[1]邱桐,杨开颖,陈思源,等.普萘洛尔影响婴幼儿血管瘤患儿中枢神经系统功能的新进展[J].临床小儿外科杂志,2019,18(08):646-649.[doi:10.3969/j.issn.1671-6353.2019.08.006]
　Qiu Tong,Yang Kaiying,Chen Siyuan,et al.Potential effects of propranolol on central nervous system in children with infantile hemangioma[J].Journal of Clinical Pediatric Surgery,2019,18(08):646-649.[doi:10.3969/j.issn.1671-6353.2019.08.006]
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普萘洛尔影响婴幼儿血管瘤患儿中枢神经系统功能的新进展

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第18卷 期数: 2019年08期 页码: 646-649 栏目: 专题·脉管异常类疾病 出版日期: 2019-08-25
Title:
Potential effects of propranolol on central nervous system in children with infantile hemangioma
作者:
邱桐1;  杨开颖1;  陈思源2;  吉毅1
1. 四川大学华西医院小儿外科(四川省成都市, 610041);
2. 四川大学华西医院重症医学科(四川省成都市, 610041)
Author(s):
Qiu Tong1;  Yang Kaiying1;  Chen Siyuan2;  Ji Yi1
1. Department of Pediatric Surgery;
2. Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
关键词:
婴儿; 血管瘤/治疗; 普萘洛尔; 中枢神经系统; 潜在影响
Keywords:
Infant; Hemangioma/TH; Propranolol; Central Nervous System; Potential Effect
分类号:
R543;R732.2;R741;R91
DOI:
10.3969/j.issn.1671-6353.2019.08.006
摘要:
婴幼儿血管瘤（infantile hemangioma，IH）是婴儿期最常见的良性肿瘤，目前β肾上腺素能受体阻滞剂普萘洛尔是IH的主要治疗药物，但是这种亲脂性药物能够透过血脑屏障，可能会对婴幼儿中枢神经系统功能产生潜在影响。本综述将从短期和长期记忆、精神运动功能、睡眠质量和情绪几个方面来阐述普萘洛尔对IH患儿中枢神经系统功能的潜在影响，以期为评估普萘洛尔治疗IH的安全性研究提供方向。
Abstract:
Infantile hemangioma (IH) is the most common benign tumor during infancy.Propranolol,a beta-adrenergic receptor blocker,is a major treatment for IH.However,this lipophilic drug passes through blood-brain barrier (BBB) and may have potential effects on central nervous system in infants.This review mainly describes the potential effect of propranolol on central nervous system,including short/long-term memory,psychomotor function,sleep quality and mood,in IH children and provides rationales for future safety studies of propranolol treatment.

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备注/Memo

收稿日期:2019-03-07。
基金项目:国家自然科学基金资助项目（编号：81401606）；国家自然科学基金资助项目（编号：81400862）；四川省科技厅重点研发项目（编号：2019YFS0322）；四川大学优秀青年学者基金资助项目（编号：2015SU04A15）
通讯作者:吉毅,Email:jijiyuanyuan@163.com

更新日期/Last Update: 1900-01-01