Yu Jiabin,Lu Hongting.Research advances of circular RNAs in common pediatric malignant solid tumors[J].Journal of Clinical Pediatric Surgery,2020,19(11):1012-1015,1031.[doi:10.3969/j.issn.1671-6353.2020.11.010]
环状RNA在儿童常见恶性实体肿瘤中的研究进展
- Title:
- Research advances of circular RNAs in common pediatric malignant solid tumors
- Keywords:
- circRNA; Malignant Tumors; Solid Tumors; Differential Expression; Child
- 分类号:
- R726;R730.26
- 摘要:
- 儿童恶性肿瘤是导致儿童死亡的主要原因之一，仅次于意外死亡。环状RNA（circRNA）是一类非编码RNA分子，与传统的线性RNA不同，circRNA分子呈闭合环状结构，不易被RNA内切酶降解，表达更稳定。近年研究表明，circRNA在儿童恶性实体肿瘤的发生、转移及侵袭中发挥着重要的作用，这预示着circRNA可能成为治疗儿童恶性实体肿瘤的一个新突破口。本文就目前circRNA在儿童恶性实体肿瘤中的研究进展进行综述。
- Abstract:
- As one of the most important causes of mortality among children only after accidental death,pediatric malignant tumor has become a major factor endangering children’s health[1-2].Circular RNA (circRNA) is a class of non-coding RNA molecules.Unlike traditional linear RNA,circRNA molecules have a closed and stably expressed circular structure not liable to degradation by endonucleases.As demonstrated by recent studies,circRNA plays an important role in the occurrence,metastasis and invasion of malignant solid tumors in children.Thus it implied that circRNA may become a new therapeutic breakthrough for malignant solid tumors in children.This article reviews the latest research advances of circRNA in pediatric malignant solid tumors.
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备注/Memo
收稿日期:2019-12-14。
基金项目:青岛市民生科技计划项目（编号：18—6—17—nsh）
通讯作者:鹿洪亭,Email:luhongting@126.com