Wang Min,Zhao Sijun,Xiao Zhirong,et al.Analysis of independent risk factors for congenital microtia[J].Journal of Clinical Pediatric Surgery,2020,19(06):534-537,543.[doi:10.3969/j.issn.1671-6353.2020.06.014]
先天性小耳畸形的孕期危险因素分析
- Title:
- Analysis of independent risk factors for congenital microtia
- Keywords:
- Ear/AB; Pregnant Woman; Risk Factors
- 分类号:
- R764.7;R726.2
- 摘要:
- 目的 探讨先天性小耳畸形的孕期危险因素。方法 采用病例对照研究方法，对湖南省儿童医院2016年6月至2018年6月在门诊就诊的先天性小耳畸形患儿（病例组）及同年龄到儿童保健所就诊的正常儿童（对照组）的父母进行问卷调查，收集其社会人口学资料及围孕期生活环境、患病及用药情况、生活习惯等资料，采用卡方检验和非条件Logistic逐步回归法对各变量进行单因素及多因素分析。结果 母亲受教育程度（OR=2.440，95%CI：1.242~4.191）、孕早期感染（OR=4.933，95%CI：1.702~14.300）、孕早期用药史（OR=3.773，95%CI：1.433~9.937）、围孕期居住场所有室内装修或添置新家具（OR=4.267，95%CI：1.580~11.527）、母亲被动吸烟频率（OR=1.430，95%CI：1.115~1.835）及父母亲职业有害因素暴露（OR=2.962，95%CI：1.469~5.976）为先天性小耳畸形的独立危险因素。结论 先天性小耳畸形的发生与多种因素有关，提高围孕期自我保健的意识十分重要。
- Abstract:
- Objective To explore the independent risk factors of congenital microtia (CM) through an epidemiological survey.Methods With a case-control study design from June 2016 to June 2018,a total of 80 CM children were assigned into case group for auricular reconstruction.And another 80 children of exudative otitis media were selected as control group.Through parental interviews and questionnaire survey,social demographic profiles,peripartum living environment,diseases,drug use during pregnancy and living habits were recorded.Chi-square test and unconditional Logistic regression were employed for single and multiple factors analysis.Results Maternal education level (OR=2.440,95%CI:1.242-4.191),infection in early pregnancy (OR=4.933,95%CI:1.702-14.300),medical history in early pregnancy (OR=3.773,95%CI:1.433-9.937),indoor decoration or new furniture in peripartum living places (OR=4.267,95%CI:1.580-11.527),frequency of passive maternal smoking (OR=1.430,95%CI:1.115-1.835) and parental occupational exposure to harmful factors (OR=2.962,95%CI:1.469-5.976) were independent risk factors for congenital microtia.Conclusion The occurrence of congenital microtia is correlated with a variety of factors.And it is vital to boost the awareness of peripartum self-care.
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备注/Memo
收稿日期:2019-10-08。
基金项目:湖南省出生缺陷防治科技重大专项（编号：2019SK1010）；湖南省卫健委课题（编号：20200687）；湖南省儿童医院院级课题（编号：B24）
通讯作者:赵斯君,Emall:zhaosj3991@sohoo.com