Hu Menglong,Qi Jirong.Research advances of nutrition support in children receiving extracorporeal membrane oxygenation[J].Journal of Clinical Pediatric Surgery,2021,20(11):1076-1081.[doi:10.12260/lcxewkzz.2021.11.015]
儿童体外膜肺氧合治疗期间营养支持研究进展
- Title:
- Research advances of nutrition support in children receiving extracorporeal membrane oxygenation
- 分类号:
- R459.3;R331.372
- 摘要:
- 体外膜肺氧合（extracorporeal membrane oxygenation，ECMO）技术目前已广泛应用于危重症患者的呼吸和循环支持，但原发危重疾病、机体应激状态、ECMO支持期间特殊血流灌注方式等会造成ECMO支持下患者的能量需求不确定，并增加临床营养支持的困难。近年来，随着能量代谢检测方法和营养支持策略的不断改进，患者的临床预后得到了显著改善。本文旨在总结现阶段国内外儿童ECMO治疗期间的营养支持研究成果，为ECMO支持期间临床营养支持工作的规范化提供依据。
- Abstract:
- Extracorporeal membrane oxygenation (ECMO) is a mode of life support for children with severe cardiac or respiratory failure. Critical illness, body stress, immune reactions and hemodynamic alterations trigger immense difficulties in clinical nutritional supports. With recent improvements of energy metabolism measuring protocols and nutritional support strategies, clinical prognosis has greatly improved. This review summarized the latest researches of nutritional supports for children receiving ECMO supports and offering matching assistance.
参考文献/References:
1 Bartlett RH, Gazzaniga AB, Jefferies MR, et al. Extracorporeal membrane oxygenation (ECMO) cardiopulmonary support in infancy[J].Trans Am Soc Artif Intern Organs, 1976, 22:80-93.
2 中华医学会小儿外科学分会心胸外科学组与中华医学会肠外肠内营养学分会儿科学组.先天性心脏病患儿营养支持专家共识[J].中华小儿外科杂志, 2016, 37(1):3-8.DOI:10.3760/cma.j.issn.0253-3006.2016.01.002. Group of Cardiothoracic Surgery, Branch of Pediatric Surgery, Chinese Medical Association and Parenteral and Enteral Nutrition Division of Chinese Medical Association.Consensus of experts on nutritional support for children with congenital heart disease[J].Chin J Pediatr Surg, 2016, 37(1):3-8.DOI:10.3760/cma.j.issn.0253-3006.2016.01.002.
3 Extracorporeal Life Support Organization.ECLS registry report[DB/OL].Ann Arbor:Extracorporeal life Support Organization, 2020[2020-07-21].http://www.elso.org/Registry.aspx.
4 洪小杨, 封志纯.稳妥推进体外膜肺氧合在儿童重症医学的应用[J].中华儿科杂志, 2015, 53(8):564-565.DOI:10.3760/cma.j.issn.0578-1310.2015.08.003. Hong XY, Feng ZC.Application of steadily promoting extracorporeal membrane oxygenation in pediatric critical medicine[J].Chin J Pediatr, 2015, 53(8):564-565.DOI:10.3760/cma.j.issn.0578-1310.2015.08.003.
5 Shew SB, Keshen TH, Jahoor F, et al. The determinants of protein catabolism in neonates on extracorporeal membrane oxygenation[J].J Pediatr Surg, 1999, 34:1086-1090.DOI:10.1016/s0022-3468(99)90572-9.
6 Jaksic T, Hull MA, Modi BP, et al. A.S.P.E.N.Clinical guidelines:nutrition support of neonates supported with extracorporeal membrane oxygenation[J].J Parenter Enteral Nutr, 2010, 34(3):247-253.DOI:10.1177/0148607110369225.
7 Merus KV, Lally KP, Peek G, et al. ECMO:危重病体外心肺支持[M].3版.北京:中国环境科学出版社, 2011:419-427. Merus KV, Lally KP, Peek G, et al. ECMO:Extracorporeal cardiopulmonary support in critically ill patients[M].Version 3.Beijing:China Environmental Science Press, 2011:419-427.
8 Jaksic T, Shew SB, Keshen TH, et al. Do critically ill surgical neonates have increased energy expenditure?[J].J Pediatr Surg, 2001, 36(1):63-67.DOI:10.1053/jpsu.2001.20007.
9 Cilley RE, Wesley JR, Zwischenberger JB, et al. Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation[J].J Pediatr Surg, 1988, 23(4):306-311.DOI:10.1016/s0022-3468(88)80194-5.
10 Keshen TH, Miller RG, Jahoor F, et al. Stable isotopic quantitation of protein metabolism and energy expenditure in neonates on-and post-extracorporeal life support[J].J Pediatr Surg, 1997, 32(7):958-963.DOI:10.1016/s0022-3468(97)90377-8.
11 Kagan I, Singer P.Nutritional imbalances during extracorporeal life support[J].World Rev Nutr Diet, 2013, 105:154-159.DOI:10.1159/000341292.
12 Wollersheim T, Frank S, Muller MC, et al. Measuring Energy Expenditure in extracorporeal lung support Patients (MEEP)-Protocol, feasibility and pilot trial[J].Clin Nutr, 2018, 37(1):301-307.DOI:10.1016/j.clnu.2017.01.001.
13 Weber TR, Shah M, Stephens C, et al. Nitrogen balance in patients treated with extracorporeal membrane oxygenation[J].J Pediatr Surg, 1993, 28(7):906-908.DOI:10.1016/0022-3468(93)90693-f.
14 Desmarais TJ, Yan Y, Keller MS, et al. Enteral nutrition in neonatal and pediatric extracorporeal life support:a survey of current practice[J].J Pediatr Surg, 2015, 50(1):60-63.DOI:10.1016/j.jpedsurg.2014.10.030.
15 Ferrie S, Herkes R, Forrest P.Nutrition support during extracorporeal membrane oxygenation (ECMO) in adults:a retrospective audit of 86 patients[J].Intensive Care Med, 2013, 39(11):1989-1994.DOI:10.1007/s00134-013-3053-2.
16 Umezawa Makikado LD, Flordelís Lasierra JL, Pérez-Vela JL, et al. Nutrition support during extracorporeal membrane oxygenation (ECMO) in adults[J].Intensive Care Med, 2013, 39(12):2240.DOI:10.1007/s00134-013-3128-0.
17 Hanekamp MN, Spoel M, Sharman-Koendjbiharie I, et al. Routine enteral nutrition in neonates on extracorporeal membrane oxygenation[J].Pediatr Crit Care Med, 2005, 6(3):275-279.DOI:10.1097/01.PCC.0000161620.86647.72.
18 Piena M, Albers MJ, Van Haard PM, et al. Introduction of enteral feeding in neonates on extracorporeal membrane oxygenation after evaluation of intestinal permeability changes[J].J Pediatr Surg, 1998, 33(1):30-34.DOI:10.1016/s0022-3468(98)90355-4.
19 Jenks CL, Raman L, Dalton HJ.Pediatric extracorporeal membrane oxygenation[J].Crit Care Clin, 2017, 33(4):825-841.DOI:10.1016/j.ccc.2017.06.005.
20 Pettignano R, Heard M, Davis R, et al. Total enteral nutrition versus total parenteral nutrition during pediatric extracorporeal membrane oxygenation[J].Crit Care Med, 1998, 26(2):358-363.DOI:10.1097/00003246-199802000-00041.
21 Wertheim HF, Albers MJ, Piena-Spoel M, et al. The incidence of septic complications in newborns on extracorporeal membrane oxygenation is not affected by feeding route[J].J Pediatr Surg, 2001, 36(10):1485-1489.DOI:10.1053/jpsu.2001.27027.
22 Hanekamp MN, Spoel M, Sharman-Koendjbiharie M, et al. Gut hormone profiles in critically ill neonates on extracorporeal membrane oxygenation[J].J Pediatr Gastroenterol Nutr, 2005, 40(2):175-179.DOI:10.1097/00005176-200502000-00017.
23 Scott LK, Boudreaux K, Thaljeh F, et al. Early enteral feedings in adults receiving venovenous extracorporeal membrane oxygenation[J].J Parenter Enteral Nutr, 2004, 28(5):295-300.DOI:10.1177/0148607104028005295.
24 Hunt MF, Pierre AS, Zhou X, et al. Nutritional support in postcardiotomy shock extracorporeal membrane oxygenation patients:a prospective, observational study[J].J Surg Res, 2019, 244:257-264.DOI:10.1016/j.jss.2019.06.054.
25 Farr BJ, Rice-Townsend SE, Mehta NM.Nutrition support during pediatric extracorporeal membrane oxygenation[J].Nutr Clin Pract, 2018, 33(6):747-753.DOI:10.1002/ncp.10212.
26 Stoppe C, Nesterova E, Elke G.Nutritional support in patients with extracorporeal life support and ventricular assist devices[J].Curr Opin Crit Care, 2018, 24(4):269-276.DOI:10.1097/MCC.0000000000000512.
27 Lee HM, Archer JR, Dargan PI, et al. What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient?[J].Clin Toxicol (Phila), 2015, 53(3):145-150.DOI:10.3109/15563650.2015.1004582.
28 Scurlock C, Pinney SP, Lin HM, et al. Safety of parenteral nutrition in patients receiving a ventricular assist device[J].ASAIO J, 2014, 60(4):376-380.DOI:10.1097/MAT.0000000000000078.
29 Sin JH, Tom A, Toyoda A, et al. High-dose intravenous lipid emulsion affecting successful initiation of continuous venovenous hemofiltration and extracorporeal membrane oxygenation[J].Clin Toxicol (Phila), 2018, 56(2):149-150.DOI:10.1080/15563650.2017.1341633.
30 Kreymann KG, Berger MM, Deutz NE, et al. ESPEN Guidelines on Enteral Nutrition:Intensive care[J].Clin Nutr, 2006, 25(2):210-223.DOI:10.1016/j.clnu.2006.01.021.
31 McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ⅲ Patient:Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)[J].J Parenter Enteral Nutr, 2009, 33(3):277-316.DOI:10.1177/0148607115621863.
32 Heyland DK, Dhaliwal R, Drover JW, et al. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients[J].J Parenter Enteral Nutr, 2003, 27(5):355-373.DOI:10.1177/0148607103027005355.
33 Greathouse KC, Sakellaris KT, Tumin D, et al. Impact of early initiation of enteral nutrition on survival during pediatric extracorporeal membrane oxygenation[J].J Parenter Enteral Nutr, 2018, 42(1):205-211.DOI:10.1002/jpen.1032.
34 Armstrong LB, Ariagno K, Smallwood CD, et al. Nutrition delivery during pediatric extracorporeal membrane oxygenation therapy[J].J Parenter Enteral Nutr, 2018, 42(7):1133-1138.DOI:10.1002/jpen.1154.
35 Lukas G, Davies AR, Hilton AK, et al. Nutritional support in adult patients receiving extracorporeal membrane oxygenation[J].Crit Care Resusc, 2010, 12(4):230-234.
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备注/Memo
收稿日期:2020-08-31。
基金项目:青海省自然科学基金（编号：2021-ZJ-751）
通讯作者:戚继荣,Email:qjr7@163.com