Hu Zhigang,Liu Lintao,Xu Weili.Research advances on regulatory mechanism of long non-coding RNAs in the diagnosis and treatment of pediatric neuroblastoma[J].Journal of Clinical Pediatric Surgery,2025,(12):1190-1195.[doi:10.3760/cma.j.cn101785-202510009-018]
长链非编码RNA在小儿神经母细胞瘤诊治中的调控机制研究进展
- Title:
- Research advances on regulatory mechanism of long non-coding RNAs in the diagnosis and treatment of pediatric neuroblastoma
- Keywords:
- Long-noncoding RNA; Neuroblastoma; Diagnosis; Therapy; Child
- 摘要:
- 神经母细胞瘤(neuroblastoma,NB)是儿童常见的颅外实体肿瘤,其发病机制复杂,部分患儿预后不良,复发率高,因此早期诊断和有效治疗至关重要。近年研究发现,长链非编码RNA(long-noncoding RNA,lncRNA)在多种肿瘤的发生、发展中发挥重要调控作用。本文就lncRNA在NB诊断及治疗过程中的功能与分子机制研究进展进行综述,从表观遗传学角度阐明该病的发病机制,并为探索新的治疗策略提供参考。
- Abstract:
- As a common extracranial solid tumor in children,neuroblastoma (NB) has a complex pathogenesis.Some children have a poor prognosis and a high recurrence rate.Early diagnosis and effective treatment are essential.Recent studies have revealed that long non-coding RNAs (lncRNAs) play important regulatory roles in the occurrence and development of various tumors.This review summarized the latest researches on functions and molecular mechanisms of lncRNAs in the diagnosis and treatment of NB.It was intended for providing references for clarifying the pathogenesis of this disease from the perspective of epigenetics and exploring new therapeutic strategies.
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备注/Memo
收稿日期:2025-10-10。
基金项目:河北省中央引导地方科技发展资金项目(236Z7735G)
通讯作者:徐伟立,Email:27300526@hebmu.edu.cn