Wang Peixin,Zhao Jun,Wang Xingsheng,et al.Research advances the correlation between adolescent idiopathic scoliosis and paravertebral muscle imbalance[J].Journal of Clinical Pediatric Surgery,2024,(09):898-900.[doi:10.3760/cma.j.cn101785-202302028-018]
青少年特发性脊柱侧弯与椎旁肌肉失衡相关性的研究进展
- Title:
- Research advances the correlation between adolescent idiopathic scoliosis and paravertebral muscle imbalance
- 关键词:
- 青少年特发性脊柱侧弯; 肌肉发育; 张力失调; 瓢虫同源盒1; 配对盒基因3
- Keywords:
- Adolescent Idiopathic Scoliosis; Muscle Development; Dystonia; Ladybird Homeobox 1; Paired Box 3
- 摘要:
- 青少年特发性脊柱侧弯(adolescent idiopathic scoliosis,AIS)是一种三维脊柱畸形,由脊柱的侧向偏移和轴向旋转组成,是影响脊柱发育的常见全身性肌肉骨骼疾病。AIS的影响因素复杂,给儿童青少年的生活质量和身心健康带来严重影响,其中椎旁肌肉对AIS的影响受到临床医师的广泛关注。本文主要从瓢虫同源盒1(ladybird homeobox 1,LBX1)、配对盒基因3(paired box 3,PAX3)、雌激素等因素对椎旁肌肉的影响,以及肌肉体积、脂肪浸润等对AIS发生发展的影响进行综述,以期为研究脊柱侧弯发病机制和临床治疗脊柱侧弯提供一定思路。
- Abstract:
- As a three-dimensional spinal deformity consisting of lateral deviation and axial rotation of spine,adolescent idiopathic scoliosis (AIS) is the most common generalized musculoskeletal disorder affecting the development of spine.The influencing factors of AIS are rather diverse and complex.It has a serious impact on the quality-of-life and physical and mental health of children and adolescents.Especially the influence of paraspinal muscles on AIS has attracted growing attention from clinicians.This review summarized the effects of ladybird homeobox 1 (LBX1),paired box 3 (PAX3) and estrogen on paraspinal muscles,as well as the effects of muscle volume and fat infiltration on the occurrence and development of AIS.It shall provide some conceptual frameworks for elucidating the pathogenesis of scoliosis and a proper clinical treatment of scoliosis.
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备注/Memo
收稿日期:2023-2-18。
基金项目:省级重点人才项目(甘组通字【2022】77号);联合科研基金重大项目(23JRRA1529)
通讯作者:赵军,Email:673078008@qq.com