Wang Junhua,Zhang Yuqi.The diagnosis and treatment of pediatric central nervous system germ cell tumors[J].Journal of Clinical Pediatric Surgery,2021,20(05):401-404.[doi:10.12260/lcxewkzz.2021.05.001]
儿童中枢神经系统生殖细胞肿瘤的诊断与治疗策略
- Title:
- The diagnosis and treatment of pediatric central nervous system germ cell tumors
- 关键词:
- 中枢神经系统肿瘤/诊断; 中枢神经系统肿瘤/外科学; 中枢神经系统肿瘤/放射疗法; 生殖细胞肿瘤/诊断; 生殖细胞肿瘤/放射疗法; 儿童
- Keywords:
- Central Nervous System Neoplasms/DI; Central Nervous System Neoplasms/SU; Central Nervous System Neoplasms/RT; Germ Cell Tumors/DI; Germ Cell Tumors/RT; Child
- 分类号:
- R739.4;R730.265.82;R726
- 摘要:
- 中枢神经系统生殖细胞肿瘤（central nervous system germ cell tumors，CNS GCTs）是儿童常见的颅内恶性肿瘤之一。目前国际上治疗儿童CNS GCTs常采用化疗、放疗、手术等综合治疗手段。CNS GCTs的临床表现、发生位置以及肿瘤成分均十分复杂，治疗方案和治疗结局多样，不同病理类型患者预后差异明显，使得CNS GCTs的处理较为复杂，因此需要通过多学科合作的综合评估与治疗以获得良好的临床结局。对患者进行全面评估、早期诊断、早期治疗，可进一步提高儿童原发性CNS GCTs的生存率，改善患者生存质量。
- Abstract:
- Central nervous system germ cell tumors (CNS GCTs) are the common intracranial malignant tumors in children.Nowadays,chemotherapy,radiotherapy,surgery and other comprehensive treatment methods are used to treat children’s CNS GCTs in the world.CNS GCTs have complex clinical manifestations,different tumor locations and tumor components,different schemes and outcomes of various treatments.The prognosis of different pathological types is significantly different,which makes the treatment of the disease more complex.Therefore,comprehensive evaluations and multidisciplinary cooperation are needed to achieve good clinical results.Comprehensive evaluation,early diagnosis and early treatment can further improve the survival rate and quality of life of children with primary CNS GCTs.
参考文献/References:
1 Wong TT,Ho DM,Chang KP,et al.Primary pediatric brain tumors:statistics of Taipei VGH,Taiwan (1975-2004)[J].Cancer,2005,104(10):2156-2167.DOI:10.1002/cncr.21430.
2 Giraud G,Ramqvist T,Pastrana DV,et al.DNA from KI,WU and Merkel cell polyomaviruses is not detected in childhood central nervous system tumours or neuroblastomas[J].PloS One,2009,4(12):e8239.DOI:10.1371/journal.pone.0008239.
3 Nakamura H,Makino K,Yano S,et al.Epidemiological study of primary intracranial tumors:a regional survey in Kumamoto prefecture in southern Japan-20-year study[J].Int J Clin Oncol,2011,16(4):314-321.DOI:10.1007/s10147-010-0178-y.
4 Packer RJ,Cohen BH,Cooney K.Intracranial germ cell tumors[J].Oncologist,2000,5(4):312-320.
5 Louis DN,Perry A,Reifenberger G,et al.The 2016 World Health Organization Classification of Tumors of the Central Nervous System:a summary[J].Acta Neuropathol,2016,131(6):803-820.DOI:10.1007/s00401-016-1545-1.
6 Matsutani M,Japanese Pediatric Brain Tumor Study Group.Combined chemotherapy and radiation therapy for CNS germ cell tumors-the Japanese experience[J].J Neurooncol,2001,54(3):311-316.DOI:10.1023/a:1012743707883.
7 Jakacki R.Central Nervous System Germ Cell Tumors[J].Curr Treat Options Neurol,2002,4(2):139-145.DOI:10.1007/s11940-002-0022-4.
8 罗世祺.颅内生殖细胞肿瘤[M].第一版,北京:科学技术文献出版社,2006. Luo SQ.Intracranial Germ Cell Tumors[M].Edition I,Beijing Science and Technology Literature Press,2006.
9 Weksberg DC,Shibamoto Y,Paulino AC.Bifocal intracranial germinoma:a retrospective analysis of treatment outcomes in 20 patients and review of the literature[J].Int J Radiat Oncol Biol Phys,2012,82(4):1341-1351.DOI:10.1016/j.ijrobp.2011.04.033.
10 Echevarria ME,Fangusaro J,Goldman S.Pediatric central nervous system germ cell tumors:a review[J].Oncologist,2008,13(6):690-699.DOI:10.1634/theoncologist.2008-0037.
11 Wu CC,Guo WY,Chang FC,et al.MRI features of pediatric intracranial germ cell tumor subtypes[J].J Neurooncol,2017,134(1):221-230.DOI:10.1007/s11060-017-2513-x.
12 Liang L,Korogi Y,Sugahara T,et al.MRI of intracranial germ-cell tumours[J].Neuroradiology,2002,44(5):382-388.DOI:10.1007/s00234-001-0752-0.
13 李强,张玉琪.颅内生殖细胞瘤的诊断与治疗[J].中华神经外科杂志,2008,24(6):479-480.DOI:10.3321/j.issn:1001-2346.2008.06.034. Li Q,Zhang YQ.Application of diagnostic chemotherapy in the diagnosis and treatment of intracranial germinoma[J].Chin J Neurosurg,2008,24(6):479-480.DOI:10.3321/j.issn:1001-2346.2008.06.034.
14 甲戈,罗世琪,邱小光,等.基底神经节区生殖细胞瘤的早期诊断及综合治疗[J].中华神经外科杂志,2009,25(5):388-390.DOI:10.3760/cma.j.issn.1001-2346.2009.05.003. Jia G,Luo SQ,Qiu XG,et al.Early diagnosis and comprehensive treatment with chemotherapy and radiotherapy for intracrinial basal ganglia germinoma:a report of 25 cases[J].Chin J Neurosurg,2009,25(5):388-390.DOI:10.3760/cma.j.issn.1001-2346.2009.05.003.
15 方陆雄,徐书翔,朱明华,等.诊断性化疗在颅内生殖细胞瘤诊治中的应用[J].中华神经外科杂志,2013,29(10):984-986.DOI:10.3760/cma.j.issn.1001-2346.2013.10.005. Fang LX,Xu SX,Zhu MH,et al.Application of diagnostic chemotherapy in the diagnosis and treatment of intracranial germinoma[J].Chin J Neurosurg,2013,29(10):984-986.DOI:10.3760/cma.j.issn.1001-2346.2013.10.005.
16 Murray MJ,Bartels U,Nishikawa R,et al.Consensus on the management of intracranial germ-cell tumours[J].Lancet Oncol,2015,16(9):e470-e477.DOI:10.1016/S1470-2045(15)00244-2.
17 Calaminus G,Frappaz D,Kortmann RD,et al.Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial[J].Neuro Oncol,2017,19(12):1661-1672.DOI:10.1093/neuonc/nox122.
18 Fangusaro J,Wu S,MacDonald S,et al.Phase Ⅱ trial of response-based radiation therapy for patients with localized CNS nongerminomatous germ cell tumors:A Children’s Oncology Group Study[J].J Clin Oncol,2019,37(34):3283-3290.DOI:10.1200/JCO.19.00701.
19 Goldman S,Bouffet E,Fisher PG,et al.Phase Ⅱ trial assessing the ability of neoadjuvant chemotherapy with or without second-look surgery to eliminate measurable disease for nongerminomatous germ cell tumors:A Children’s Oncology Group Study[J].J Clin Oncol,2015,33(22):2464-2471.DOI:10.1200/JCO.2014.59.5132.
20 Denyer S,Bhimani AD,Patil SN,et al.Treatment and survival of primary intracranial germ cell tumors:a population-based study using SEER database[J].J Cancer Res Clin Oncol,2020,146(3):671-685.DOI:10.1007/s00432-019-03088-7.
备注/Memo
收稿日期:2021-01-23。
基金项目:国家重点研发计划项目（编号：2020YFC1107602）
通讯作者:张玉琪,Email:yuqi9597@sina.com