Yang Sha,Zhai Xuan.Recent advances in the treatment of brain injury in premature infants[J].Journal of Clinical Pediatric Surgery,2021,20(09):876-880.[doi:10.12260/lcxewkzz.2021.09.015]
早产儿脑损伤的治疗进展
- Title:
- Recent advances in the treatment of brain injury in premature infants
- Keywords:
- Infant; Premature; Brain Injuries; Erythropoietin; Stem Cells
- 分类号:
- R726.511.5;R722.6
- 摘要:
- 早产儿脑损伤可继发多种严重并发症，是导致早产儿死亡及伤残的重要原因。既往早产儿脑损伤的治疗方法主要是对症治疗，近年来出现了促红细胞生成素治疗和干细胞移植治疗两种新的治疗方式，同时手术治疗也提出了"损伤控制"的新理念。本文回顾并总结了促红细胞生成素治疗和干细胞移植治疗的机制、方案及早产儿脑损伤的手术治疗新策略，为临床选择更为合理的治疗途径和方法提供参考依据。
- Abstract:
- Brain injury in early prematurity may cause a variety of severe complications, including premature mortality and disability.Previously non-specific symptomatic measures have been applied.In recent years, two new treatment options of erythropoietin dosing and stem cell transplantation have emerged.Meanwhile, a new surgical concept of "damage control" has been proposed.This review summarized the mechanisms and protocols of erythropoietin dosing, stem cell transplantation and new surgical approaches for brain injury in premature infants so as to provide rationales for clinical selection of optimal therapeutic options.
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备注/Memo
收稿日期:2020-04-05。
基金项目:重庆市科委基础科学与前沿技术研究重点项目（编号：cstc2015jcyjBX0144）
通讯作者:翟瑄,zhaixuan@163.com