Gu Song,Gu Hongbin,Ma Jin,et al.Experimental treatment of esophageal stricture with biodegradable magnesium alloy stent.[J].Journal of Clinical Pediatric Surgery,2018,17(01):60-65.
可降解镁合金食管支架治疗食管狭窄的动物实验研究
- Title:
- Experimental treatment of esophageal stricture with biodegradable magnesium alloy stent.
- Keywords:
- Esophagus; Stents; Esophageal Stenosis; Animals; Laboratory
- 文献标志码:
- A
- 摘要:
-
目的 探讨可降解镁合金食管支架在食管狭窄治疗中的可行性。 方法 制作兔食管
狭窄动物模型。采用球囊导管扩张法将镁合金食管支架置于实验兔食管狭窄处，评估兔精神、行为和进
食变化，生理、生化和病理改变，以及食管狭窄改善情况。 结果 采用ＮａＯＨ化学烧灼法成功制作兔
食管狭窄动物模型，并在４只实验兔的食管狭窄处放置镁合金食管支架，观察期满时（支架放置后１２
周）发现有３只实验兔体内有支架放射标记残留。食管支架放置后，实验兔精神、行为未见明显异常；
兔进食情况明显改善；兔各项生理、生化指标未见明显改变；病理切片ＨＥ染色显示食管黏膜完整，黏膜
下层可见炎细胞及巨噬细胞浸润；肝肾未见明显病理性损伤改变。 结论 可降解镁合金食管支架具
有安全性高，副作用小，不良反应少等优点。经初步动物实验证实，该支架在治疗兔食管狭窄方面效果
良好，具有很大的潜在临床应用前景。
- Abstract:
- ObjectiveTo explore the feasibility of biodegradable magnesium alloy stent in the treatment of esophageal stenosis. Methods The model of esophageal stenosis was established and magnesium alloy stents were placed in esophageal stenosis in 4 rabbits by balloon catheter dilation.Their mental,behavioral,dietary,physiological and biochemical profiles were recorded.And the pathological changes of esophagus,liver and kidney and the improvement of esophageal stenosis were evaluated. Results The animal model of esophageal stenosis was successfully established by sodium hydroxide chemical cauterization.Four radiolabeled magnesium alloy stents were placed in situ and radioactive marker observed in 3/4 rabbits at Week 12 poststenting.Food intake improved significantly after stenting.No obvious changes occurred in mental,behavioral and blood biochemical parameters.Hematoxylin & eosin staining showed that the esophageal mucosa was complete,there was a submucosal infiltration of inflammatory cells and macrophages infiltrated and liver and kidney showed no obvious change. Conclusion With the advantages of high safety and minimal adverse reaction,the above stent is effective for esophageal stenosis and it has great potentials for clinical application.
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