Hao Yajing,Chen Xiaolong,Cai Huaiqing,et al.Multiple arterial thrombosis in external iliac artery after thoracoscopic lobectomy in a boy with primary nephrotic syndrome-one case report and literature review[J].Journal of Clinical Pediatric Surgery,2022,21(01):93-96.[doi:10.3760/cma.j.cn.101785-202011020-018]
原发性肾病综合征胸腔镜肺叶切除术后多发血栓形成1例报告及文献复习
- Title:
- Multiple arterial thrombosis in external iliac artery after thoracoscopic lobectomy in a boy with primary nephrotic syndrome-one case report and literature review
- 摘要:
- 原发性肾病综合征主要表现为水肿、大量蛋白尿、低蛋白血症以及高脂血症。受脂质代谢紊乱、血液黏稠度增加、血容量减少等因素的影响,机体的凝血系统、抗纤溶系统失衡,血液处于高凝状态,容易并发血液栓塞性疾病,如不及时处理后果往往非常严重。本研究报道1例5岁原发性肾病综合征患儿,患儿因肺部感染入院,确诊为肺隔离症后行胸腔镜下肺叶切除术,术后50 h经血管B超诊断为髂外动脉多发血栓,后经积极溶栓治疗痊愈出院。本文总结本例治疗经验并复习相关文献,为肾病综合征患儿行胸腔镜手术的围手术期处理提供参考。
参考文献/References:
[1] 彭丽红,尹小文.糖皮质激素治疗肾病综合征并发重症肺炎的临床观察[J].临床合理用药杂志,2016,9(34):44-45.DOI:10.15887/j.cnki.13-1389/r.2016.34.025. Peng LH,Yin XW.Clinical observations of glucocorticoid therapy for nephrotic syndrome with severe pneumonia[J].Chinese Journal of Clinical Rational Drug Use,2016,9(34):44-45.DOI:10.15887/j.cnki.13-1389/r.2016.34.025.
[2] 刘彤.原发性肾病综合征合并高尿酸血症的血栓栓塞研究进展[J].国际泌尿系统杂志,2019,39(4):727-730.DOI:10.3760/cma.j.issn.1673-4416.2019.04.045. Liu T.A correlation analysis of thrombosis in primary nephrotic syndrome complicated with hyperuricemia[J].International Journal of Urology and Nephrology,2019,39(4):727-730.DOI:10.3760/cma.j.issn.1673-4416.2019.04.045.
[3] Adike A,Cherry M,Awar M.Case report:acute cerebellar thrombosis in an adult patient with IgM nephropathy[J].Methodist deBakey Cardiovascular Journal,2015,11(4):247-249.DOI:10.14797/mdcj-11-4-247.
[4] Kelddal S,Nykj?r KM,Gregersen JW,et al.Prophylactic anticoagulation in nephrotic syndrome prevents thromboembolic complications[J].BMC Nephrology,2019,20(1):139.DOI:10.1186/s12882-019-1336-8.
[5] Barbano B,Gigante A,Amoroso A,et al.Thrombosis in nephrotic syndrome[J].Seminars in Thrombosis and Hemostasis,2013,39(5):469-476.DOI:10.1055/s-0033-1343887.
[6] Labidi J,Selmi Y,Ariba YB,et al.A case of abdominal aortic thrombosis associated with the nephrotic syndrome[J].Saudi J Kidney Dis Transpl,2017,28(1):174-177.DOI:10.4103/1319-2442.198246.
[7] Wang CS,Greenbaum LA.Nephrotic Syndrome[J].Pediatric clinics of North America,2019,66(1):73-85.DOI:10.1016/j.pcl.2018.08.006.
[8] Suri D,Ahluwalia J,Saxena AK,et al.Thromboembolic complications in childhood nephrotic syndrome:a clinical profile[J].Clinical and Experimental Nephrology,2014,18(5):803-813.DOI:10.1007/s10157-013-0917-2.
[9] 马颐姣,高晓洁,贾实磊,等.儿童原发性肾病综合征并发颅内静脉血栓的临床特点及预后[J].中国小儿急救医学,2019,26(4):301-304.DOI:10.3760/cma.j.issn.1673-4912.2019.04.014. Ma YJ,Gao XJ,Jia SL,et al.Clinical features and prognosis of primary nephrotic syndrome complicated with cerebral venous sinus thrombosis in children[J].Chin Pediatr Emerg Med,2019,26(4):301-304.DOI:10.3760/cma.j.issn.1673-4912.2019.04.014.
[10] Pincus KJ,Hynicka LM.Prophylaxis of thromboembolic events in patients with nephrotic syndrome[J].Annals of Pharmacotherapy,2013,47(5):725-734.DOI:10.1345/aph.1R530.
[11] Han KH,Park JY,Min SK,et al.Bilateral iliac and popliteal arterial thrombosis in a child with focal segmental glomerulosclerosis[J].Korean Journal of Pediatrics,2016,59(5):242-245.DOI:10.3345/kjp.2016.59.5.242.
[12] 陈鹭,王辉,沈颖.儿童肾病综合征合并血栓栓塞23例回顾分析[J].中国实用儿科杂志,2012,27(6):428-431. Chen L,Wang H,Shen Y.Nephrotic syndrome complicated with thromboembolism in children:a retrospective analysis of 23 cases[J].Chinese Journal of Practical Pediatrics,2012,27(6):428-431.
[13] Tavil B,Kara F,Topaloglu R,et al.Case series of thromboembolic complications in childhood nephrotic syndrome:Hacettepe experience[J].Clinical and Experimental Nephrology,2015,19(3):506-513.DOI:10.1007/s10157-014-1005-y.
[14] Kerlin BA,Haworth K,Smoyer WE.Venous thromboembolism in pediatric nephrotic syndrome[J].Pediatric nephrology (Berlin,Germany),2014,29(6):989-997.DOI:10.1007/s00467-013-2525-5.
[15] Kerlin BA,Blatt NB,Fuh B,et al.Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome:a Midwest Pediatric Nephrology Consortium (MWPNC) study[J].J Pediatr,2009,155(1):105-110.DOI:10.1016/j.jpeds.2009.01.070.
[16] 杨剑,周美兰.原发性肾病综合征并发血栓栓塞的危险因素及预防措施[J].临床医学研究与实践,2018,3(33):9-10.DOI:10.19347/j.cnki.2096-1413.201833004. Yang J,Zhou ML.Risk factors and preventive measures for primary nephrotic syndrome complicated with thrombembolism[J].Clinical Research and Practice,2018,3(33):9-10.DOI:10.19347/j.cnki.2096-1413.201833004.
[17] 白媛,胡晓芸.新型抗凝药物防治静脉血栓栓塞症的研究进展[J].国际呼吸杂志,2016,36(15):1197-1200.DOI:10.3760/cma.j.issn.1673-436X.2016.15.017. Bai Y,Hu XY.Advances of new anticoagulant drugs in prevention and treatment of venous thromboembolism[J].Int J Respir,2016,36(15):1197-1200.DOI:10.3760/cma.j.issn.1673-436X.2016.15.017.
[18] 杨文芳,陈文腾.肾病综合征并发动脉血栓病例回顾性分析[J].齐齐哈尔医学院学报,2018,39(1):22-26.DOI:10.3969/j.issn.1002-1256.2018.01.009. Yang WF,Chen WT.Nephrotic syndrome complicated with arterial thrombosis:a retrospective study[J].Journal of Qiqihar University of Medicine,2018,39(1):22-26.DOI:10.3969/j.issn.1002-1256.2018.01.009.
[19] Mahmoodi BK,ten Kate MK,Waanders F,et al.High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome:results from a large retrospective cohort study[J].Circulation,2008,117(2):224-230.DOI:10.1161/circulationaha.107.716951.
[20] Mahmoodi BK,Brouwer JL,Veeger NJ,et al.Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age:results from a large family cohort study[J].Circulation,2008,118(16):1659-1667.DOI:10.1161/circulationaha.108.780759.
[21] Togashi H,Shimosato Y,Saida K,et al.Childhood nephrotic syndrome complicated by catastrophic multiple arterial thrombosis requiring bilateral above-knee amputation[J].Front Pediatr,2020,8:107.DOI:10.3389/fped.2020.00107.
[22] Fujinaga S,Sakuraya K.Spontaneous femoral artery thrombosis in childhood-onset nephrotic syndrome[J].Pediatr Int,2019,61(5):526-527.DOI:10.1111/ped.13842.
[23] Singhal R,Brimble KS.Thromboembolic complications in the nephrotic syndrome:pathophysiology and clinical management[J].Thrombosis Research,2006,118(3):397-407.DOI:10.1016/j.thromres.2005.03.030.
[24] Okada M,Akimoto T,Kawamata M,et al.Retroperitoneal bleeding:an experience during prophylactic anticoagulation in a patient with nephrotic syndrome[J].Clin Med Insights Case Rep,2017,10:1179547617723317.DOI:10.1177/1179547617723317.
[25] Monagle P,Chalmers E,Chan A,et al.Antithrombotic therapy in neonates and children:american college of chest physicians evidence-based clinical practice guidelines (8th Edition)[J].Chest,2008,133(6 Suppl):887s-968s.DOI:10.1378/chest.08-0762.
[26] Chuang CH,Lee CT,Cheng YF,et al.Bilateral renal infarctions and lower limbs artery thrombosis in a patient with nephrotic syndrome[J].Journal of Nephrology,2004,17(2):311-315.
[27] 董雪竹.肾病综合征合并髂动脉血栓1例[J].中国冶金工业医学杂志,2008,25(6):759-760.DOI:10.3969/j.issn.1005-5495.2008.06.128. Dong XZ.Nephrotic syndrome complicated with iliac artery thrombosis:one case report[J].Chinese Medical Journal of Metallurgical Industry,2008,25(6):759-760.DOI:10.3969/j.issn.1005-5495.2008.06.128.
[28] 佟铸,张建,谷涌泉,等.肾病综合征合并腹主动脉血栓形成及下肢动脉栓塞一例[J].中华普通外科杂志,2009,24(11):918.DOI:10.3760/cma.j.issn.1007-631X.2009.11.017. Tong Z,Zhang J,Gu YQ,et al.Nephrotic syndrome with abdominal aortic thrombosis and lower extremity arterial embolism:one case report[J].Chinese Journal of General Surgery,2009,24(11):918.DOI:10.3760/cma.j.issn.1007-631X.2009.11.017.
[29] Haddad S,Ghédira-Besbes L,Lajmi K,et al.Lower-limb arterial thrombosis in a relapse of nephrotic syndrome[J].Arch Pediatr,2010,17(9):1317-1319.DOI:10.1016/j.arcped.2010.06.008.
相似文献/References:
[1]黄金狮 陶俊峰 陈快 戴康临 陶强 彭夕华 胡华昆.经胸腔镜手术治疗先天性食管闭锁[J].临床小儿外科杂志,2011,10(03):190.
[J].Journal of Clinical Pediatric Surgery,2011,10(01):190.
[2]王贤书 崔泽 杨志国 张晓茹 岳芳 程征海 景世元. 胸腔镜辅助经胸膜外放置矫形板治疗儿童漏斗胸[J].临床小儿外科杂志,2012,11(02):123.
[3]谢川 胡吉梦 吴晔明 潘伟华 周莹.胸腔镜下膈肌折叠术治疗婴幼儿右侧 膈膨升[J].临床小儿外科杂志,2013,12(01):44.
[4]陶俊峰 黄金狮 陶强. 经胸腔镜手术治疗13例新生儿及小婴儿膈膨升[J].临床小儿外科杂志,2014,13(01):10.
[5]洪淳,俞钢,郭雪贞,等.胸腔镜手术与开胸手术治疗先天性支气管囊肿的对比分析[J].临床小儿外科杂志,2016,15(04):336.
[6]王贤书,杨志国,岳芳,等.胸腔镜下手术治疗婴幼儿胸腹裂孔疝29例[J].临床小儿外科杂志,2017,16(01):37.
[7]于洁,张娜,陈诚豪,等.胸腔镜手术治疗非新生儿期先天性膈疝77例[J].临床小儿外科杂志,2017,16(02):155.
[8]徐芳芳,任焕娣,王雯..433例3月龄以下婴儿腔镜手术的术中护理配合[HT〗[J].临床小儿外科杂志,2017,16(02):207.
[9]刘叶,王贤书,曹红宾,等.小儿脓胸的病原学特征与治疗探讨[J].临床小儿外科杂志,2017,16(05):499.
[10]钟斌,刘辉,吴金华,等.单切口胸腔镜辅助Nuss手术治疗26例儿童漏斗胸的疗效分析[J].临床小儿外科杂志,2017,16(05):506.
备注/Memo
收稿日期:2021-01-22。
基金项目:国家自然科学基金(81371449)
通讯作者:沈立,Email:shenlee2003@hotmail.com