同种异体幼犬睾丸组织块大网膜移植研究
- 摘要:
- 目的通过研究同种异体幼犬睾丸组织块大网膜移植,探讨同种异体睾丸组织块移植对男童原发性性腺功能低下症的治疗意义。方法以幼犬为实验对象,采用异体睾丸组织块移植的方法,将供体动物的部分睾丸组织种植到受体动物,并经皮下隧道延伸到阴囊的大网膜上。术后每周测定受体血清睾酮含量,连续测量4次,将移植组织切片分析,HE染色观察组织结构。结果睾丸组织块移植后,受体动物血清睾酮水平逐渐上升,至手术后第4周,体内激素含量较移植前明显升高(P<0.05)。病理观察移植的睾丸组织块在受体大网膜上成活,可见到间质细胞形态。结论异体睾丸组织块大网膜移植是可行的,治疗的目的仅限于提高体内雄激素水平,不涉及生育。
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