Zhang Jinwei,Wu Shuihua,Yuan Liping,et al.Age dependence and stratification characteristics of FOHR in children with hydrocephalus[J].Journal of Clinical Pediatric Surgery,2026,(04):360-364.[doi:10.3760/cma.j.cn101785-202510005]
儿童脑积水额角-枕角比的月龄依赖性与分层特征研究
- Title:
- Age dependence and stratification characteristics of FOHR in children with hydrocephalus
- 摘要:
- 目的 评估儿童脑积水额角-枕角比(fronto occipital horn ratio,FOHR)的月龄依赖性,将FOHR与Evans指数(Evans index,EI)并行对照,探讨不同病因、解剖生理类型及月龄分层下FOHR的分布特征,为临床量化评估提供依据。方法 本研究为回顾性对列研究。收集2017年8月至2025年8月中南大学湘雅医学院附属儿童医院(湖南省儿童医院)神经外科收治的223例脑积水患儿临床资料,按照病因(出血相关/结构性梗阻/获得性损伤/炎症)、解剖生理类型(交通性/非交通性/混合)分组;按照月龄分层,采用Spearman相关、Kruskal-Wallis检验,结合敏感性分析验证结论稳健性。结果 患儿月龄6.0(3.0,19.5)个月,FOHR 0.559(0.493,0.615)、EI 0.506(0.418,0.588);FOHR与月龄呈中等负相关(ρ=-0.337,P＜0.001),与EI高度正相关(ρ=0.762,P＜0.001);不同病因/解剖生理类型组间FOHR分布差异无统计学意义(P＞0.05),轻度、中度、重度FOHR构成比分别为28.3%、40.4%、31.4%。结论 FOHR具有显著月龄依赖性,与EI量化一致性高,适用于儿童脑积水全龄段随访;临床解读需结合月龄与症状,以EI互证,不同病因/解剖生理类型均需警惕重度脑室扩张风险。
- Abstract:
- Objective To evaluate the age dependence of frontal occipital horn ratio (FOHR) in children with hydrocephalus and compare FOHR with Evans index (EI) in parallel.The distribution characteristics of FOHR under different etiologies,anatomical and physiological types and age stratification were explored to provide rationales for clinical quantitative evaluation.Methods A retrospective analysis was conducted for the relevant clinical data of 223 children with hydrocephalus admitted into Hunan Children’s Hospital from August 2017 to August 2025.They were assigned into groups based upon the causes (hemorrhage related/structural obstruction/acquired injury/inflammation) and anatomical type (communicating/non communicating/mixed).Spearman’s correlation,Kruskal Wallis test and age stratification analysis were employed.And sensitivity analysis was utilized for verifying the robustness of the conclusions.Results The results showed that patient age was 6(3,19.5) month with a FOHR of 0.559 (0.493,0.615) and an EI of 0.506 (0.418,0.588); FOHR was correlated moderately negatively with age (ρ=-0.337,P<0.001) and highly positively with EI (ρ=0.762,P<0.001); No statistically significant difference existed in the distribution of FOHR among different etiologies/types of groups (P>0.05).And the proportions of mild,moderate and severe FOHR were 28.3%,40.4% and 31.4%,respectively.Conclusions FOHR has significant age dependence and high consistency with EI quantification,making it suitable for full age follow-ups of children with hydrocephalus; Clinical interpretation should be based upon age and symptoms,with mutual confirmation of EI.Different etiologies/types should raise a high alert for the risk of severe ventricular dilation.
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备注/Memo
收稿日期:2025-10-8。
基金项目:湖南省自然科学基金资助项目(2025JJ50682);湖南省卫生健康科研课题(20255490)
通讯作者:吴水华,Email:292454021@qq.com