.cn.101785-202105045-008
摘要:
神经母细胞瘤是儿童最常见的颅外实体肿瘤，来源于肾上腺髓质或交感神经节。先天性神经母细胞瘤约占神经母细胞瘤患儿总数的5%，大多数患儿于出生后1个月内确诊。与1岁以上神经母细胞瘤患儿相比，新生儿神经母细胞瘤有其独特的病程。本文就先天性神经母细胞瘤的发病机制、临床表现、治疗方法以及预测患儿长期预后的生物学因素进行综述。
Abstract:
As the most common extracranial solid tumor in children, neuroblastoma originates from adrenal medulla or sympathetic ganglion.Congenital neuroblastoma accounts for 5% of all neuroblastomas and most patients are diagnosed within the first month after birth.Neonates have a unique disease course as compared to children aged over 1 year.This review summarized the pathogenesis and clinical presentations of congenital neuroblastoma, as well as biological factors of predicting the long-term prognosis of congenital neuroblastoma.

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备注/Memo

收稿日期:2021-05-24。
基金项目:国家临床重点专科项目资助
通讯作者:姜大朋,Email:jdp509@163.com

更新日期/Last Update: 1900-01-01