Wang Weiao,Liu Yuanmei,Zheng Zebing.Research progress on intestinal stem cells in the repair of intestinal mucosal barrier injury associated with Hirschsprung-associated enterocolitis[J].Journal of Clinical Pediatric Surgery,2026,(05):441-445.[doi:10.3760/cma.j.cn101785-202312018]
肠道干细胞参与先天性巨结肠相关性小肠结肠炎肠黏膜屏障损伤修复的研究进展
- Title:
- Research progress on intestinal stem cells in the repair of intestinal mucosal barrier injury associated with Hirschsprung-associated enterocolitis
- 关键词:
- 肠黏膜屏障; 肠道干细胞; 先天性巨结肠相关性小肠结肠炎; 外科手术; 儿童
- Keywords:
- Intestinal Mucosal Barrier; Intestinal Stem Cells; Hirschsprung-Associated Enterocolitis; Surgical Procedures; Operative; Child
- 摘要:
- 肠黏膜屏障损伤是儿童肠道疾病发生、发展的首要表现之一,目前尚缺乏促进肠黏膜屏障愈合和再生的有效方法。肠道干细胞作为肠黏膜屏障修复与再生的始祖细胞,为肠黏膜的修复再生治疗带来希望,未来有望在临床中应用。本文通过综述肠黏膜屏障在维持肠道稳态中的作用以及肠道干细胞在肠黏膜修复与再生中的作用机制,为儿童肠道炎症疾病的干预及治疗提供思路。
- Abstract:
- Injury of intestinal mucosal barrier is one of primary manifestations of intestinal diseases in children,e.g.Hirschsprung-associated enterocolitis (HAEC) and inflammatory bowel disease (IBD).Currently there is a lack of effective measures for promoting the healing and regeneration of intestinal mucosal barrier.As the progenitor cells for intestinal mucosal barrier repair and regeneration,intestinal stem cells (ISCs) have brought hopes for future applications in clinical practices.This review focused upon the role of intestinal mucosal barrier in maintaining intestinal homeostasis and summarizes the mechanisms of ISCs in intestinal mucosal repair and regeneration,providing new rationales for managing inflammatory diseases in children.
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备注/Memo
收稿日期:2023-12-7。
基金项目:国家自然科学基金(82060100);贵州省基础研究项目(黔科合基础ZK-2021-361)
通讯作者:郑泽兵,Email:zebing1988@sina.com