婴幼儿室间隔缺损合并肺动脉高压的外科治疗
- 摘要:
- 目的 总结婴幼儿大型室间隔缺损(Ventricular Septal Defects ,VSD)合并肺动脉高压的外科治疗经验。方法 2008年10月至2009年5月共收治婴幼儿大型VSD 98例,男56例,女42例,年龄4 ~ 24个月,体重5.1 ~ 15.3 kg;均为单发,其中合并房间隔缺损(Atrial Septal Defect,ASD) 26例,合并三尖瓣关闭不全(Tricuspid Insufficiency, TI)18例,动脉导管未闭(Patent Ductus Arteriosus, PDA)12例。患儿均在全麻低温体外循环下实施一期矫治术。 结果 治愈95例,死亡3例,术后并发症16例,其中低心排出量综合征6例,肺不张4例,肺炎3例,心律紊乱2例,气胸1例,术后早期复查彩超,除5例有少量残余分流外,其余患儿心功能及瓣膜关闭均正常,患儿均痊愈出院。 结论 低体重、低年龄的大型室间隔缺损应尽早手术根治;术中尽量减轻体外循环损伤,保护脏器功能;术后加强呼吸道管理、预防低心排出量综合征和肺动脉高压危象是降低死亡率的关键。
参考文献/References:
1Bhatt M,Roth SJ,Kumar RK,et al.Management of infants with large,unrepaired ventricular septal defects and respiratory infectiong requiring mechanical ventilation[J].J Thorac Cardiovasc Surg,2004,127(5):1466-1473.
2 Ikawa S,Shimazaki Y,Nakano S,et al.Pulmonary vascular resistance during exercise late after repair of large ventricular septal defects relation to age at the time of repair [J].J Thorac Cardiovasc Surg,1995,109(6):1218-1224.
3朱卫华,李建华,朱雄凯,等.大型室间隔缺损合并肺动脉高压术后远期疗效的随访[J].中华儿科杂志,2001,39(10):628-629.
4 Hoffman P,Wojcik AW,Rozanski J,et al.The role of echocardiography in diagnosing double chambered right ventricle in adult s[J].Heart,2004,90(7):7892793.
5袁明远,吴朝晖,李海苗,等.国产双盘闭合伞封闭膜部室间隔缺损的近期疗效观察[J].中国现代医生,2008,46(7):47-48.
相似文献/References:
[1]柏松,李晓峰,袁峰,等.单源化手术治疗肺动脉闭锁合并室间隔缺损及重要主肺动脉侧支血管[J].临床小儿外科杂志,2010,9(06):410.
BAI Song,LI Xiao feng,YUAN Feng,et al.Unifocalization repair for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries.[J].Journal of Clinical Pediatric Surgery,2010,9(03):410.
[2]麻晓鹏,王涛,祖莹,等.肺动脉平滑肌细胞钙含量与先心病肺动脉高压的关联性研究[J].临床小儿外科杂志,2008,7(01):9.
[3]于增文 李索林 李英超 徐伟立 时保军. 腹腔镜脾切除联合胃食管周围血管离断术治疗小儿门静脉高压症[J].临床小儿外科杂志,2011,10(04):267.
[J].Journal of Clinical Pediatric Surgery,2011,10(03):267.
[4]吴鹏鹏 丁力 张峰. 6月龄以下危重婴儿室间隔缺损手术治疗的近期预后分析[J].临床小儿外科杂志,2013,12(05):358.
[5]张金山 侯文英 李龙. Warren手术治疗小儿门脉高压症50例分析[J].临床小儿外科杂志,2014,13(01):26.
[6]李青,崔传玉,范洁,等. 经胸室间隔缺损封堵术围术期氨基末端脑钠肽前体的变化研究[J].临床小儿外科杂志,2016,15(03):238.
[7]舒仕瑜,张智恩,陈功,等.先天性膈疝患儿手术后近期肺功能的临床观察[J].临床小儿外科杂志,2017,16(05):444.
[8]陈仁伟,罗金文,黄鹏,等. 外科干预在膜周部室间隔缺损介入术后房室传导阻滞的应用研究[J].临床小儿外科杂志,2018,17(12):927.
Chen Renwei,Luo Jinwen,Huang peng,et al. Effect of surgical intervention on complete atrioventricular block after interventional treatment of membranous ventricular septal defect.[J].Journal of Clinical Pediatric Surgery,2018,17(03):927.
[9]杨舟,肖云彬,王野峰,等.不同类型封堵器介入封堵膜部室间隔缺损致完全性房室传导阻滞比较研究[J].临床小儿外科杂志,2019,18(10):878.[doi:10.3969/j.issn.1671-6353.2019.10.016]
Yang Zhou,Xiao Yunbin,Wang Yefeng,et al.Follow-up of complete atrioventricular block after transcatheter closure of perimembranous ventricular septal defect with different occluding devices[J].Journal of Clinical Pediatric Surgery,2019,18(03):878.[doi:10.3969/j.issn.1671-6353.2019.10.016]
[10]张金山,李龙.小儿门静脉高压手术治疗新进展[J].临床小儿外科杂志,2019,18(12):989.[doi:10.3969/j.issn.1671-6353.2019.12.001]
Zhang Jinshan,Li Long.Recent advances in surgery for portal hypertension in children[J].Journal of Clinical Pediatric Surgery,2019,18(03):989.[doi:10.3969/j.issn.1671-6353.2019.12.001]
[11]卢圣勋,罗俊辉,邢亚闯,等.东莨菪碱改善先天性室间隔缺损合并肺动脉高压患儿体外循环术后氧合指数的效果探讨[J].临床小儿外科杂志,2017,16(05):473.
备注/Memo
作者单位:郑州市儿童医院心胸外科(河南省,450053)